technetium-tc-99m-medronate and Retroperitoneal-Neoplasms

Topics: Aged; Bone Neoplasms; Diphosphonates; Female; Histiocytoma, Benign Fibrous; Humans; Lung Neoplasms; Male; Radionuclide Imaging; Retroperitoneal Neoplasms; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Ultrasonography

Neuroblastoma is the third most common malignancy of childhood. 131I-MIBG scintigraphy must be performed in patients with neuroblastoma at the time of staging. The aim of this study is to identify the role of 131I-MIBG scintigraphy in neuroblastoma patients in correlation with other diagnostic modalities for staging of the disease.. Twenty six patients provisionally diagnosed by clinical and imaging criteria to have neuroblastoma were included. On histopathologic verification 5 of these 26 patients were rediagnosed as non-neuroblastoma. Each patient had imaging by ultrasound, CT and/or MRI. In all cases, 131I-MIBG scintigraphy was performed, among them 15 patients had additional 99mTc-MDP bone scan.. The outcome demonstrated that CT and MRI were able to detect lesions in 19 out of 21 patients; while in 2 patients no lesions were detected. 131I-MIBG showed active lesions in 16 out of the above 19 patients, while in 3 patients 131I-MIBG was negative. There were no false positive result by 131I-MBG scan. Accordingly, 131I-MIBG is able to detect neuroblastora lesions with an overall sensitivity of 84.2%, specificity of 100% and an accuracy of 85.7%. Detection of primary lesions by 131I-MIB was significantly better than 99mTc-MDP bone scanning (92.31% vs. 61.54% respectively) (P < 0.05). For skeletal metastases, 131I-MIBG scan has a higher ability to detect more lesions than 99mTc-MDP bone scan (P = 0.023).. 131I-MIBG scintigraphy has an excellent ability to discriminate between neuroblastonia and other small round cell paediatric tumours. 131I-MIBG was found to be significantly superior to conventional bone scanning in revealing both primary and metastatic osseous lesions.

Topics: 3-Iodobenzylguanidine; Adolescent; Adrenal Gland Neoplasms; Bone Marrow Neoplasms; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Iodine Radioisotopes; Liver Neoplasms; Male; Mediastinal Neoplasms; Neoplasm Staging; Neuroblastoma; Radionuclide Imaging; Radiopharmaceuticals; Retroperitoneal Neoplasms; Spinal Neoplasms; Technetium Tc 99m Medronate

Extraosseous uptake of Tc-99m MDP has been reported in various pathologic conditions. Because of the opportunity of make an additional diagnosis, extraskeletal distribution of tracer should be inspected in every case. Malignant peripheral nerve sheath tumor (MPNST) is a rare type of neurogenic tumor. Its main clinical manifestation is a mass with or without pain. MPNST can be seen in all 4 extremities, the trunk, head and neck regions, but most commonly occur in the thigh, buttocks, and supraclavicular regions. Presented here is a rare case of MPNST in which Tc-99m MDP uptake by the primary lesion and metastases were clearly demonstrated on bone scintigraphy.

Topics: Humans; Lung Neoplasms; Male; Middle Aged; Muscle Neoplasms; Muscle, Skeletal; Nerve Sheath Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Retroperitoneal Neoplasms; Technetium Tc 99m Medronate

Extraskeletal osteosarcoma (ExOs) is a rare, usually highly aggressive malignancy, which affects individuals beyond the fifth decade of life. ExOs prinicipally occurs as a soft tissue mass in a limb or retroperitoneum. We present the case of a 58-year-old man with a huge abdominal mass who underwent a complete range of clinical imaging investigations including computed tomography (CT), skeletal scintigraphy (BS) and positron emission tomography (PET). These exams showed a central calcified and ossified, strongly metabolic retroperitoneal tumour suggestive of an ExOs. This diagnosis was later confirmed by histopathology. To our knowledge, such a case has not previously been documented fully using radiological imaging correlated to modern nuclear medicine techniques such as PET.

Topics: Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Osteosarcoma; Positron-Emission Tomography; Radiopharmaceuticals; Retroperitoneal Neoplasms; Technetium Tc 99m Medronate

Topics: Bone and Bones; Humans; Liposarcoma; Male; Middle Aged; Radionuclide Imaging; Retroperitoneal Neoplasms; Technetium Tc 99m Medronate

Various causes for cold defects on bone scans (e.g., avascular necrosis) have been described. A case is presented in which a cold defect on a technetium-99m-methylene diphosphonate bone scan was the result of malignant fibrous histiocytoma.

Topics: Aged; Histiocytoma, Benign Fibrous; Humans; Male; Radionuclide Imaging; Retroperitoneal Neoplasms; Soft Tissue Neoplasms; Spinal Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Bone Neoplasms; Child, Preschool; Diagnostic Errors; False Positive Reactions; Ganglioneuroma; Humans; Radionuclide Imaging; Retroperitoneal Neoplasms; Sympathectomy; Technetium Tc 99m Medronate

Topics: Adult; Diagnosis, Differential; Dysgerminoma; Humans; Kidney; Kidney Neoplasms; Male; Radionuclide Imaging; Retroperitoneal Neoplasms; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Teratoma; Testicular Neoplasms

Two cases of primary retroperitoneal benign teratoma, in which Tc-99m MDP localized in the primary tumor are presented. Localization of bone-imaging agents in neuroblastoma has been reported but, extraosseous localization of bone-imaging agents in teratomas has not been confirmed.

Topics: Child, Preschool; Dermoid Cyst; Female; Humans; Male; Radionuclide Imaging; Retroperitoneal Neoplasms; Technetium Tc 99m Medronate

Endometriosis is a common disorder, affecting women in the child-bearing years. While urologic involvement is rare, the bladder is more often affected than the ureter. The authors describe the case of a 30-year-old woman who had unilateral ureteral obstruction secondary to an isolated periureteral retroperitoneal area of endometriosis. The theories of histogenesis are discussed. Current treatment consists of surgery or hormonal manipulation or a combination of the two.

Topics: Adult; Diphosphonates; Endometriosis; Female; Humans; Hydronephrosis; Radionuclide Imaging; Retroperitoneal Neoplasms; Technetium; Technetium Tc 99m Medronate; Ultrasonography; Ureteral Obstruction

Topics: Adult; Chondrosarcoma; Female; Humans; Radionuclide Imaging; Retroperitoneal Neoplasms; Technetium Tc 99m Medronate

A total of 2530 consecutive bone scans were examined to evaluate the number and the type of soft tissue neoplasms detected with bone-seeking phosphonates. Sixty-eight primary or secondary soft tissue neoplasms of 63 patients accumulated 99mTc -methylene diphosphonate and 2 accumulated 99mTc -diphosphonate, and one metastasis was seen as a nonactive 'cold' focus in the urinary bladder. The localization of tumors was: 19 in the lung, 15 in the liver, 11 in the kidney, 10 in the peritoneal cavity or ascites, 5 in the large bowel, 4 in the vascular or lymphatic system, 3 in the connective tissue or muscles, 2 in the ovary, 1 in the urinary bladder, and 1 in the brain. Our results differ in many respects from those reported in the literature. The causes of the differences are discussed.

Topics: Abdominal Neoplasms; Adenocarcinoma; Adolescent; Adult; Aged; Bone and Bones; Carcinoma, Small Cell; Colonic Neoplasms; Diphosphonates; Female; Humans; Liver Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Retroperitoneal Neoplasms; Soft Tissue Neoplasms; Technetium; Technetium Compounds; Technetium Tc 99m Medronate

Topics: Adult; Diphosphonates; Humans; Kidney; Male; Neurofibroma; Radiation Injuries; Radiography; Radionuclide Imaging; Retroperitoneal Neoplasms; Technetium; Technetium Tc 99m Medronate