technetium-tc-99m-medronate and Protein-Losing-Enteropathies

We present a case of a 60-year-old man with a history of severe hypoproteinemia and constitutional syndrome, suspected to have protein-losing enteropathy (PLE). Bone scintigraphy ((99m)Tc-MDP) performed to rule out the presence of bone metastases incidentally showed abnormal uptake in abdominal soft tissue. The patient unexpectedly died of heart failure, and autopsy revealed microscopic alterations consistent with PLE exclusively in the right colon, corresponding to the area of abnormal uptake. Few similar cases have been published, but none of them reported correlative pathological findings affecting the area of abnormal tracer uptake. In this case of PLE, (99m)Tc-MDP scintigraphy was a useful imaging method for localizing the site of protein loss, showing a focal area of alteration in the right colon. This finding could also have been of great help in case that surgery had been finally performed to control the protein loss.

Topics: Autopsy; Biological Transport; Bone and Bones; Humans; Intestinal Mucosa; Intestines; Male; Middle Aged; Protein-Losing Enteropathies; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Child; Female; Humans; Protein-Losing Enteropathies; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

This case report describes the incidental finding of intestinal leakage during bone scan imaging with Tc-99m methylene diphosphonate (MDP) in a patient with previously diagnosed protein-losing enteropathy (PLE). Most radiopharmaceuticals reported in the literature that are useful for making this diagnosis are not generally available for clinical use in the United States. This report suggests that Tc-99m-MDP is useful for confirming the diagnosis of PLE although further investigations are indicated to determine the accuracy of this method.

Topics: Child; Female; Humans; Protein-Losing Enteropathies; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Adult; Female; Humans; Intestinal Mucosa; Intestines; Protein-Losing Enteropathies; Radionuclide Imaging; Technetium Tc 99m Medronate

The authors describe a patient with protein-losing enteropathy in whom abnormal intestinal accumulation of tracer occurred during Tc-99m human serum albumin scintigraphy. Abnormal leakage of the radiotracer was observed in the left upper abdomen and was confirmed by Tc-99m MDP scintigraphy. Both Tc-99m HSA scintigraphy and Tc-99m MDP scintigraphy are useful in the detection of protein-losing enteropathy.

Topics: Adult; Humans; Male; Protein-Losing Enteropathies; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Aggregated Albumin; Technetium Tc 99m Medronate; Whole-Body Counting

Topics: Adolescent; Bone and Bones; Colon; Female; Humans; Protein-Losing Enteropathies; Radionuclide Imaging; Technetium Tc 99m Medronate