technetium-tc-99m-medronate and Paralysis

Post-poliomyelitis syndrome causes variable musculoskeletal manifestations including pain, muscle weakness and fatigue. These manifestations are commonly secondary to overuse and misuse of muscles and joints and could follow a fall. Bone scan can be useful in determining the underlying cause and follow-up. The objective of this study was to describe the late scintigraphic patterns on bone scan following poliomyelitis.. Bone scans of 8 adult patients (7 female and 1 male), aged 35 to 53 years, who were known to have paralytic poliomyelitis, were retrospectively studied. Six patients had unilateral while 1 had bilateral disease. All patients had three-phase bone scan and 5 had SPECT study as well. Studies were reviewed by two qualified nuclear medicine physicians and findings were recorded and analyzed.. Several patterns were consistently identified: decreased blood pool activity in the affected lower limb of all patients; deformed ipsilateral hemi-pelvis with reduced uptake on the affected side in all patients with unilateral disease; stress changes with increased uptake in the bones of the contra-lateral lower extremity; and degenerative changes in multiple joints (shoulder, knee, hip, ankle and spine). Significant scoliosis was only noted in the patient with bilateral disease.. Scintigraphic patterns on bone scan associated with the post-poliomyelitis syndrome and persistent weakness following a distant episode of poliomyelitis have been described. Awareness of these characteristic scintigraphic findings may facilitate an accurate diagnosis and lead to more appropriate patient management.

Topics: Adult; Bone and Bones; Female; Humans; Male; Middle Aged; Paralysis; Postpoliomyelitis Syndrome; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

A case of atypical osseous tuberculosis (TB) mimicking multiple secondary metastases on radiologic and nuclear imaging is presented.. To emphasize the contribution of nuclear bone scanning for the assessment of osseous tuberculosis in typical and atypical presentations.. Skeletal locations of TB mostly involve the dorsolumbar spine and diagnosis is often delayed. The presence of multiple TB sites can mimic secondary metastases and biopsy remains the mainstay for final diagnosis.. Clinical symptoms, lab tests, and imaging data are presented. Possible diagnoses are discussed. A review of imaging characteristics in cases of typical and atypical presentations of osseous TB is proposed.. A dorsal spine spondylitis was first diagnosed on a 56-year-old patient presenting neurologic deficit of the left arm. Fine needle aspiration identified bacterial infection but was negative for Mycobacterium tuberculosis. Whole-body bone scan allowed the identification of an asymptomatic sacroiliac lesion, which was accessible to biopsy and gave a final diagnosis.. Nuclear bone scanning should be kept in mind when assessing spinal pain in patients at high risk of TB infection or reactivation.

Topics: Africa, Northern; Arm; Back Pain; Biopsy, Fine-Needle; Diabetes Complications; Diagnosis, Differential; Epidural Abscess; False Negative Reactions; Humans; Lumbar Vertebrae; Male; Middle Aged; Mycobacterium tuberculosis; Osteolysis; Paralysis; Radionuclide Imaging; Radiopharmaceuticals; Recurrence; Sacroiliac Joint; Sacrum; Spinal Neoplasms; Spondylitis; Technetium Tc 99m Medronate; Thoracic Vertebrae; Tuberculoma; Tuberculosis, Osteoarticular

Topics: Aged; Humans; Male; Muscle Spasticity; Osteitis Deformans; Paralysis; Radionuclide Imaging; Technetium Tc 99m Medronate

A large family with a history of hereditary chemodectoma has been successfully screened by means of radionuclide scintiangiography. This procedure could restrict selective and more invasive roentgenangiography only to those cases in which flow patterns are abnormal. Three asymptomatic cases of chemodectoma were revealed by this method. Early therapeutic measures may now be feasible. We discuss the possibilities for surveillance of these families without causing discomfort to the group involved.

Topics: Adolescent; Adult; Aged; Carotid Arteries; Diphosphonates; Female; Head and Neck Neoplasms; Humans; Male; Methods; Middle Aged; Paraganglioma, Extra-Adrenal; Paralysis; Pedigree; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate