technetium-tc-99m-medronate and Ovarian-Neoplasms

Technetium-99m methylene diphosphonate (Tc-99m MDP) bone scans have long been used by clinicians to diagnose osseous metastases in patients with cancer. However, in several benign and malignant diseases, notably those characterized by extensive soft tissue calcification, Tc-99m MDP may be taken up by the tumor itself. We present a case of a stage IIIC psammoma-rich low-grade serous carcinoma of the ovary, whose identity and extent of disease were first suggested by Tc-99m MDP scintigraphy. The literature concerning this form of cancer, and the use of Tc-99m MDP bone scans to image soft tissue lesions, are reviewed.

Topics: Cystadenocarcinoma, Serous; Female; Humans; Middle Aged; Ovarian Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Soft Tissue Neoplasms; Technetium Tc 99m Medronate

Ovarian thecoma is a benign and rare neoplasm that accounts for 0.5% to 1% of all ovarian tumors. A 55-year-old woman with known breast cancer underwent a metastatic workup before surgery. The Tc-MDP whole-body bone scan revealed intense uptake in the left pelvic region. Hybrid SPECT/CT imaging showed that the elevated Tc-MDP activity was in a tumor with calcification in the left adnexa. Dynamic enhanced MRI revealed marked enhancement of the tumor. Resection of the tumor was subsequently performed, and pathologic analysis confirmed the diagnosis of an ovarian thecoma.

Topics: Breast Neoplasms; Female; Humans; Incidental Findings; Middle Aged; Ovarian Neoplasms; Single Photon Emission Computed Tomography Computed Tomography; Technetium Tc 99m Medronate; Thecoma; Whole Body Imaging

Cutaneous involvement is generally unusual for metastases in a variety of primary malignancies including patients diagnosed with ovarian cancer. We report the rare observance of subcutaneous lesions from an aggressive ovarian primary carcinoma with unusual uptake of 99mTc-MDP on a tomographic whole-body bone scan without osseous metastatic lesions or uptake. The findings were correlated with cross-sectional imaging in addition to histological analysis.

Topics: Female; Humans; Ovarian Neoplasms; Radionuclide Imaging; Subcutaneous Tissue; Technetium Tc 99m Medronate

Breast metastasis from a primary ovarian neoplasm is very rare. We report a case of breast metastasis along with involvement of the liver, spleen, and pelvis from ovarian carcinoma in a 54-year-old woman demonstrated by whole-body bone scanning. Ovarian metastatic deposits frequently show calcification, and a Tc-99m MDP bone scan could be useful in determining the extent of calcified soft tissue metastatic spread in these patients. A review of the literature of breast metastases form ovarian carcinoma is discussed.

Topics: Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Carcinoma, Papillary; Female; Humans; Incidental Findings; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Whole-Body Counting

Topics: Bone Neoplasms; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Middle Aged; Ovarian Neoplasms; Pelvic Bones; Pelvic Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Abdominal Neoplasms; Bone Neoplasms; Calcinosis; Child; Diagnosis, Differential; Female; Humans; Ovarian Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Teratoma

Topics: Bone and Bones; Calcinosis; Cystadenocarcinoma; Female; Humans; Ovarian Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Umbilicus

Topics: Aged; Arthralgia; Cystadenoma; Female; Hip Joint; Humans; Ovarian Neoplasms; Pelvis; Radionuclide Imaging; Radiopharmaceuticals; Regional Blood Flow; Technetium Tc 99m Medronate; Ultrasonography

Topics: Adenocarcinoma, Papillary; Calcinosis; Female; Humans; Middle Aged; Ovarian Neoplasms; Peritoneal Neoplasms; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Topics: Adult; Dysgerminoma; Female; Hemangioma; Humans; Neoplasms, Multiple Primary; Ovarian Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Skull; Skull Neoplasms; Technetium Tc 99m Medronate

Topics: Adult; Calcinosis; Cystadenocarcinoma, Papillary; Female; Humans; Lymphatic Metastasis; Mediastinal Neoplasms; Ovarian Neoplasms; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Aged; Bone and Bones; Bone Neoplasms; Colon; Cystadenocarcinoma, Papillary; Female; Humans; Ovarian Neoplasms; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

A method of superimposing computed tomography (CT) and immunoscintigraphic (IS) single photon emission tomography (SPET) slices is presented and has been applied to 10 patients with suspected cancer recurrence. IS was performed with carcinoembryonic antigen (CEA)-specific indium-111 monoclonal antibodies (MoAbs) in 5 patients with colorectal cancer, and with OC125 111In-MoAbs in 5 patients with ovarian cancer. All patients had an abnormal CT image result in the pelvis, which was interpreted 5 times as recurrence, once as doubtful and four times as scar fibrosis. Recurrence was subsequently proven in all patients. Bone scintigraphy (BS) SPET was recorded at the same time as IS. No special technique was used during BS, IS or CT acquisition. CT images were fed into a computer using a CCD camera. Using the internal anatomical landmarks provided by the pelvic bone structures seen on CT and BS, an operator had to select corresponding fiducial points, which were used by the software to register the images. The final results were CT-BS and CT-IS superimposed images. CT-BS images were used for quality control. In all patients, the inspection of CT-BS and CT-IS showed that the registration process is accurate and assists in the co-interpretation of CT and IS images.

Topics: Colorectal Neoplasms; Female; Humans; Indium Radioisotopes; Neoplasm Recurrence, Local; Ovarian Neoplasms; Radioimmunodetection; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Combining the volume rendering and bicolour visualization techniques is proposed as an aid in interpreting single photon emission tomography (SPET) immunoscintigraphy (IS) recorded simultaneously with SPET bone landmarking (BL). The combination helps in localizing abnormal monoclonal uptake and in differentiating it from a physiological radioactivity distribution. The so-called rendered images (RIs) are obtained in both IS and BL studies according to a depth- weighted maximum activity projection algorithm. Fused BL and IS RIs are constructed by a simple, pixel by pixel addition. They are displayed using a bicolour grey-red scale, which makes it possible to visualize both studies by a transparency effect. This method was applied to patients suspected of suffering colorectal or ovarian cancer recurrences, in whom monoclonal antibodies against carcinoembryonic antigen, B72-3 or OC125 labelled with indium-111 were used.

Topics: Bone and Bones; Colorectal Neoplasms; Female; Humans; Indium Radioisotopes; Neoplasm Recurrence, Local; Ovarian Neoplasms; Radioimmunodetection; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

A patient with ovarian carcinoma was evaluated for skeletal metastasis with a routine whole body bone scan. Although no bone metastases were visualized, there was dramatic accumulation of tracer in the soft tissues of the abdomen. CT revealed calcifying soft tissue metastases on the liver surface, the bowel serosa, and in the pelvis corresponding to the abnormal areas of Tc-99m MDP uptake. Tumor necrosis and ongoing calcification within the metastatic sites are possible explanations for this unusual soft tissue concentration of the bone-seeking radiopharmaceutical. In patients with metastatic ovarian carcinoma, careful review of extraosseous regions on bone scan images may provide valuable diagnostic information.

Topics: Abdominal Neoplasms; Adult; Bone Neoplasms; Carcinoma, Papillary; Female; Humans; Ovarian Neoplasms; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium Tc 99m Medronate

An ovarian mucinous cystadenocarcinoma which moderately accumulated Tc-99m MDP was imaged during a whole body bone scan. The primary tumor and its implants in the peritoneal cavity were both visualized and correlated with US and TCT scan findings. As a result, the radiopharmaceutical distribution accurately delineated the primary tumor and the region of tumor involvement within the peritoneal cavity. Therefore, a whole body bone scan offers a potential method for assessing neoplastic size and spread.

Topics: Aged; Aged, 80 and over; Cystadenocarcinoma; Female; Humans; Ovarian Neoplasms; Pseudomyxoma Peritonei; Radionuclide Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Ultrasonography

Examination for liver and bone metastases was performed in 30 women suffering from carcinoma of the uterus and in 27 with cervical and 37 with ovarian carcinoma. Scintigraphy was the examination method of choice in bone metastases and computed tomography in liver metastases. Bone metastases were not seen in any patient in the stages I to IV with carcinoma of the cervix and ovarian carcinoma. Bone metastases were found in one patient in stage III and in one in stage IV with carcinoma of the uterus. Liver metastases were found in four patients in stages III and IV with carcinoma of the uterus and in five patients with ovarian carcinoma.

Topics: Bone Neoplasms; Female; Humans; Liver Neoplasms; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Uterine Cervical Neoplasms; Uterine Neoplasms

In a 45-year old patient with serous cystadenocarcinoma of the ovary CT showed small calcifications in metastases along peritoneal surfaces. These "psammoma bodies" indicated abdominal implants, which in other respects would not have been demonstrable via CT scans because of their small size. During bone scintigraphy the calcifications caused unusual extraskeletal focal uptake of 99mTc-MDP in the abdomen.

Topics: Bone Neoplasms; Calcinosis; Cystadenocarcinoma; Female; Humans; Middle Aged; Ovarian Neoplasms; Peritoneal Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Two cases of extra-osseous uptake of 99mTc-methylene diphosphonate (MDP) by non-osseous metastatic tumors are reported. One was a metastasis with ossification in the abdominal wall from carcinoma of the sigmoid colon and the other was a metastasis with calcification from an ovarian carcinoma. The mechanism of extra-osseous uptake of 99mTc-MDP is discussed. Bone scintigraphy can be a potential means to assess tumor spread with ossifications and calcifications.

Topics: Abdominal Neoplasms; Adenocarcinoma, Mucinous; Adult; Bone Neoplasms; Calcinosis; Cystadenocarcinoma; Female; Humans; Male; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Sigmoid Neoplasms; Technetium Tc 99m Medronate

An unusual case of ovarian carcinoma is presented with extra-abdominal soft tissue metastasis. These demonstrate calcification on plain films and CT, as well as avid uptake of Tc-99m MDP.

Topics: Adult; Cystadenocarcinoma; Diphosphonates; Female; Humans; Ovarian Neoplasms; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Many disease states, including neoplasia, have been detected by bone scanning. Among the neoplastic processes detected by bone imaging agents are ovarian tumors, both benign and malignant. This report is concerned with the visualization of a benign Brenner tumor during routine Tc-99m MDP bone scanning.

Topics: Brenner Tumor; Diphosphonates; Female; Humans; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

A total of 2530 consecutive bone scans were examined to evaluate the number and the type of soft tissue neoplasms detected with bone-seeking phosphonates. Sixty-eight primary or secondary soft tissue neoplasms of 63 patients accumulated 99mTc -methylene diphosphonate and 2 accumulated 99mTc -diphosphonate, and one metastasis was seen as a nonactive 'cold' focus in the urinary bladder. The localization of tumors was: 19 in the lung, 15 in the liver, 11 in the kidney, 10 in the peritoneal cavity or ascites, 5 in the large bowel, 4 in the vascular or lymphatic system, 3 in the connective tissue or muscles, 2 in the ovary, 1 in the urinary bladder, and 1 in the brain. Our results differ in many respects from those reported in the literature. The causes of the differences are discussed.

Topics: Abdominal Neoplasms; Adenocarcinoma; Adolescent; Adult; Aged; Bone and Bones; Carcinoma, Small Cell; Colonic Neoplasms; Diphosphonates; Female; Humans; Liver Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Retroperitoneal Neoplasms; Soft Tissue Neoplasms; Technetium; Technetium Compounds; Technetium Tc 99m Medronate

Topics: Diagnostic Errors; Diphosphonates; Female; Humans; Ovarian Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Teratoma; Urinary Bladder

Topics: Abdomen; Adenocarcinoma; Adult; Aged; Ascitic Fluid; Diphosphonates; Female; Humans; Leukemia, Myeloid; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Stomach Neoplasms; Technetium; Technetium Tc 99m Medronate; Teratoma; Testicular Neoplasms; Urethral Neoplasms

Topics: Bone and Bones; Dermoid Cyst; Diphosphonates; Female; Humans; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate