technetium-tc-99m-medronate and Osteopetrosis

Osteopetrosis, also known as marble bone disease, is a clinically rare genetic disease, which represents a heterogeneous group of rare, inherited bone dysplasias that share the hallmark of abnormally increased bone density caused by osteoclast dysfunction. Hereby, the authors describe a case of osteopetrosis that showed increased diffuse radioactive uptake on whole body bone (99)Tc(m)-methylene diphosphonate imaging in a 56-year-old man, which increased universal radioactive uptake on craniofacial bone imaging, and enlargement of the limb long bone near the joints with evenly symmetrical enriched distribution of radioactivity. Osteopetrosis was made which based on these features and characteristics shown on (99)Tc(m)-MDP imaging.Skeletal scintigraphy with Tc-methylene diphosphonate imaging is helpful to the diagnosis of osteopetrosis. There is a characteristic of osteopetrosis different from other bone metabolic diseases.

Topics: Humans; Male; Middle Aged; Osteopetrosis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Adult; Bone and Bones; Bone Marrow; Humans; Male; Osteopetrosis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Technetium Tc 99m Sulfur Colloid

Topics: Bone and Bones; Female; Genes, Dominant; Humans; Middle Aged; Osteopetrosis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Skeletal, reticuloendothelial and renal images were obtained on a patient with osteopetrosis using Tc-99m MDP, Tc-99m HSA millimicrospheres and Tc-99m DTPA respectively. The bone scan showed increased uptake in multiple fracture sites, in the frontal bone, and in the splayed metaphyses of long bones while the remainder of the skeleton appeared normal. Reticuloendothelial images demonstrated an absence of bone marrow activity, hepatosplenomegaly and a site of extramedullary hematopoiesis. A renogram demonstrated a left kidney displaced and distorted by the massive splenomegaly.

Topics: Adult; Fractures, Bone; Humans; Kidney Diseases; Male; Mononuclear Phagocyte System; Organometallic Compounds; Osteopetrosis; Pentetic Acid; Radionuclide Imaging; Technetium; Technetium Tc 99m Aggregated Albumin; Technetium Tc 99m Medronate; Technetium Tc 99m Pentetate

Topics: Adult; Bone and Bones; Diphosphonates; Female; Humans; Knee Joint; Osteopetrosis; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate