technetium-tc-99m-medronate and Orbital-Neoplasms

A 27-year-old woman, who has received a hydroxyapatite orbital implant in the right eye due to a trauma 6 years ago, was newly diagnosis with left breast invasive ductal carcinoma. Tc-MDP bone scan showed an increased radiotracer accumulation in the right orbit and SPECT/CT confirmed the focal accumulation at the site of the implant, without any sign of local malignant lesions or orbital infection. Radionuclide imaging could provide certain useful information in diagnosing or differential diagnosing orbital disease.

Topics: Adult; Breast Neoplasms; Carcinoma, Ductal; Diagnosis, Differential; Female; Humans; Orbital Implants; Orbital Neoplasms; Radiopharmaceuticals; Single Photon Emission Computed Tomography Computed Tomography; Technetium Tc 99m Medronate

Topics: Adolescent; Bone Neoplasms; Humans; Magnetic Resonance Imaging; Male; Orbital Neoplasms; Osteoma, Osteoid; Radionuclide Imaging; Technetium Tc 99m Medronate

A case is presented of metastatic tumor causing Jacod's syndrome: total ophthalmoplegia, blindness, and trigeminal neuralgia. Abnormal soft tissue invading the orbital apex, anterior clinoid process, and cavernous sinus was difficult to assess by CT and MRI, but dual-isotope SPECT including Tc-99m HMDP bone imaging and Tl-201 tumor imaging strongly suggested that the cause of this rare syndrome was a small metastatic tumor. Although the therapeutic effect was also difficult to assess by anatomic imaging alone, dual-isotope SPECT after radiation therapy showed a decline of tumor viability.

Topics: Aged; Blindness; Carcinoma, Non-Small-Cell Lung; Cavernous Sinus; Follow-Up Studies; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Male; Ophthalmoplegia; Orbital Neoplasms; Radiopharmaceuticals; Skull Base Neoplasms; Sphenoid Bone; Syndrome; Technetium Tc 99m Medronate; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Trigeminal Neuralgia

Reconstruction of calvarium after tumor resection may present several technical difficulties. The authors reused the resected calvarial bone in four patients after submitting the bone to a lethal dose of gamma radiation. The authors conclude that resected, irradiated, tumorous bone can be reused for the reconstruction of its own defect. This provides a simple method of reconstruction. Partial bone resorption should be anticipated but further reconstruction, if needed, will be facilitated.

Topics: Adult; Bone Transplantation; Cranial Irradiation; Female; Frontal Sinus; Gamma Rays; Humans; Male; Meningioma; Middle Aged; Orbital Neoplasms; Paranasal Sinus Neoplasms; Radionuclide Imaging; Replantation; Skull; Skull Neoplasms; Sphenoid Bone; Sterilization; Technetium Tc 99m Medronate; Temporal Bone

Topics: Aged; Bone Neoplasms; Disease Progression; Humans; Male; Orbit; Orbital Neoplasms; Prostatic Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Whole-Body Counting

Topics: Adenocarcinoma; Female; Humans; Middle Aged; Orbital Neoplasms; Radionuclide Imaging; Skin Neoplasms; Technetium Tc 99m Medronate

A new radiopharmaceutical, I-131 metaiodobenzylguanidine (I-131 MIBG) was used to determine the location and to follow-up tumors in a 13-month-old girl with neuroblastoma. I-131 MIBG imaging revealed both a primary abdominal tumor and a distant metastatic orbital tumor. Follow-up study with I-131 MIBG imaging demonstrated significant resolution of tumors after external radiotherapy and chemotherapy. I-131 MIBG imaging is a simple, safe, and specific method of determining the location of tumors and also is clinically useful in the evaluation and management of patients with neuroblastoma.

Topics: 3-Iodobenzylguanidine; Abdominal Neoplasms; Female; Follow-Up Studies; Humans; Infant; Iodine Radioisotopes; Iodobenzenes; Neuroblastoma; Orbital Neoplasms; Radionuclide Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed