technetium-tc-99m-medronate and Nephritis

A 34-year-old woman with pancreatic acinar cell carcinoma underwent a Tc-MDP bone scan to rule out potential bone metastasis because of back pain 18 months after radiation therapy. The bone scintigraphy revealed increased uptake over the upper pole of both kidneys corresponding to the portions of the kidneys included within the radiation field, consisting with radiation nephritis.

Topics: Adult; Bone Neoplasms; Carcinoma, Acinar Cell; Diagnosis, Differential; Female; Humans; Nephritis; Pancreatic Neoplasms; Radiation Injuries; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

The authors present a comparison of the findings for thallium-201 (Tl-201), Tc-99m MAG3 and Tc-99m MDP in subacute and chronic radiation nephritis in a 9-yr-old boy who was treated by radiation therapy for alveolar rhabdomyosarcoma of the left chest wall by a radiation port that partially included the left kidney. Tl-201 imaging three and six months later showed a cortical defect in the left kidney due to radiation nephritis. Tc-99m MDP scan showed increased uptake on both occasions, but more marked in the subacute period than in the chronic period. Tc-99m MAG3 showed decreased concentration and increased cortical retention three months later. Six months after the radiation therapy, a cortical defect corresponding to the cortical area that showed increased parenchymal retention was more prominent in the Tc-99m MAG3 scan. In the present case, Tc-99m MDP, Tl-201 and Tc-99m MAG3 findings may provide useful information for understanding pathophysiological damage in the kidney after radiation.

Topics: Child; Chronic Disease; Humans; Kidney; Male; Nephritis; Radiation Injuries; Radionuclide Imaging; Radiopharmaceuticals; Rhabdomyosarcoma, Alveolar; Ribs; Technetium Tc 99m Medronate; Technetium Tc 99m Mertiatide; Thallium Radioisotopes

Topics: Adrenal Glands; Adult; Breast Neoplasms; Female; Humans; Nephritis; Radiation Injuries; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Adult; Amphotericin B; Anemia, Sickle Cell; Bone and Bones; Diphosphonates; Female; Humans; Hypercalcemia; Kidney; Lupus Erythematosus, Systemic; Male; Middle Aged; Nephritis; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate