technetium-tc-99m-medronate and Muscular-Diseases

A 62-year-old man presented with a 5-year history of progressive myasthenia, myalgia, and skin changes. Upon laboratory testing, elevated serum creatine kinase and lactate dehydrogenase, as well as monoclonal immunoglobulin Gκ, were observed. A bone scan revealed generalized muscular uptake of 99m Tc-MDP, whereas 18 F-FDG PET/CT demonstrated only mild hypermetabolism of the muscles. A muscle biopsy showed myofibrillary vacuolar degeneration, and a skin biopsy indicated scleromyxedema. Based on these findings, the patient was diagnosed with scleromyxedema-associated myopathy.

Topics: Bone Neoplasms; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Muscular Diseases; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Scleromyxedema; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

A 37-year-old woman was admitted to our department with general fatigue, fever, and asymmetric pain in her lower legs, 2 weeks after a common cold. Dynamic skeletal scintigraphy with 780 MBq (20 mCi) Tc-99m HDP revealed increased perfusion and tracer uptake in the soft tissue of the lower legs, suggesting an inflammatory etiology. A muscle biopsy revealed a vasculitic necrotizing myopathy predominantly affecting the small vessels of the lower legs. We diagnosed it as a postinfectious immunologic reaction.

Topics: Adult; Biopsy; Common Cold; Electromyography; Female; Humans; Inflammation; Muscle, Skeletal; Muscular Diseases; Necrosis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Time Factors

Topics: Athletic Injuries; Femur; Humans; Knee Joint; Muscle, Skeletal; Muscular Diseases; Periostitis; Radioisotopes; Rheumatic Diseases; Running; Syndrome; Technetium Tc 99m Medronate; Tomography, Emission-Computed

Ga-67 scintigraphy is helpful in the assessment of active extrapulmonary sarcoidosis. Muscular involvement of sarcoidosis is often asymptomatic or nonspecific, and laboratory examinations do not provide convincing evidence of muscular involvement. The authors report a case of muscular sarcoidosis detected by Ga-67 scintigraphy. In a patient who had fever and arthralgia of both knee joints, Ga-67 scintigraphy showed mediastinal and hilar involvement of sarcoidosis with unexpected extensive muscular uptake. Magnetic resonance imaging revealed in detail intramuscular infiltration of sarcoid granuloma. Ga-67 scintigraphy is useful in detecting inflammatory muscular involvement of sarcoidosis and other multiorgan involvement.

Topics: Adult; Bone and Bones; Citrates; Gallium; Gallium Radioisotopes; Humans; Lung; Magnetic Resonance Imaging; Male; Muscle, Skeletal; Muscular Diseases; Radionuclide Imaging; Radiopharmaceuticals; Sarcoidosis; Technetium Tc 99m Medronate

Metastatic calcification associated with renal failure is well described. Bone scanning agents accumulate to various degrees within extraskeletal sites of metastatic calcification. The authors describe a patient with polycystic kidney disease resulting in renal failure, with the subsequent development of secondary hyperparathyroidism and metastatic calcification. Bone scintigraphy revealed abnormal uptake in both lungs, the right leg, and the right hand.

Topics: Calcinosis; Female; Hand; Humans; Hyperparathyroidism, Secondary; Kidney Failure, Chronic; Lung Diseases; Middle Aged; Muscular Diseases; Polycystic Kidney, Autosomal Dominant; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Technetium Tc 99m Sestamibi; Thigh; Thumb

A 26-year-old man with a previous history of external twin bursitis was remitted to our Department for a bone scintigraphy. Before the study, the patient performed an elevated number of intense sprints. Bone scintigraphy showed a bilaterally increased activity in both anterior rectum muscles suggesting rhabdomyolysis. Biochemical studies and MRT confirmed the diagnosis.

Topics: Adult; Bone and Bones; Humans; Joint Diseases; Magnetic Resonance Imaging; Male; Muscular Diseases; Pain; Radionuclide Imaging; Radiopharmaceuticals; Rhabdomyolysis; Running; Technetium Tc 99m Medronate

Benign myocardial uptake of technetium-99m labelled phosphates, not related to cardiac or metabolic disorders, has been documented except in the case of 99mTc-methylene diphosphonate (MDP). The aim of this study was to assess the frequency of myocardial uptake and its possible association with malignant tumours in general and prostatic carcinoma in particular. We reviewed bone scintigrams performed with either 99mTc-hydroxydiphosphonate (HDP) or 99mTc-MDP over a period of more than 2 years for all patients with prostatic carcinoma and a matching group of patients suffering from other malignant and non-malignant disorders. A total of 965 scintigrams of 812 patients (males = 559, females = 253; age range 50-91 years, average age 69.2 years) were reviewed. Increased myocardial uptake was detected in 19 scintigrams (MDP = 13, HDP = 6) of 18 patients (17 males, one female). Most of the male patients with increased myocardial uptake had prostatic carcinoma (13/17) and were over 80 years of age (12/17). All patients were free of any cardiac or noncardiac disorder that might account for such uptake. When scintigraphy was repeated in the same patient, the uptake of 99mTc-HDP was more diffuse and of higher grade than that of 99mTc-MDP. "Benign" myocardial uptake of 99mTc-MDP is more common than previously thought. Although uptake of radiophosphates is attributed to asymptomatic atherosclerotic changes associated with old age, a strong association with prostatic carcinoma exists which may indicate variations in the bone: soft tissue affinity of different MDP complexes.

Topics: Aged; Aged, 80 and over; Bone and Bones; Bone Diseases; Case-Control Studies; Female; Heart; Humans; Male; Muscular Diseases; Neoplasms; Prostatic Neoplasms; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Aged; Amyloidosis; Bone and Bones; Citrates; Citric Acid; Connective Tissue; Female; Gallium Radioisotopes; Humans; Male; Muscles; Muscular Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Adult; Diagnosis, Differential; Hematoma; Humans; Liposarcoma; Male; Muscular Diseases; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium Tc 99m Medronate

Topics: Adult; Bone and Bones; Calcinosis; Humans; Male; Muscular Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate; Uremia

An unusual distribution of Tc-99m MDP and Ga-67 citrate in several muscle groups is described in a 14-year-old boy with aplastic anemia and normal renal function at the time of imaging. Although the patient did not develop musculo-skeletal signs or symptoms, a subsequent autopsy revealed widespread muscle calcification.

Topics: Adolescent; Anemia, Aplastic; Calcinosis; Citrates; Citric Acid; Gallium; Gallium Radioisotopes; Humans; Male; Muscles; Muscular Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Bone and Bones; Gallium Radioisotopes; Muscular Diseases; Radionuclide Imaging; Sarcoidosis; Technetium Tc 99m Medronate

The aim of this work was to establish when, in the investigation of local musculoskeletal symptoms, dynamic isotope bone imaging yields useful information not available from static isotope bone imaging, using 99mTc methylene diphosphonate. One hundred and forty-two dynamic bone scans were reviewed, with particular reference to the site being imaged, the suspected underlying pathology, and the contribution of the dynamic phases to diagnosis, management, and eventual outcome. All were performed as part of the investigation of adult patients complaining of localized musculoskeletal symptoms. The dynamic phases influenced diagnosis, management, and eventual outcome most positively in suspected infection, particularly at a previous fracture site or around a prosthesis. They did not alter management significantly in suspected fracture, avascular necrosis, in most patients with pain of unknown cause, and were rarely helpful in imaging the axial skeleton. We suggest that, in the context of routine bone imaging, dynamic bone scanning should be reserved for cases of suspected infection. In the investigation of most other local bone pathologies, the static phase of the bone scan provides all the diagnostic information which is required for management decisions.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone and Bones; Bone Diseases; Bone Neoplasms; Child; Diagnosis, Differential; Hand; Humans; Knee Joint; Middle Aged; Muscular Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate; Time Factors

The accumulation of a bone-seeking radiopharmaceutical on delayed imaging in a hemangioma has not been described previously. The variable scintigraphic findings of hemangiomas are described in detail.

Topics: Adolescent; Arm; Hemangioma; Humans; Male; Muscular Diseases; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium Tc 99m Medronate

Topics: Adult; Female; Humans; Meperidine; Muscles; Muscular Diseases; Pentazocine; Radionuclide Imaging; Substance-Related Disorders; Technetium Tc 99m Medronate

Topics: Carcinoma, Squamous Cell; Diphosphonates; Humans; Hypopharyngeal Neoplasms; Male; Middle Aged; Muscular Diseases; Pharyngeal Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Diphosphonates; Forearm; Glycogen Storage Disease; Glycogen Storage Disease Type V; Humans; Ischemia; Middle Aged; Muscles; Muscular Diseases; Myoglobinuria; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Acute Kidney Injury; Adult; Bone and Bones; Calcinosis; Diphosphonates; Humans; Lung Diseases; Male; Muscular Diseases; Radionuclide Imaging; Stomach Diseases; Technetium; Technetium Tc 99m Medronate

Topics: Adult; Calcinosis; Diphosphonates; Humans; Hypocalcemia; Hypokalemia; Leg; Male; Muscles; Muscular Diseases; Radionuclide Imaging; Shoulder; Technetium; Technetium Tc 99m Medronate