technetium-tc-99m-medronate and Lymphoma--T-Cell

We report a patient with a sympathetic pleural effusion secondary to T-cell lymphoma that accumulated the bone imaging agent, Technetium-99m-methylene diphosphonate (99mTc-MDP). This case is significant in that malignant cells were not present on three cytologic examinations of the pleural fluid or multiple pleural biopsies. We also present a review of the published literature on pleural effusions that accumulate bone tracers. We conclude that pleural effusions that accumulate 99mTc-MDP should be considered malignant or secondary to a malignancy and further work-up is essential even if the cytologic exam of the pleural fluid is unremarkable.

Topics: Aged; Humans; Lymphoma, T-Cell; Male; Pleural Effusion, Malignant; Radionuclide Imaging; Technetium Tc 99m Medronate

Non-Hodgkin lymphoma (NHL) is rare in infancy, and we present a case of aggressive NHL of T-cell lineage in an infant with multifocal bone, cardiac, mediastinal nodal, paranasal sinus, calvarial, and soft-tissue deposits on presentation that were detected on whole-body MRI.

Topics: Bone Neoplasms; Heart Neoplasms; Humans; Infant; Lymph Nodes; Lymphoma, T-Cell; Magnetic Resonance Imaging; Male; Mediastinal Neoplasms; Paranasal Sinus Neoplasms; Radiopharmaceuticals; Skull Base Neoplasms; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Whole Body Imaging

Topics: Bone Neoplasms; Child; Citrates; Citric Acid; Female; Gallium; Gallium Radioisotopes; Humans; Lymphoma, T-Cell; Radionuclide Imaging; Technetium Tc 99m Medronate