technetium-tc-99m-medronate and Lymphoma--Non-Hodgkin

Tracheobronchopathia osteochondroplastica (TO) is a rare disorder with unknown aetiology. We report one case of TO in a patient with non-Hodgkin pulmonary lymphoma and benign epidermal and trichylemmal cysts on the periorbital region and scalp. To the authors' knowledge, the coincidence of these processes has never been described before. The case was evaluated with conventional X-ray, computed tomography, magnetic resonance imaging, fibre-optic bronchoscopy with 2 months interval, histopathological evaluation, Tc-99 m MDP bone scintigraphy and microbiological studies including PCR testing of bronchial biopsy and lavage specimens for Mycobacterium tuberculosis. Additionally, case reports of TO in the Turkish literature are summarized.

Topics: Aged; Biopsy; Bronchial Diseases; Bronchoalveolar Lavage Fluid; Bronchoscopy; CA-125 Antigen; Fatal Outcome; Female; Humans; Lung Diseases; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Osteochondrodysplasias; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Tracheal Diseases; Turkey

A 58-year-old man underwent Tc-MDP bone scintigraphy to evaluate the cause of diffuse bone pain. The images did not identify the exact cause of his symptoms. However, a "light bulb"-shaped urinary bladder and diffused increased activity in the scrotal region and left thigh were noted, which suggest a mass effect in the pelvis. A CT scan of the pelvis revealed soft tissue compressing the urinary bladder. A diagnosis of recurrent lymphoma was made.

Topics: Bone and Bones; Fluorodeoxyglucose F18; Humans; Lymphadenopathy; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Male; Middle Aged; Neoplasm Recurrence, Local; Pelvis; Positron Emission Tomography Computed Tomography; Radionuclide Imaging; Radiopharmaceuticals; Scrotum; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Urinary Bladder

99mTc-methylene diphosphonate (MDP) bone scan was performed in a 49-year-old female patient who had non-Hodgkin lymphoma. 99mTc-MDP uptake was significant in both lungs. Bilateral bacterial pneumonia associated with secondary hemophagocytic lymphohistiocytosis was diagnosed after extensive examination.

Topics: Female; Humans; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Non-Hodgkin; Middle Aged; Pneumonia; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Aged; Aged, 80 and over; Biopsy, Needle; Humans; Kidney Diseases; Lymphoma, Non-Hodgkin; Male; Radionuclide Imaging; Radiopharmaceuticals; Recurrence; Technetium Tc 99m Medronate; Ultrasonography

Topics: Adult; Biopsy; Bone Marrow; Bone Neoplasms; Diagnosis, Differential; Female; Humans; Lymphoma, Non-Hodgkin; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tonsillar Neoplasms

The authors report two cases of non-Hodgkin's lymphoma that were evaluated not only by conventional staging work-up but also additional Tc-99m MDP bone scans and fluorine-18 fluorodeoxyglucose (F-18 FDG) coincidence detection (CoDe) positron emission tomographic (PET) imaging. There were discordant results between the Tc-99m MDP bone scans and F-18 FDG CoDe PET. In the first case, the bone marrow biopsy was positive, and F-18 FDG CoDe PET was consistent with a malignancy, but the findings of the Tc-99m MDP bone scintiscan were negative. In the second case, the bone marrow biopsy was negative, but F-18 FDG CoDe PET revealed focal skeletal involvement, which improved markedly on the follow-up study after chemotherapy. If skeletal involvement has a focal distribution and is confined to the marrow cavity, both bone marrow biopsy and bone scintigraphy can be falsely negative. In this situation, F-18 FDG PET is useful and revealing.

Topics: Adult; Bone Marrow Neoplasms; False Negative Reactions; Female; Fluorodeoxyglucose F18; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed

Skeletal manifestation of Non-Hodgkin's lymphoma is rare in pediatric patients. Objective of the study was to determine imaging features, before and after treatment, and to correlate these features with clinical outcome.. A retrospective analysis of 1246 patients from two therapy studies (NHL-BMF-90 and 95) was performed. Imaging studies of 63 patients with bone involvement of lymphoma were reevaluated.. Incidence of initial bone involvement in Non-Hodgkin's lymphoma was 6.8%. Distribution was best assessed by bone scan, MRI revealed larger areas of marrow involvement and detected additional lesions. Sites of predilection were long bones of the lower extremities with epiphyseal involvement in 39%. Residual signal alterations in MRI after successful therapy remained in 71%. Osteonecrosis after therapy was a common finding. Clinical outcome war not correlated to the presence of bone involvement.. Since clinical outcome is not effected by bone involvement in childhood NHL, value of screening may be limited. Knowledge of imaging characteristics is mandatory for initial evaluation of primary osseous lymphomas and symptomatic lesions as well as for therapy controls.

Topics: Adolescent; Bone and Bones; Bone Neoplasms; Child; Humans; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Radionuclide Imaging; Radiopharmaceuticals; Retrospective Studies; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Treatment Outcome

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Humans; Leukemia, Promyelocytic, Acute; Lymphoma, Non-Hodgkin; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Spleen; Technetium Tc 99m Medronate

Topics: Breast Neoplasms; Female; Humans; Lymphoma, Non-Hodgkin; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Adult; Bone and Bones; Bone Neoplasms; False Positive Reactions; Female; Gallium Radioisotopes; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Male; Radionuclide Imaging; Retrospective Studies; Technetium Tc 99m Medronate

Topics: Adolescent; Arm; Bone and Bones; Extravasation of Diagnostic and Therapeutic Materials; Humans; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Male; Methotrexate; Radionuclide Imaging; Technetium Tc 99m Medronate

The diagnostic value of bone scintigraphy and radiography in the detection of lymphomatous bone involvement, and the role of bone scintigraphy in the evaluation of lymphomatous bone marrow involvement, were investigated in 41 patients with malignant lymphoma. 10 patients had lymphomatous bone involvement. Whereas scintigraphy detected all the 10 cases, radiography was false negative in 2 cases. The lytic bone lesions on radiography were in most cases not detected by scintigraphy. Scintigraphy is insensitive for the detection of early bone marrow metastases. The simultaneous use of bone scanning and x-ray, however, seems to be helpful in the detection of lymphomatous bone involvement and consequently in the clinical management of patients with malignant lymphoma.

Topics: Adolescent; Adult; Aged; Bone and Bones; Bone Marrow; Bone Neoplasms; Female; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Aged; Diagnosis, Differential; Femoral Neoplasms; Hip Prosthesis; Humans; Lymphoma, Non-Hodgkin; Male; Postoperative Complications; Prosthesis Failure; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Aged; Brain; Female; Gallium Radioisotopes; Humans; Lymphoma, Non-Hodgkin; Organotechnetium Compounds; Radionuclide Imaging; Skull Neoplasms; Sugar Acids; Technetium; Technetium Tc 99m Medronate; Thyroid Neoplasms

A total of 2530 consecutive bone scans were examined to evaluate the number and the type of soft tissue neoplasms detected with bone-seeking phosphonates. Sixty-eight primary or secondary soft tissue neoplasms of 63 patients accumulated 99mTc -methylene diphosphonate and 2 accumulated 99mTc -diphosphonate, and one metastasis was seen as a nonactive 'cold' focus in the urinary bladder. The localization of tumors was: 19 in the lung, 15 in the liver, 11 in the kidney, 10 in the peritoneal cavity or ascites, 5 in the large bowel, 4 in the vascular or lymphatic system, 3 in the connective tissue or muscles, 2 in the ovary, 1 in the urinary bladder, and 1 in the brain. Our results differ in many respects from those reported in the literature. The causes of the differences are discussed.

Topics: Abdominal Neoplasms; Adenocarcinoma; Adolescent; Adult; Aged; Bone and Bones; Carcinoma, Small Cell; Colonic Neoplasms; Diphosphonates; Female; Humans; Liver Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Retroperitoneal Neoplasms; Soft Tissue Neoplasms; Technetium; Technetium Compounds; Technetium Tc 99m Medronate

Topics: Adult; Bone Neoplasms; Diphosphonates; Female; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate