technetium-tc-99m-medronate and Liposarcoma

The presence of metaplastic ossification within atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) is a rare occurrence. When present, bone formation is most often found in association with a dedifferentiated component arising within the primary tumor. It is important for the radiologist not only to recognize the differential diagnosis of a calcified or ossified soft tissue mass but also be aware of the various soft tissue neoplasms, both aggressive and non-aggressive, that may show such features. We report a case of ALT/WDLPS with unusual extensive metaplastic bone formation without an element of dedifferentiated liposarcoma.

Topics: Aged; Biomarkers, Tumor; Biopsy, Needle; Cyclin-Dependent Kinase 4; Diagnosis, Differential; Humans; Liposarcoma; Magnetic Resonance Imaging; Male; Metaplasia; Ossification, Heterotopic; Positron-Emission Tomography; Proto-Oncogene Proteins c-mdm2; Radiography, Interventional; Radiopharmaceuticals; Shoulder; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Bone scintigraphy using (99m)TC MDP (technetium-99m methylene diphosphonate) is a routine procedure for evaluation of osteoblastic metastases; however, its sensitivity compared with FDG PET/CT in a variety of malignancies remains to be established. We report a case of multiple osseous metastases revealed by FDG PET/CT in an 8-year-old girl with pleomorphic liposarcoma. Many of these osseous lesions were not visualized on the MDP planar bone scintigraphy performed 24 hours after PET/CT scan, becoming evident only on repeat bone scan performed 3 months later. The case suggests that FDG PET/CT has higher sensitivity in detecting osteoblastic metastases in pleomorphic liposarcoma.

Topics: Bone and Bones; Bone Neoplasms; Child; Early Detection of Cancer; Female; Fluorodeoxyglucose F18; Humans; Liposarcoma; Multimodal Imaging; Positron-Emission Tomography; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Whole Body Imaging

Topics: Bone and Bones; Humans; Liposarcoma; Male; Middle Aged; Radionuclide Imaging; Retroperitoneal Neoplasms; Technetium Tc 99m Medronate

Topics: Adult; Diagnosis, Differential; Hematoma; Humans; Liposarcoma; Male; Muscular Diseases; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium Tc 99m Medronate

Topics: Aged; Humans; Knee; Liposarcoma; Male; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium Tc 99m Medronate

Accumulation of Tc-99m MDP in soft tissue malignancies occurs frequently. When tumor overlaps adjacent bone structures, the bone margins can be indiscernible on a regular bone scan. Additional views should be taken to differentiate bone from tumor, however, separation is sometimes difficult and not always successful. This report presents a patient in whom accumulation of Tc-99m MDP in a liposarcoma of the thigh disappeared on a 24 hour scan and bone margins were seen clearly. A possible mechanism for this phenomenon and its utility are discussed.

Topics: Adult; Female; Femoral Neoplasms; Humans; Liposarcoma; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Thigh; Time Factors

Topics: Diphosphonates; Female; Humans; Liposarcoma; Middle Aged; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Medronate; Thigh

Topics: Adult; Aged; Carcinoma, Squamous Cell; Child, Preschool; Diphosphonates; Female; Histiocytoma, Benign Fibrous; Humans; Liposarcoma; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Radionuclide Imaging; Rectal Neoplasms; Rhabdomyosarcoma; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Medronate; Thigh

Topics: Adult; Aged; Diphosphonates; Humans; Liposarcoma; Male; Radionuclide Imaging; Sarcoma, Synovial; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Medronate