technetium-tc-99m-medronate and Kidney-Neoplasms

Bone metastases are extremely rare in patients with classical Wilms' tumor (WT). We describe the clinical and radiologic features, treatment and outcome of three patients with WT (one with favorable histology and two with anaplasia) in whom bone metastases were detected at diagnosis or relapse. Bone metastases were documented by skeletal radiographs, computed tomography and/or bone scintigraphy. The patient with favorable histology WT had no evidence of pulmonary metastases and is now free of disease following aggressive chemotherapy and radiotherapy.

Topics: Biopsy, Needle; Bone Neoplasms; Child; Child, Preschool; Humans; Infant; Kidney Neoplasms; Lung Neoplasms; Male; Radionuclide Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Wilms Tumor

Extraosseous Tc-MDP uptake on bone scans is frequently encountered and has a broad differential diagnosis. A small subset of such patients can present with intestinal Tc-MDP uptake. We present the case of a 35-year-old woman with status after right nephrectomy for renal cell carcinoma, being followed with bone scan for osseous metastases. Follow-up imaging revealed new faint Tc-MDP uptake in the right hemiabdomen. Correlation with contrast-enhanced CT localized this uptake to the ascending colon. Enteric Tc-MDP uptake and its association with iodinated contrast should be considered in the differential diagnosis of extraosseous enteric Tc-MDP uptake.

Topics: Adult; Bone Neoplasms; Colon; Contrast Media; Diagnosis, Differential; Female; Humans; Kidney Neoplasms; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

A 57-year-old man with renal mass underwent Tc-diethylenetriaminepentaacetic acid renal dynamic scintigraphy for evaluation of renal function. The blood flow phase images demonstrated a focus of abnormal increased tracer uptake in the region of the right lower quadrant. On the functional phase images, the activity became unimpressive gradually. This focus corresponded to an osteolytic lesion in the right ilium on the CT and MR images, which was a typical pattern of bone metastasis.

Topics: Bone Neoplasms; Humans; Incidental Findings; Kidney; Kidney Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Technetium Tc 99m Medronate

The detection of occult bone metastases is a key factor in determining the management of patients with renal cell carcinoma (RCC), especially when curative surgery is considered. This prospective study assessed the sensitivity of (18)F-labelled sodium fluoride in conjunction with positron emission tomography/computed tomography ((18)F-NaF PET/CT) for detecting RCC bone metastases, compared with conventional imaging by bone scintigraphy or CT.. An adaptive two-stage trial design was utilized, which was stopped after the first stage due to statistical efficacy. Ten patients with stage IV RCC and bone metastases were imaged with (18)F-NaF PET/CT and (99m)Tc-labelled methylene diphosphonate ((99m)Tc-MDP) bone scintigraphy including pelvic single photon emission computed tomography (SPECT). Images were reported independently by experienced radiologists and nuclear medicine physicians using a 5-point scoring system.. Seventy-seven lesions were diagnosed as malignant: 100% were identified by (18)F-NaF PET/CT, 46% by CT and 29% by bone scintigraphy/SPECT. Standard-of-care imaging with CT and bone scintigraphy identified 65% of the metastases reported by (18)F-NaF PET/CT. On an individual patient basis, (18)F-NaF PET/CT detected more RCC metastases than (99m)Tc-MDP bone scintigraphy/SPECT or CT alone (P = 0.007). The metabolic volumes, mean and maximum standardized uptake values (SUV mean and SUV max) of the malignant lesions were significantly greater than those of the benign lesions (P < 0.001).. (18)F-NaF PET/CT is significantly more sensitive at detecting RCC skeletal metastases than conventional bone scintigraphy or CT. The detection of occult bone metastases could greatly alter patient management, particularly in the context when standard-of-care imaging is negative for skeletal metastases.

Topics: Aged; Bone Neoplasms; Carcinoma, Papillary; Carcinoma, Renal Cell; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Kidney Neoplasms; Male; Middle Aged; Multimodal Imaging; Neoplasm Staging; Positron-Emission Tomography; Prognosis; Prospective Studies; Radionuclide Imaging; Research Design; Sensitivity and Specificity; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Bone Neoplasms; Female; Fluorodeoxyglucose F18; Humans; Kidney Neoplasms; Male; Multimodal Imaging; Radionuclide Imaging; Research Design; Technetium Tc 99m Medronate

Topics: Bone Neoplasms; Carcinoma, Renal Cell; Fluorodeoxyglucose F18; Humans; Kidney Neoplasms; Middle Aged; Molecular Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Technetium Tc 99m Medronate

This study aims to compare the sensitivity of whole-body MRI with bone scintigraphy in the detection of bone metastases in patients with renal cancer. A prospective study was carried out in 47 patients with renal cancer (mean age 62 years, range 29-79 years). All patients had assessment of the skeleton with whole-body bone scintigraphy (with technetium-99m methylene diphosphonate) and whole-body MRI (coronal T(1) weighted and short tau inversion recovery sequences). The number and sites of bony metastases were assessed on each imaging investigation independently. Sites of extra-osseous metastasis on MRI were also noted. The imaging findings were correlated with other imaging modalities and follow-up. 15 patients (32%) had bone metastases at 34 different sites. Both scintigraphy and MRI were highly specific (94% and 97%, respectively), but the sensitivity of MRI (94%) was superior (p = 0.007) to that of scintigraphy (62%). MRI identified more metastases in the spine and appendicular skeleton, whereas scintigraphy showed more lesions in the skull/facial and thoracic bones. MRI identified extra-osseous metastases in 33 patients (70%), these were mainly lung and retroperitoneal in site. Whole-body MRI is a more sensitive method for detection of bone metastases in renal cancer than bone scintigraphy, and also allows the assessment of soft-tissue disease.

Topics: Adult; Aged; Bone Neoplasms; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Prospective Studies; Radionuclide Imaging; Radiopharmaceuticals; Sensitivity and Specificity; Technetium Tc 99m Medronate; Whole Body Imaging

The renal excretion of Tc-99m bone imaging agents often permits the identification of urinary tract abnormalities on bone scans. In this case report, identification of focal intrarenal stasis of the excreted bone imaging agent led to additional anatomic imaging and the identification of a renal medullary carcinoma (RMC) in an adolescent black male undergoing evaluation for back pain. RMC is a rare, highly aggressive renal neoplasm found almost exclusively in young individuals with sickle cell trait (SCT) or hemoglobin SC disease. The prognosis of RMC is poor because the malignancy is usually refractory to chemotherapy and radiotherapy, with metastatic disease commonly present at the time of diagnosis.

Topics: Adolescent; Bone and Bones; Carcinoma, Medullary; Humans; Kidney Neoplasms; Male; Sickle Cell Trait; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Topics: Adult; Aged; Aged, 80 and over; Bone Neoplasms; Breast Neoplasms; Esophageal Neoplasms; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Staging; Patient Satisfaction; Prospective Studies; Prostatic Neoplasms; Radiopharmaceuticals; Sensitivity and Specificity; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Tomography, Emission-Computed; Tomography, X-Ray Computed; Whole Body Imaging

Current imaging guidelines recommend that many cancer patients undergo soft-tissue staging by computed tomography (CT) whilst the bones are imaged by skeletal scintigraphy (bone scan). New CT technology has now made it feasible, for the first time, to perform a detailed whole-body skeletal CT. This advancement could save patients from having to undergo duplicate investigations. Forty-three patients with known malignancy were investigated for bone metastasis using skeletal scintigraphy and 16-detector multislice CT. Both studies were performed within six weeks of each other. Whole-body images were taken 4 h after injection of 500 Mbq (99m)Tc-MDP using a gamma camera. CT was performed on a 16-detector multislice CT machine from the vertex to the knee. The examinations were reported independently and discordant results were compared at follow-up. Statistical equivalence between the two techniques was tested using the Newcombe-Wilson method within the pre-specified equivalence limits of +/-20%. Scintigraphy detected bone metastases in 14/43 and CT in 13/43 patients. There were seven discordances; four cases were positive on scintigraphy, but negative on CT; three cases were positive on CT and negative on scintigraphy. There was equivalence between scintigraphy and CT in detecting bone metastases within +/-19% equivalence limits. Patients who have undergone full whole-body staging on 16-detector CT may not need additional skeletal scintigraphy. This should shorten the cancer patient's diagnostic pathway.

Topics: Adult; Aged; Aged, 80 and over; Bone Neoplasms; Breast Neoplasms; Esophageal Neoplasms; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Staging; Patient Satisfaction; Prospective Studies; Prostatic Neoplasms; Radiopharmaceuticals; Sensitivity and Specificity; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Tomography, Emission-Computed; Tomography, X-Ray Computed; Whole Body Imaging

Bone scans showing solitary hot spots in the ribs pose diagnostic problems in patients with proved extraskeletal cancers. The authors wanted to determine the importance of solitary rib lesions and their correlation with other clinical manifestations.. The study included 199 patients with solitary rib hot spots on their bone scans. The follow-up radiographic and scintigraphic images were reviewed to determine their origin. The correlation between the occurrence of a malignant rib lesion and clinical data were determined using Pearson chi-square tests.. Ninety-three patients had an established cause of the rib hot spot. Eleven (11.8%) had a solitary malignant rib hot spot and 82 (88.2%) had a solitary benign rib hot spot. None of the hot spots at costochondral junctions were malignant. Of the 11 patients with proved metastatic rib hot spots, 1 of 11 (9.1%) had localized bone pain, 5 of 6 (83.3%) were concordant with primary tumors, 4 of 7 (57.1%) had elevated tumor markers, and 5 of 11 (45.5%) had concurrent extraskeletal metastases. For the 82 patients with benign rib hot spots, the figures were 2 of 82 (2.4%), 43 of 57 (75.4%), 26 of 69 (37.7%), and 19 of 82 (23.2%), respectively. Statistical analysis did not show a significant correlation between the incidence of metastases in solitary rib hot spots and clinical manifestations.. Most solitary rib hot spots on bone scans were benign. The interpretation of a solitary hot spot in the ribs is difficult even with the help of these clinical manifestations. Follow-up bone scintigrams or radiographs are needed for further investigation of solitary rib hot spots.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Bone Diseases; Bone Neoplasms; Breast Neoplasms; Diagnosis, Differential; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Retrospective Studies; Ribs; Statistics as Topic; Technetium Tc 99m Medronate

Conventional technetium-99m methylene diphosphate whole body bone scan (bone scan) has a high sensitivity but a poor specificity to detect bone metastases. However, positron emission tomography with 18F-2-deoxyglucose (FDG-PET) can offer superior spatial resolution and improved specificity. We have attempted to evaluate the usefulness of FDG-PET for detecting bone metastases in renal cell carcinomas (RCC) and to compare FDG-PET results with bone scan findings.. Eighteen patients were selected for this study with biopsy-proven RCC. They were suspected of having bone metastases and were undergoing bone scan and FDG-PET to detect bone metastases. The final diagnoses of bone metastases were established by operative, histopathological findings or clinical follow-up longer than 1 year by additional radiographs or following FDG-PET/bone scan findings showing progressive and extensive widespread bone lesions.. A total of 52 bone lesions including 40 metastatic and 12 benign bone lesions found on either FDG-PET or bone scan were evaluated. FDG-PET could accurately diagnose all 40 metastatic and 12 benign bone lesions. Bone scan could accurately diagnose only 31 metastatic bone lesions. Diagnostic sensitivity and accuracy of FDG-PET were 100% and 100%, respectively,and bone scan were 77.5% and 59.6%, respectively.. Our data suggest that FDG-PET has a higher sensitivity and a better accuracy than that of bone scan to detect bone metastases in patients with RCC.

Topics: Aged; Bone Neoplasms; Carcinoma, Renal Cell; Female; Fluorodeoxyglucose F18; Humans; Kidney Neoplasms; Male; Middle Aged; Technetium Tc 99m Medronate; Tomography, Emission-Computed

Topics: Arthritis, Rheumatoid; Bone and Bones; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Vena Cava, Inferior

In order to investigate the feasibility of the assessment of renal function with 99mTc-MDP, we compared renographical images, renogram patterns and the glomerular filtration rate (GFR) obtained by means of a modified Gates' method and 200 MBq of 99mTc-MDP with those obtained by means of 99mTc-DTPA. Because 19 of 20 patients had malignant tumors in the genitourinary tract, there was no difference between the two tracers in identifying a parenchymal defect corresponding to renal cancer. Of eight patients with hydronephrosis, four had a defect or decreased uptake with a dilated pelvis, whereas the other four had marked radioisotope retention in the renal pelvis or the whole kidney on serial images. There was also no difference between the two tracers in identifying hydronephrosis. Of 38 paired renograms 35 showed the same renogram patterns with both tracers. Of three patients with different renogram patterns, two had hydronephrosis. In 20 patients including three patients with bone metastasis, total GFR and split GFR obtained with both tracers correlated with a correlation coefficient of r = 0.920 (p < 0.001) and r = 0.944 (p < 0.001), respectively. Excluding bone metastasis from the analysis, a linear-regression analysis showed excellent agreement between the two measurements with a correlation coefficient of r = 0.960 (p < 0.001) and r = 0.963 (p < 0.001), respectively. The linear regression equations were Y = 1.009X - 0.111 and Y = 1.034X - 0.714, respectively. In conclusion, 99mTc-MDP can be used as a supplement to evaluate renal function incidental to the survey of bone metastases in patients with malignant tumor.

Topics: Aged; Aged, 80 and over; Blood Urea Nitrogen; Bone and Bones; Bone Neoplasms; Creatinine; Female; Glomerular Filtration Rate; Humans; Hydronephrosis; Kidney; Kidney Neoplasms; Male; Middle Aged; Prostatic Neoplasms; Radioisotope Renography; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tissue Distribution; Urinary Bladder Neoplasms; Urogenital Neoplasms

We present a case of renal cell carcinoma metastasis to the skull, appearing as a photopenic area on Tc-99m MDP bone scan and with focal uptake in the same region on Tc-99m MIBI imaging.

Topics: Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Skull Neoplasms; Technetium Tc 99m Medronate; Technetium Tc 99m Sestamibi

Topics: Artifacts; Bone and Bones; Carcinoma, Transitional Cell; Female; Follow-Up Studies; Humans; Kidney Neoplasms; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Urinary Bladder Neoplasms; Urinary Reservoirs, Continent; Urinary Tract

Nephron-sparing surgery has become established as an effective treatment for localized renal cell carcinoma when preservation of renal function is necessary. The surgery usually requires temporary renal artery occlusion and may induce ischemic renal damage. In this study, we retrospectively evaluated renal activity on bone scintigraphy after nephron-sparing surgery.. Eleven patients who underwent nephron-sparing surgery for renal cell carcinoma and had a normal contralateral kidney were studied. A total of 12 bone scintigraphy images with 99mTc-labeled methylene diphosphonate were obtained within 1 y after surgery in these patients to assess skeletal metastasis. Activity in the spared renal parenchyma was compared visually with that in the contralateral normal kidney.. The tumor was successfully resected in every patient, and no clinically significant complications occurred. Activity in the spared renal parenchyma was elevated in six of seven examinations performed within 21 d after surgery. In three examinations, the increase in renal activity was heterogeneous, being relatively prominent near the surgical margin. Increased renal activity was not observed on five examinations performed 3 mo or more after surgery.. Renal retention of bone-seeking agents is elevated in the early period after nephron-sparing surgery, probably as a result of ischemic insult during the surgical procedure. Bone scintigraphy may aid in evaluating the presence and degree of ischemic damage of the spared renal parenchyma.

Topics: Adult; Bone and Bones; Bone Neoplasms; Carcinoma, Renal Cell; Female; Humans; Kidney; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Retrospective Studies; Technetium Tc 99m Medronate

Topics: Bone and Bones; Carcinoma, Renal Cell; Colonic Diseases; Female; Gastrointestinal Hemorrhage; Humans; Kidney Neoplasms; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Whole-Body Counting

This case report describes the clinical, scintigraphic, and pathologic findings in a patient with an unexpected finding of a cutaneous malignant melanoma.. Multiple imaging studies were done, as was a pathologic examination of a suspicious pigmented lesion on the patient's back.. A Tc-99m MDP bone scan showed diffuse uptake in the skeleton, lungs, kidneys, and stomach.. Metastatic calcification, as shown by isotope scintigraphy, is an unusual manifestation of metastatic cancer from a primary cutaneous melanoma.

Topics: Adult; Bone and Bones; Female; Humans; Kidney Neoplasms; Lung Neoplasms; Melanoma; Radionuclide Imaging; Radiopharmaceuticals; Renal Insufficiency; Skin Neoplasms; Stomach Neoplasms; Technetium Tc 99m Medronate

Focal renal concentration of radioactivity can simulate metastatic deposits in the lower ribs on bone scintigrams. 400 consecutive bone scintigrams were reviewed for focal areas of increased tracer activity in the kidneys. 62 patients (15.5%) had at least one renal hot spot. In 42 of these 62 patients (67.7%) there was an increased focal uptake in the left kidney (18 upper pole, 18 middle pole and six lower pole). 50 out of 62 bone scans (80.7%) showed increased activity in the right kidney (14 upper pole, 32 middle pole and four lower pole). With the incidence of focal areas of activity in the upper poles of the kidneys being 8%, the interpretation of a single focal abnormality projected over the lower ribs should be made with particular care, especially in cancer patients.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone Neoplasms; Child; Diagnosis, Differential; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasms, Unknown Primary; Radionuclide Imaging; Retrospective Studies; Ribs; Technetium Tc 99m Medronate

Topics: Adult; Female; Gallium Radioisotopes; Humans; Kidney Neoplasms; Liver Neoplasms; Lymph Nodes; Lymphoma, B-Cell; Radionuclide Imaging; Splenic Neoplasms; Technetium Tc 99m Medronate

We describe herein a case of parathyroid carcinoma accompanied with metastatic calcification identified by technetium-99m methylene diphosphonate (Tc-99m MDP) scintigraphy in the lungs, kidneys and stomach. Parathyroid carcinoma remains a rare disorder despite the increased prevalence of primary hyperparathyroidism. Metastatic calcification is noted infrequently even in primary hyperparathyroidism and it may cause respiratory failure. Tc-99m MDP scintigraphy three months after surgery showed a complete disappearance of Tc-99m uptake in the stomach and an obvious reduction in the kidneys but no significant change in the lungs, indicating metastatic calcification can be reversibly reabsorbed. This case indicates that the adequate excision of parathyroid carcinoma as well as the early detection of metastatic calcification by Tc-99m MDP are obligatory.

Topics: Calcinosis; Carcinoma; Female; Humans; Hypercalcemia; Kidney Neoplasms; Lung Diseases; Middle Aged; Neoplasm Invasiveness; Parathyroid Neoplasms; Radionuclide Imaging; Respiratory Insufficiency; Stomach Diseases; Technetium Tc 99m Medronate

Topics: Adult; Bone and Bones; Carcinoma, Hepatocellular; Diagnosis, Differential; Female; Humans; Kidney Neoplasms; Liver Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Spherocytosis, Hereditary; Spleen; Splenectomy; Technetium Tc 99m Medronate

Bone scintigraphy performed to assess the significance of an incidental finding of a small sclerotic rib lesion on a chest radiograph of a patient with no known malignancy demonstrated no evidence of metastatic disease, but there was moderate diffuse parenchymal retention in the left kidney. Renal ultrasound revealed an ovoid, slightly hyperechoic mass in the inferior pole of the left kidney, and subsequent contrast CT demonstrated a well-circumscribed hypervascular mass in that location. At nephrectomy, a localized 1.5-cm diameter clear-cell epithelial neoplasm, not definitely malignant, was found. No other abnormalities were noted in the remainder of the left kidney or in the surrounding soft tissues. No calcifications or other parenchymal changes in the kidney were identified to explain the retention of the bone agent, which was possibly related to the hyperemia associated with the neoplasm and undefined parenchymal factors.

Topics: Aged; Bone and Bones; Humans; Kidney; Kidney Neoplasms; Male; Radionuclide Imaging; Ribs; Technetium Tc 99m Medronate

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Bone and Bones; Carcinoma, Renal Cell; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Staging; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Adult; Budd-Chiari Syndrome; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms; Liver; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Neoplastic Cells, Circulating; Radionuclide Imaging; Renal Veins; Technetium Tc 99m Medronate; Vena Cava, Inferior

Topics: Carcinoma, Renal Cell; Female; Humans; Kidney; Kidney Neoplasms; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Bone and Bones; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Low Back Pain; Neoplasm Recurrence, Local; Radionuclide Imaging; Technetium Tc 99m Medronate

A patient with breast metastases is presented showing increased nodular renal uptake of tracer on bone scintigraphy that also demonstrated rib metastases and a large metastasis in the pelvis. However, vertebral body metastases were not shown when clearly demonstrated on CT with even partial compression on a thoracic spine film. Most of the renal lesions were hypoechoic on sonography, showed hypoattenuation areas on plain CT and after contrast enhancement but no calcification could be demonstrated. This case once again illustrates the value of scrutinizing the soft tissues on scintigraphy but also the possibility of showing some metastases on CT not visible on scintigraphy.

Topics: Adult; Bone and Bones; Breast Neoplasms; Female; Humans; Kidney; Kidney Neoplasms; Radionuclide Imaging; Spinal Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Ultrasonography

Ninety-one radiologically confirmed osteolytic metastases in 30 patients with hypernephromas were studied with regard to their uptake of 99mTc-MDP and this was compared with the radiological findings. In 16% of the radiologically proven metastases, there was no correlation with their isotope uptake. Compared with other bone metastases whose isotope uptake has been studied and described in the literature, there appears to be a higher proportion of hypernephroma secondaries that do not show uptake of 99mTc-MDP.

Topics: Adult; Aged; Bone Neoplasms; Carcinoma, Renal Cell; Evaluation Studies as Topic; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Aged; Bone Neoplasms; Female; Humans; Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms, Multiple Primary; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Adult; Diagnosis, Differential; Dysgerminoma; Humans; Kidney; Kidney Neoplasms; Male; Radionuclide Imaging; Retroperitoneal Neoplasms; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Teratoma; Testicular Neoplasms

Topics: Abdominal Muscles; Adenocarcinoma; Humans; Kidney Failure, Chronic; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Postoperative Care; Technetium Tc 99m Medronate

A case of huge renal cell carcinoma with localization of a skeletal imaging agent is presented. Two unusual scintigraphic findings of bone agent localization in the tumor were observed: a ring-like configuration, and low-intensity uptake. The large ring-like appearance of the extraosseous radioactivity may reflect a bulky tumor with central necrosis and a less active calcification process.

Topics: Aged; Bone Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Radionuclide Imaging; Technetium Tc 99m Medronate

A clinically and radiographically unsuspected ossified renal metastasis from a primary osteogenic sarcoma was identified by computed tomography (CT) and radionuclide bone scan. These imaging modalities play an important adjunctive role in the evaluation and follow-up of patients with primary osteogenic sarcoma.

Topics: Adolescent; Diphosphonates; Female; Femoral Neoplasms; Humans; Kidney Neoplasms; Osteosarcoma; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Skeletal scintigraphy is useful for detecting primary renal carcinomas and associated osseous metastatic deposits. Usually, renal masses present as photon-deficient foci, and osseous metastases, as foci of increased response. A case is presented with the unusual combination of focal increased Tc-99m MDP localization to the primary renal cell carcinoma and photopenic osseous metastatic foci. Proposed mechanisms are discussed.

Topics: Adult; Bone Neoplasms; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Male; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone and Bones; Breast Neoplasms; Cisplatin; Diphosphonates; Esophageal Neoplasms; Humans; Kidney; Kidney Neoplasms; Radionuclide Imaging; Tamoxifen; Technetium; Technetium Tc 99m Medronate

Solitary lesions on bone scans obtained as part of metastatic diagnostic studies for genitourinary malignancy require identification as to whether they represent nonneoplastic or neoplastic disease and, if neoplastic, whether metastatic genitourinary cancer or another primary is present. Such definition requires at least plain film tomograms of the area as well as computerized tomography (for inaccessible lesions) and/or biopsy of lesions still in doubt after tomography. Of the 9 patients in our study 4 had true positive scans for metastatic disease, 3 had false positive scans, 1 had a true positive scan for a second bone primary and 1 is indeterminate, since a negative biopsy of a positive area on a bone scan was followed rapidly by the appearance of other widespread metastases.

Topics: Adenocarcinoma; Adult; Aged; Bone Neoplasms; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Diphosphonates; False Positive Reactions; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Prostatic Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Urinary Bladder Neoplasms; Urogenital Neoplasms

Patients with prostatic cancer frequently require evaluation of bony metastases as well as renal function. 99mTc-methylene diphosphonate, a commonly used bone-imaging agent, is about 60 per cent localized in the bony skeleton and about 40 per cent excreted by the kidneys. Immediate imaging after intravenous injection of the isotope may yield high-quality radionuclide nephrourograms, which provide excellent visual and graphic displays of renal anatomy and excretory function. Our preliminary studies suggest that the immediate 99mTc-methylene diphosphonate scan may usefully expand the value of a routine bone scan to screen for ureteral obstruction. Patients with underlying malignancy who require simultaneous evaluation and follow-up of bony metastases and renal function might be conveniently served by the dual functions of the expanded bone scan to include immediate imaging of the kidneys.

Topics: Adenocarcinoma; Aged; Bone Neoplasms; Diphosphonates; Humans; Kidney; Kidney Neoplasms; Male; Middle Aged; Prostatic Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Ureteral Neoplasms; Ureteral Obstruction

Topics: Abdomen; Aged; Cysts; Diphosphonates; Female; Humans; Inflammation; Kidney Neoplasms; Male; Middle Aged; Pain; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Ureteral Calculi; Urine; Urologic Diseases

Topics: Aged; Bone Neoplasms; Diphosphonates; Humans; Kidney; Kidney Diseases; Kidney Neoplasms; Male; Middle Aged; Pilot Projects; Prostatic Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Time Factors; Urinary Bladder Neoplasms; Urodynamics

Forty-two bone images carried out on 33 patients with renal carcinoma have been evaluated. The bone image seems more sensitive than conventional radiology in detecting bone secondaries, but covert metastases are unlikely in the patient presenting with purely urological symptoms.

Topics: Bone and Bones; Bone Neoplasms; Diphosphonates; Humans; Kidney Neoplasms; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

68 metastatic bone lesions proven by biopsy, follow-up radionuclide bone imaging, or radiographs in 18 patients with surgically confirmed renal cell carcinoma were retrospectively analyzed. Bone imaging demonstrated 62 lesions (91%): 48 definite, 7 questionable 'hot' lesions, and, 2 definite, 5 questionable 'cold' lesions. The spine was the most common site. 15 patients had more than one metastasis. 27 lesions were undiscovered by radiographs. Serum alkaline phosphatase was elevated in 12 of 18 patients. It is concluded that radionuclide bone imaging is more sensitive than radiographic examination for bony metastasis from renal cell carcinoma, and that it is important to recognize 'cold' metastatic lesions on the bone imaging in patients with renal cell carcinoma.

Topics: Adenocarcinoma; Bone Neoplasms; Diphosphonates; Humans; Kidney Neoplasms; Radiography; Radionuclide Imaging; Retrospective Studies; Technetium; Technetium Tc 99m Medronate

Topics: Child; Diagnosis, Differential; Diphosphonates; Humans; Kidney Neoplasms; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Wilms Tumor

Tc-99m labeled dimethyl-amino-diphosphonate (DMAD) was compared with methylene diphosphonate (MDP) in five healthy volunteers and 28 patients with a variety of bony afflictions. Although the normal bone uptake of DMAD is less than MDP, the lesion-to-normal bone ratio is significantly higher with DMAD. All 71 lesions detected with MDP were also seen with DMAD. However, 10 lesions were disclosed with DMAD that were not seen with MDP. These lesions tended to have low grade concentrations of the radiopharmaceutical and were detected with DMAD by virtue of the lower normal bone uptake rather than higher lesion uptake.

Topics: Adult; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Humans; Kidney Neoplasms; Lung Neoplasms; Middle Aged; Multiple Myeloma; Organotechnetium Compounds; Osteitis Deformans; Osteomyelitis; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Technetium-99m methylene diphosphonate (99mTc MDP) imaging was performed in 29 consecutive children with abdominal masses. Dynamic images of the inferior vena cava were obtained by injecting the radiotracer in the feet. Serial renal images were obtained for the next 30 min. Routine bone imaging was performed at about 3 hr. The radionuclide studies of the inferior vena cava accurately diagnosed total obstruction and displacement to the left but not partial obstruction and displacement to the right. The abnormalities on early renal imaging included displacement (14), distortion (seven), obstruction (eight), and nonvisualization (one). All patients with Wilms tumor (eight) had either nonvisualized or distorted renal parenchyma. Patients with neuroblastoma (17) and other tumors (four) had displacement and obstruction. Soft-tissue accumulation of 99mTc MDP was noted in two Wilms tumors and 12 neuroblastomas.

Topics: Abdominal Neoplasms; Child; Diphosphonates; Humans; Kidney Neoplasms; Neuroblastoma; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Vena Cava, Inferior; Wilms Tumor

Topics: Adenocarcinoma; Adult; Aged; Bone and Bones; Diphosphonates; Female; Gallium Radioisotopes; Humans; Kidney; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Succimer; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Medronate

Topics: Adenocarcinoma; Aged; Diphosphonates; Female; Humans; Kidney Neoplasms; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Medronate

Technetium-99m-sodium medronate is commonly used for skeletal imaging. Renal excretion allows evaluation of the kidneys. Renal masses present as areas of diminished activity. In the cases described, a renal carcinoma showed increased radionuclide accumulation, probably because of extensive tumor calcification.

Topics: Carcinoma; Diphosphonates; Female; Humans; Kidney Neoplasms; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Aged; Bone Neoplasms; Diphosphonates; Humans; Kidney; Kidney Neoplasms; Male; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Carcinoma, Squamous Cell; Diphosphonates; Humans; Kidney Neoplasms; Lung Neoplasms; Male; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

The kidneys and urinary tracts were evaluated in 465 patients during the course of skeletal scintigraphy. In 45 cases suspicion was aroused and in 35 abnormalities were demonstrated in the kidneys, ureters or bladder. In six patients the suspicion of an abnormality could not be confirmed on pathologic, urologic or radiologic examinations. In four patients absence of activity in the kidneys was due to disseminated osteoblastic metastases. In half these cases (17 patients) these findings had not been suspected. The appearances of various renal and urinary tract abnormalities, as seen on a bone scintigram, have been classified into five categories. The most common appearance is that of obstruction. The value of paying attention to the kidneys and urinary tract in the course of bone scintigrams is stressed.

Topics: Bone and Bones; Diphosphonates; Humans; Kidney; Kidney Neoplasms; Osteoma, Osteoid; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Urinary Tract