technetium-tc-99m-medronate and Kidney-Diseases

We conducted this retrospective study to explore whether abnormalities on renal images obtained using whole-body bone scintigraphy (WBS) can help detect renal diseases.. Patients who underwent WBS between June 2017 and October 2018 were screened and then underwent a minimum 6-month follow-up, during which their clinical information was tracked. The percentage of different renal abnormalities, diseases, and intervention considerations was calculated.. We screened 4706 WBS examinations, and 486 (10.3%) patients exhibited abnormalities on renal images. The major types of abnormal renal images obtained via WBS included images of diffuse increased uptake (10.9% [53/486]), focal increased uptake (65.6% [319/486]), diffuse decreased uptake (8.0% [39/486]), focal decreased uptake (10.7% [52/486]), heterogeneous uptake (3.3% [16/486]), and small kidney size (1.4% [7/486]). After a 6-month follow-up period, 65.4% (318/486) of our included patients exhibited confirmed kidney abnormalities that included calculus, urine accumulation, cyst, atrophy, severe hydronephrosis, and tumors. Among these patients with confirmed kidney abnormalities, 27.4% (87/318) had newly identified renal abnormalities, 11.9% (38/318) underwent further examinations by clinicians, and 7.9% (25/318) received further intervention and treatment, including surgery and chemotherapy.. Although renal images obtained with WBS could not be used to accurately evaluate kidney conditions, abnormal renal images obtained with WBS may indicate that serious renal problems exist. Therefore, both nuclear medicine physicians and clinicians should pay more attention to renal abnormalities on WBS. Patients with renal abnormalities should undergo dedicated renal examinations with WBS, which may change clinical decision-making.

Topics: Bone and Bones; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Kidney Diseases; Male; Radionuclide Imaging; Radiopharmaceuticals; Retrospective Studies; Technetium Tc 99m Medronate; Whole Body Imaging

The aim of this study is to clarify the period of extraosseous accumulation of (99m)Tc-hydroxymethylenediphosphonate (HMDP) to radiation nephropathy mimicking recurrent or remnant neuroblastoma in the pararenal region.. We reviewed five neuroblastoma and one ganglioneuroblastoma patients (2 boys and 4 girls aged 1-9 years) who underwent (99m)Tc-HMDP bone scintigraphies periodically before and after radiation therapy.. Increased renal uptake coincident with the radiation port appeared in 5 of 6 patients from 0 to 3 months (mean 1.7 months), and persisted up to 7 months after the completion of radiotherapy. Renal uptake of (99m)Tc-HMDP was gradually decreased, and eventually became accumulation defects in 5 of 6 patients from 6 to 17 months (mean 8.9 months) after radiotherapy.. When extraosseous accumulation is found after radiation therapy in neuroblastoma patients, radiation nephropathy would be a candidate in the differential diagnosis besides recurrent or remnant tumor.

Topics: Bone Neoplasms; Child; Child, Preschool; Diagnosis, Differential; Diagnostic Errors; Female; Humans; Infant; Kidney; Kidney Diseases; Male; Neoplasm Recurrence, Local; Neuroblastoma; Radiation Injuries; Radionuclide Imaging; Radiopharmaceuticals; Radiotherapy; Technetium Tc 99m Medronate

Tc-99m hydroxymethylene disphosphonate administered for skeletal scintigraphy may be seen in the extraosseous tissues for various etiologies. This report presents similar abnormal lower extremity skeletal muscle uptake in 2 patients status postorthotopic liver transplant. Although the history and scintigraphic appearance of the 2 were similar, subtle differences in cutaneous lesions and histology led to disparate diagnoses.

Topics: Fibrosis; Graft vs Host Disease; Humans; Kidney Diseases; Liver Transplantation; Male; Middle Aged; Muscle, Skeletal; Radionuclide Imaging; Radiopharmaceuticals; Skin Diseases; Technetium Tc 99m Medronate

Topics: Aged; Aged, 80 and over; Biopsy, Needle; Humans; Kidney Diseases; Lymphoma, Non-Hodgkin; Male; Radionuclide Imaging; Radiopharmaceuticals; Recurrence; Technetium Tc 99m Medronate; Ultrasonography

Topics: Aged; Bone and Bones; Dehydration; Diagnostic Errors; Humans; Kidney; Kidney Diseases; Male; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Metastatic calcification is often detected by bone scintigraphy. We recently saw metastatic calcification in the stomach and kidneys of a patient on continuous ambulatory peritoneal dialysis. Tc-99m HMDP accumulation into both organs was noted even in the first frame of dynamic data acquisition of 4 min/frame, suggesting that calcium deposits may create an aggressive process and we may obtain information on the calcium deposit rate to better understand the mechanism of metastatic calcification.

Topics: Aged; Bone and Bones; Calcinosis; Calcium; Female; Humans; Kidney Diseases; Peritoneal Dialysis, Continuous Ambulatory; Radiopharmaceuticals; Stomach Diseases; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Cholelithiasis; Diagnosis, Differential; Female; Humans; Kidney Diseases; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Bone and Bones; Child, Preschool; Diverticulum; Humans; Kidney Calices; Kidney Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Adolescent; Diverticulum; Humans; Kidney Diseases; Male; Radionuclide Imaging; Technetium Tc 99m Medronate; Technetium Tc 99m Pentetate

A collimated whole-body counter was used to measure the retention and distribution of radioactivity along the longitudinal axis of the body at several times during the 24 hours after the intravenous injection of 50 microCi of Tc-99m-diphosphonates. Whole-body retention (WBR) was measured together with regional uptakes in the following four areas: head, chest, bladder, and legs using two structurally related Tc-99m-diphosphonate skeletal imaging agents: 1-hydroxyethylidene diphosphonate (HEDP) and methylene diphosphonate (MDP). The average 24 hour WBR values in young males, reflecting skeletal uptake of these tracers, were 17.7 +/- 2.2% (n = 20) and 31.0 +/- 2.4% (n = 3), respectively. A model of skeletal clearance was developed using the sum of two exponentials. In normal volunteers the initial rapid clearance phase of both tracers had a half-time of about 1 hour, whereas the slower second phase clearance had a half-time of 22 hours with HEDP and 44 hours with MDP. The WBR is usually calculated for the entire body only at 24 hours, but with the improved spatial resolution of a collimated whole-body counter, regional measurements could potentially be done over shorter periods (6-8 hours) in order to simplify the procedure.

Topics: Bone and Bones; Bone Diseases; Etidronic Acid; Humans; Kidney Diseases; Male; Organotechnetium Compounds; Technetium; Technetium Tc 99m Medronate; Whole-Body Counting

Skeletal, reticuloendothelial and renal images were obtained on a patient with osteopetrosis using Tc-99m MDP, Tc-99m HSA millimicrospheres and Tc-99m DTPA respectively. The bone scan showed increased uptake in multiple fracture sites, in the frontal bone, and in the splayed metaphyses of long bones while the remainder of the skeleton appeared normal. Reticuloendothelial images demonstrated an absence of bone marrow activity, hepatosplenomegaly and a site of extramedullary hematopoiesis. A renogram demonstrated a left kidney displaced and distorted by the massive splenomegaly.

Topics: Adult; Fractures, Bone; Humans; Kidney Diseases; Male; Mononuclear Phagocyte System; Organometallic Compounds; Osteopetrosis; Pentetic Acid; Radionuclide Imaging; Technetium; Technetium Tc 99m Aggregated Albumin; Technetium Tc 99m Medronate; Technetium Tc 99m Pentetate

Renal images shown on 254 bone scans employing Tc 99m MDP were analyzed to evaluate the renal abnormalities. Among these cases, there were 43 cases of abnormal renal visualization. Of these abnormal cases, 27 cases were proved by laboratory data, radiographs, echograms, CT findings and autopsy records. 14 cases of renal abnormalities were presented; hydronephrosis due to ureteral obstruction (4 cases), renal dysfunction (3 cases), renal cell carcinoma (2 cases), contracted kidney (2 cases), nephrectomy (2 cases) and renal stone (1 case). Three cases showed super bone images with widespread metastatic lesions of malignant tumors. The remaining 10 cases were not revealed renal abnormalities from other clinical findings.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bone and Bones; Child; Female; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Radionuclide Imaging; Retrospective Studies; Technetium Tc 99m Medronate

Topics: Abscess; Foot Diseases; Humans; Kidney Diseases; Middle Aged; Radionuclide Imaging; Skin Ulcer; Technetium Tc 99m Medronate

Patients with diffuse increased accumulation in both kidneys on 99mTc-MDP bone scintigram were evaluated quantitatively. Among 1,100 cases, 7 (0.63%) showed this finding. The accumulation density ratios of kidneys/lumbal vertebra in A/D exchanged images of these patients were compared with control group, so that these ratios of patient group were higher than control group statistically. In conclusion, the accumulation density ratio was made the index of diffuse increase accumulation in both kidneys on 99mTc-MDP bone scintigram.

Topics: Adult; Aged; Bone and Bones; Child, Preschool; Female; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Adult; Aged; Bone and Bones; Evaluation Studies as Topic; Female; Humans; Kidney Diseases; Male; Middle Aged; Radionuclide Imaging; Retrospective Studies; Technetium Tc 99m Medronate; Ureteral Diseases

Topics: Acromegaly; Adult; Aged; Bone and Bones; Bone Diseases, Metabolic; Connective Tissue; Female; Femur; Humans; Hyperthyroidism; Kidney Diseases; Male; Middle Aged; Radionuclide Imaging; Renal Dialysis; Skull; Technetium Tc 99m Medronate

Topics: Aged; Bone Neoplasms; Diphosphonates; Humans; Kidney; Kidney Diseases; Kidney Neoplasms; Male; Middle Aged; Pilot Projects; Prostatic Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Time Factors; Urinary Bladder Neoplasms; Urodynamics

A fast diagnosis (6h) of clinically latent pyonephrosis by combined use of 99mTc-MDP and 67Ga-citrate is reported. This technique combines the potential early detection of focal infectious processes by 67Ga and the "high-pulse" separation possibility of multiple isotopes. A brief prospective study (6 months) showed the interest of this technique: in six cases focal bone and/or joint infections were found three of which were absolutely latent clinically.

Topics: Adult; Diphosphonates; Female; Fever of Unknown Origin; Gallium Radioisotopes; Humans; Kidney Diseases; Prospective Studies; Proteus Infections; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Time Factors