technetium-tc-99m-medronate and Hypertrophy

From January 1988 to May 1990, 60 patients underwent 68 total hip arthroplasties at the Eisenhower Army Medical Center. The authors excluded 11 patients (11 hips) in whom infection developed, who were lost to followup, or who had incomplete records, leaving 49 patients (57 hips) as the study population. The 35 uncemented and 22 cemented femoral stems were evaluated with technetium bone scans at 1 week, 6 months, 1 year, and 2.5 years after surgery. Patients with uncemented femoral stems had markedly more thigh pain and more radiopharmaceutical uptake around the stem tip at 2.5 years followup than did patients with cemented femoral stems. In addition, patients with thigh pain had more uptake around the stem tip and a higher incidence of bone hypertrophy around the stem tip than did those without thigh pain, suggesting stress transfer as a cause of thigh pain.

Topics: Adult; Aged; Cementation; Femur; Follow-Up Studies; Hip Joint; Hip Prosthesis; Humans; Hypertrophy; Middle Aged; Pain, Postoperative; Prospective Studies; Prosthesis Design; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Thigh

The aims of this study were to determine the incidence of hypertrophic pulmonary osteoarthropathy (HPO) in nasopharyngeal carcinoma (NPC) and assess its clinical significance. Altogether, 407 NPC patients were reviewed retrospectively. HPO was identified by 99Tcm-methylene diphosphonate bone scans and related clinical and radiographic evidence. Pulmonary metastases, bony metastases and titre of anti-Epstein Barr virus (EBV) immunoglobulin were assessed in patients with and without HPO. The patients had a mean (+/- S.D.) age of 50.4 +/- 12.4 (range 17-73) years. HPO was found in 27 of the 407 (6.6%) NPC patients, among whom 13 (48%) had pulmonary metastases. HPO preceded lung metastases by 7-22 months (14.4 +/- 6 months) in 7 (52%) patients. Six patients had overt lung metastases at the time of the bone scan. No significant difference was found in anti-EBV immunoglobulins between the patients with or without HPO, nor in the incidence of bony metastases between these two groups of patients. HPO should be regarded as an early sign of pulmonary metastases.

Topics: Adolescent; Adult; Aged; Antibodies, Viral; Bone Diseases; Bone Neoplasms; Child; Herpesvirus 4, Human; Humans; Hypertrophy; Lung Diseases; Lung Neoplasms; Middle Aged; Nasopharyngeal Neoplasms; Osteoarthropathy, Secondary Hypertrophic; Radionuclide Imaging; Reproducibility of Results; Retrospective Studies; Technetium Tc 99m Medronate

We compared growth in vascularised allograft transplants, autografts and in non-operated physes in rabbits immunosuppressed with cyclosporin A and in non-immunosuppressed animals. Molecular haplotyping was undertaken before operation to ensure allogenicity. Postoperative bone scans and fluorochrome labelling were used to confirm physeal vascularity. The animals were killed at three or five weeks. Proximal tibial physeal autografts, with or without cyclosporin A, or allografts with cyclosporin A, grew at similar rates to the physes of non-operated rabbits. All the operated physes grew at rates significantly greater than their contralateral controls. 99mTc-MDP bone scans accurately predicted the viability of the epiphyseal plate. Quantitative histomorphological analysis of the heights of the physeal proliferative and hypertrophic zones showed that successful physeal transplants have a normal appearance, but when unsuccessful have thickened hypertrophic zones compatible with physeal ischaemia. We discuss the significance of these results in relation to the transplantation of physes in children.

Topics: Analysis of Variance; Anastomosis, Surgical; Animals; Cyclosporine; Follow-Up Studies; Growth Plate; Hypertrophy; Immunosuppression Therapy; Ischemia; Microsurgery; Polymorphism, Restriction Fragment Length; Rabbits; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate; Tibia; Transplantation, Autologous; Transplantation, Homologous

Topics: Bone and Bones; Child; Female; Humans; Hypertrophy; Kidney; Radionuclide Imaging; Technetium Tc 99m Medronate

Hypertrophic pseudarthrosis was studied with Tc-99m MDP and Ga-67 citrate in 11 patients. Two of the 11 pseudarthroses were complicated by infection. A high concentration of both radiopharmaceuticals was obtained at all 11 sites and their distribution patterns were identical. It was therefore impossible to distinguish the infected from the noninfected pseudarthroses by using Ga-67.

Topics: Bacterial Infections; Diphosphonates; Gallium Radioisotopes; Humans; Hypertrophy; Pseudarthrosis; Radiography; Radionuclide Imaging; Retrospective Studies; Technetium; Technetium Tc 99m Medronate

Topics: Adult; Diphosphonates; Female; Humans; Hypertrophy; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Thoracic Vertebrae