technetium-tc-99m-medronate and Hyperplasia

Topics: Acquired Hyperostosis Syndrome; Bone Neoplasms; Face; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Hyperplasia; Infections; Mandibular Condyle; Maxilla; Osteitis Deformans; Periodontitis; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals; Sjogren's Syndrome; Technetium Tc 99m Medronate; Technology, Dental; Temporomandibular Joint Disorders; Tomography, X-Ray Computed

In unilateral condylar hyperplasia, for surgical intervention to be effective, the status of condylar bone growth has to be assessed correctly. Previously this assessment relied on serial clinical observations. This study aimed to evaluate the MDP-SPECT method of assessing condylar growth in unilateral condylar hyperplasia. Twenty-six MDP-SPECT of the mandible had been performed; 21 were diagnosed as condylar hyperplasia and five as non-mandibular disease. Three isotope parameters: isotope counts, pixel counts and counts per pixel were summed for each condyle per subject. The percentage difference in isotope uptake of the three parameters between the two condyles was calculated as the ratio of the combined counts of the two sides. These differences significantly correlated with each other (Pearson r=0.78-0.98) and with the clinical status of bone growth (Spearman rho=0.72-0.86). There was a significant difference for the count per pixel between the 'growing' condyle (transaxial, T: 15.05+/-7.14, coronal, C: 12.29+/-7.88), the 'no further growth' condyle (T: 5.22+/-4.08, C: 5.67+/-3.88) and the 'normal' condyle (T: 0.82+/-0.76, C: 1.34+/-0.66). This method was able to separate 'active growth' from 'growth cessation' of the condyle by a single MDP-SPECT of the mandible. However, further studies are needed to confirm this finding.

Topics: Adult; Cephalometry; Female; Humans; Hyperplasia; Male; Mandible; Mandibular Condyle; Mandibular Diseases; Middle Aged; Observer Variation; Predictive Value of Tests; Prospective Studies; Radiopharmaceuticals; Statistics, Nonparametric; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Bone scintigraphy is an extremely valuable technique in diagnosis and treatment planning for patients with condylar hyperplasia (CH). The main objective of this study was to develop an approach to determine normal activity values in the mandibular condyles, adjusted to age and sex, through quantitative analysis of bone single-photon emission computed tomography (SPECT) on a condyle-by-condyle basis and to compare these values with those of a control group comprising patients with confirmed CH. Technetium 99 m-methylene diphosphonate (

Topics: Humans; Hyperplasia; Mandible; Mandibular Condyle; Reference Values; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

The purpose of this study is to evaluate the utility of hybrid single-photon emission computed tomography (SPECT) and computed tomography (CT) with technetium-99m methylene diphosphonate in patients with suspected active unilateral condylar hyperplasia (UCH) using histopathology as the reference standard.. Twenty-four patients with suspected active UCH prospectively underwent technetium-99m methylene diphosphonate planar bone scintigraphy with SPECT/CT of the mandible. Qualitative and quantitative readings for growth activity were performed by 3 nuclear medicine physicians and the final diagnosis was derived from postoperative histopathological examination. Readings were reported as positive, equivocal, or negative. Total, maximum, and mean counts were recorded for each condyle on SPECT/CT images. The uptake of the index (suspected) condyle was expressed as a count ratio (R. Interobserver agreement was 0.79 and 0.83 for planar bone scintigraphy and SPECT/CT, respectively, with a total of 5 and 1 equivocal readings from the respective modalities. Surgery was performed in 22 patients; all of them had pathologically proven UCH. SPECT/CT was slightly more sensitive than planar bone scintigraphy (91 vs 78%) with identical specificity (96%). R. Quantitative approaches based on total or mean count ratio or relative count percentage were equally predictive for UCH diagnosis; however, they were slightly less sensitive compared with qualitative technetium-99m methylene diphosphonate SPECT/CT evaluation. SPECT/CT evaluation has the potential to decrease the equivocal readings.

Topics: Humans; Hyperplasia; Mandibular Condyle; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Multiple intravascular papillary endothelial hyperplasia involved with bone is rare. In this study, we present the case of a 53-year-old woman having occasional chest pains located in the middle of the sternum and the left chest wall. Multiple intravascular papillary endothelial hyperplasia lesions with high metabolism distributed in the sternum, left ribs, 12th thoracic vertebra, and left ilium on bone scintigraphy as well as PET/CT, which were easily misdiagnosed as bone malignant tumors. Increased awareness of this benign lesion and its high metabolic findings will improve preoperative diagnosis and avoid misinterpretation that may lead to an unnecessary invasive treatment.

Topics: Bone and Bones; Bone Neoplasms; Diagnosis, Differential; Endothelial Cells; Female; Fluorodeoxyglucose F18; Humans; Hyperplasia; Middle Aged; Positron Emission Tomography Computed Tomography; Technetium Tc 99m Medronate

Topics: Adolescent; Adult; Child; Child, Preschool; Facial Asymmetry; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Young Adult

To evaluate the incremental value of technetium-99m methylene diphosphonate (Tc-MDP) single-photon emission computed tomography/computed tomography (SPECT/CT) over planar bone scintigraphy (BS) and SPECT for the diagnosis of active condylar hyperplasia (CH).. Data of 21 patients (mean age: 21.9±5.3 years, 10 males, 11 females) who underwent Tc-MDP BS along with regional SPECT/CT for the diagnosis of active CH were retrospectively evaluated. Planar BS, SPECT, and SPECT/CT images were evaluated by two nuclear medicine physician in consensus. Radioactive counts were measured per region of interest and the respective ratios were calculated. A percentage of condylar uptake 55% or higher, generating differences of 10% or more between condyles, was considered to be indicative of active unilateral condylar hyperactivity. Sensitivity, specificity, and positive and negative predictive values were calculated separately for planar BS, SPECT, and SPECT/CT. Clinical/imaging follow-up and histopathology was considered the reference standard.. Planar BS, SPECT, and SPECT-CT of 21 patients with suspected CH were retrospectively evaluated. Planar BS was positive in eight patients, of whom six had active CH as the final diagnosis. SPECT was positive in 14 patients, of whom 12 patients had CH. Out of 14 patients who were positive in SPECT, two patients were considered negative in SPECT-CT. The diagnostic accuracy was the lowest for planar BS (47.6%) and the highest for SPECT/CT (85.8%). SPECT/CT and SPECT had similar sensitivity (80%), whereas SPECT-CT had the highest specificity (100%).. SPECT/CT is superior to planar BS and SPECT for the diagnosis of active CH.

Topics: Adolescent; Adult; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Radiopharmaceuticals; Retrospective Studies; Single Photon Emission Computed Tomography Computed Tomography; Technetium Tc 99m Medronate; Young Adult

Bone scintigraphy (BS) has been the mainstay in evaluating patients with mandibular condylar hyperplasia (CH). Both planar BS and single photon emission computed tomography (SPECT) have been used to determine cessation of condylar hyperactivity before corrective surgery. The present study aimed to examine the utility of the relatively new single photon emission computed tomography/computed tomography (SPECT/CT) technique for evaluation of CH.. Sixty-one mandibular Tc-99m methylene diphosphonate bone SPECT/CT studies were reviewed. Images were analyzed without and with fusion with anatomical CT. Condylar uptake were quantified and differences in uptake between the right and left condyles were determined by both maximum uptake and average uptake in the region of interes (ROI). Differences exceeding 10 percentage points indicated condylar hyperactivity.. SPECT and SPECT/CT showed positivity in 34 and 31 examinations, respectively. Agreement between the two modalities was high, but was not perfect. SPECT was found to be more reproducible than SPECT/CT. Quantification using maximum ROI counts was more reproducible than using average ROI counts.. No evidence was found to indicate superiority of SPECT/CT over simple SPECT for evaluation of condylar\ hyperactivity in CH, as demonstrated by the lower intra-modality reproducibility and a trend towards lower sensitivity for detection of hyperactive condyles. Utilization of SPECT alone would further benefit in terms of reduction of patient radiation exposure which is a concern, especially in younger patients such as those with CH. When using quantification, maximum ROI counts should be used over average ROI counts.

Topics: Adolescent; Adult; Female; Humans; Hyperplasia; Male; Malocclusion; Mandibular Condyle; Reproducibility of Results; Retrospective Studies; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tooth Abnormalities; Young Adult

The aim of this study was to compare the reliability and correlations with age and gender of two nuclear medicine tests used for diagnosis of active condylar hyperplasia, namely, planar bone scintigraphy versus single photon emission computed tomography (SPECT).. This was a descriptive observational study carried out in 61 patients (38 women and 23 men) clinically diagnosed as having facial asymmetry and suspected unilateral condylar hyperplasia. The patients had both planar bone scintigraphy and SPECT diagnostic imaging as well as reference data of the percentage of (99)Tc(m) MDP (methylenediphosphonate) uptake in the condyle, clivus, and fourth lumbar vertebra (L4), respectively, for SPECT and planar scintigraphy calculations. Radioactive counts were measured per region of interest and the respective ratios were calculated. The age range of the patients was 13-50 years (mean ± standard deviation = 21.16 ± 8.75). The two groups were compared by a nonparametric (Mann-Whitney U test. Uptake percentage and delta values had normal distribution and consequently were compared by a Student t test.. A total of 61 anterior planar images and 61 SPECT images were compared. Eight patients presented high uptake in planar bone scintigraphy images (13.11%), while 32 patients (52.46%) had high uptake with SPECT. The prevalence of condylar hyperactivity was higher in women than in men both for right condyle (ratio 4:3) and for left condyle (10:1) and the prevalence was significantly higher for the right condyle.. The study indicates that SPECT is more sensitive to identify condylar hyperactivity as compared to planar bone scintigraphy in patients with clinical presumptive diagnostic of condylar hyperplasia.

Topics: Adolescent; Adult; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Middle Aged; Reproducibility of Results; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Young Adult

The aims of the study were to evaluate the diagnostic accuracy and utility of the mean region of interest (ROI) and mean and maximum volume of interest (VOI) analysis methods for

Topics: Adult; Aged; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Middle Aged; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

This study assessed the quantitative evaluation of the region of interest (ROI) by mean and maximum pixel counts of single-photon emission computed tomography (SPECT) scans in patients with clinical suspicion of unilateral condylar hyperactivity (UCH); the interobserver reliability and the correlation of condylar activity with patient age was determined.. Two independent observers analyzed 67 bone SPECT scans. Maximum and mean activity values within an ROI on the mandibular condyle were analyzed; a cutoff value of 55% was used to determine the qualitative outcome.. Excellent interobserver agreement was seen for both maximum (kappa 1.0) and mean activity analysis (kappa 0.94). Maximum and mean condylar activities were strongly correlated (r > 0.98). Maximum and mean condylar activity of the normal condyle decreased significantly with increasing age.. Maximum and mean condylar activity levels were highly correlated in patients with mandibular asymmetry. An excellent interobserver agreement was found with either maximum or mean condylar activity.

Topics: Adolescent; Adult; Age Factors; Child; Facial Asymmetry; Female; Humans; Hyperplasia; Image Processing, Computer-Assisted; Male; Mandibular Condyle; Observer Variation; Radiopharmaceuticals; Reproducibility of Results; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Young Adult

We report a case of condylar hyperplasia diagnosed with 99mTc-MDP SPECT/CT. A 21-year-old woman with facial asymmetry was referred for assessment of condylar growth activity. SPECT/CT confirmed condylar hyperactivity, and simultaneous low-dose CT contributed to the diagnosis of hemimandibular hyperplasia. SPECT/CT may become a valuable tool for the diagnosis and comprehensive assessment of condylar hyperplasia, providing both functional and morphological information.

Topics: Facial Asymmetry; Female; Humans; Hyperplasia; Mandibular Condyle; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Young Adult

Topics: Cephalometry; Child; Facial Asymmetry; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Models, Dental; Orthodontics, Corrective; Radiopharmaceuticals; Retrospective Studies; Technetium Tc 99m Medronate; Temporomandibular Joint; Tomography, Emission-Computed, Single-Photon; Treatment Outcome

This study compares quantitative analysis of planar bone scintigrams with visual interpretation in patients having unilateral condylar hyperplasia (UCH) and normal control subjects. The possibility of using a bony structure in a region near the condyle as an objective measurement of bone activity is assessed.. Planar bone scintigrams from 20 subjects suspected of having active UCH were analyzed both qualitatively and quantitatively. Bone activity was assessed in both condyles as well as in reference sites in the cervical spine and the skull. Percentile activities for both condyle regions and ratios using condyle activity versus reference regions were assessed.. All UCH patients had unilateral increased activity on qualitative visual interpretation of the bone scan. The mean percentile activities of the affected and unaffected condyles in the UCH group were significantly different at 55.3% and 44.7%, respectively (P < .001). No significant difference was found in the control group, with the ratios between left and right condyle being 49.5% and 50.5%, respectively (P = .46). In the ratios between the region of interest (ROI) in the condyles versus the ROIs selected for the cervical spine and the skull, a significant difference was noticed in the UCH group; however, there was a considerable overlap between condyle and reference ROI ratios. Symmetrical uptake of diphosphonate reliably excluded continued asymmetrical growth of the condyles.. Quantitative analysis of planar scintigrams in unilateral condylar hyperplasia patients was not found to be superior to qualitative visual interpretation of the scans. Because of a considerable overlap in condyle/reference ROI ratios, quantified ratios did not seem to be clinically helpful in the differentiation of a hyperplastic condyle from a normal condyle. In the case of unilateral increased condylar uptake of diphosphonate, clinical assessment is mandatory.

Topics: Adult; Case-Control Studies; Cervical Vertebrae; Facial Asymmetry; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Radionuclide Imaging; Radiopharmaceuticals; Retrospective Studies; Skull; Technetium Tc 99m Medronate; Temporomandibular Joint Disorders

Treatments to correct skeletal deformities in patients with hemimandibular hyperplasia differ, particularly about the age at which the operation is done and the operation itself. To some extent, the differences can be attributed to the unknown biological basis of disease. The aim of the present study was to evaluate clinically the outcome of a rationale for the operation based on condylectomy on the affected side. Histological, radiological, and nuclear methods were used to get a more detailed insight into the reason for the operation. Six patients with hemimandibular hyperplasia were treated by a combined orthodontic-maxillofacial protocol. All patients had the affected joint removed. The histological morphology of each condylar specimen was compared with the bone scintigraphy to try and find a correlation between the methods. The clinical evaluation showed morphological and functional rehabilitation of all six patients. During the 2-year follow-up, all patients had stable symmetrical mandibles with no disturbance of temporomandibular function. Remodelling of the joint and the destruction of the cartilaginous layer was accompanied by much bone scintigraphic activity. We conclude that condylectomy can correct hemimandibular hyperplasia, even in patients with active condylar growth, by removing the underlying disease.

Topics: Adult; Cartilage, Articular; Cephalometry; Facial Asymmetry; Female; Humans; Hyperplasia; Jaw Abnormalities; Male; Malocclusion; Mandible; Mandibular Condyle; Oral Surgical Procedures; Orthodontics, Corrective; Osteotomy, Le Fort; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Treatment Outcome

Topics: Adult; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Mandibular Diseases; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Diagnosis, Differential; Female; Humans; Hyperplasia; Middle Aged; Osteomyelitis; Parathyroid Diseases; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Technetium Tc 99m Sestamibi; Thoracic Vertebrae

Isotope bone scans have been used for a number of years to assess growth activity in the mandibular condyle in patients who present with facial asymmetry. The aim is to distinguish normal bone growth within the condyle from increased activity that may be the cause of the asymmetry. Previous studies have, however, relied only on planar images. SPECT (single photon emission computed tomography) has been used with quantitative assessments of one mandibular condyle to clivus or lumbar spine, but we have compared one condyle with the other, which is more sensitive and accurate in detecting abnormal activity. A relative percentage uptake of 55% or more in the affected mandibular condyle is considered to be abnormal, and this has been validated by comparison with an age-matched control group. We have used SPECT as an aid to diagnosis and treatment in 18 patients with asymmetrical growth and have constructed a therapeutic algorithm to aid the treatment of these patients.

Topics: Adolescent; Adult; Case-Control Studies; Child; Cranial Fossa, Posterior; Facial Asymmetry; Female; Follow-Up Studies; Humans; Hyperplasia; Lumbar Vertebrae; Male; Malocclusion; Mandibular Condyle; Osteotomy; Radiopharmaceuticals; Reproducibility of Results; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Acquired Immunodeficiency Syndrome; Blood; Bone Marrow; CD4 Lymphocyte Count; Granulocyte Colony-Stimulating Factor; Humans; Hyperplasia; Knee Joint; Leukopenia; Pelvic Bones; Radionuclide Imaging; Radiopharmaceuticals; Spine; Technetium Tc 99m Medronate; Whole-Body Counting

Fibrous dysplasia is a benign bone disorder. It is diagnosed by distinctive X-ray radiography, CT, and MRI findings. Although bone scintigraphy helps to identify the tumor origin according to accelerated bone turnover, the glucose metabolism in fibrous dysplasia has not yet been investigated. We reported a case of fibrous dysplasia in craniofacial bone which showed signs of the acceleration of bone mineral turnover without elevated glucose utilization by Technetium-99m-HMDP SPECT and Fluorine-18-FDG PET. We concluded that the growth of fibrous dysplasia needed the acceleration of bone mineral turnover without an increase in glucose metabolism.

Topics: Bone Density; Facial Bones; Female; Fibrous Dysplasia, Polyostotic; Fluorodeoxyglucose F18; Glucose; Humans; Hyperplasia; Middle Aged; Radiopharmaceuticals; Sclerosis; Skull; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

A prospective study was designed to compare two methods of quantifying technetium-99m methylene diphosphonate uptake in the mandibular condyle. The standard technique expresses condylar activity as a ratio of condylar uptake to a reference (often the fourth lumbar vertebra) with planar scans (lateral images of the mandible). The experimental technique quantifies condylar activity as a ratio of condyle to clivus uptake with single-photon emission computed tomography (SPECT). The results of this study indicated that the uptake ratio of condyle/clivus by SPECT scintigram was positively correlated (p = 0.039) with the planar scan technique. The SPECT technique, similar to an axial computed tomography scan, was easier to perform with better reproducibility than the standard planar technique. In addition, activity in the clivus showed less variation than activity in the fourth lumbar vertebrae. With the development of normal uptake standards in the clivus, the SPECT technique may replace the planar image technique in nongrowing patients.

Topics: Adolescent; Adult; Bone Resorption; Cohort Studies; Cranial Fossa, Posterior; Female; Humans; Hyperplasia; Linear Models; Lumbar Vertebrae; Male; Mandibular Condyle; Mandibular Diseases; Middle Aged; Osteoarthritis; Prospective Studies; Radionuclide Imaging; Reference Standards; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Scintigaphy using 99mTc-MDP is widely advocated as a method of diagnosis and presurgical assessment of patients with condylar hyperplasia. A previous study has demonstrated that hyperplasia of the mandibular condyle is characterized histologically by the presence of an uninterrupted layer of undiffentiated germinative mesenchyme cells, a layer of hypertrophic cartilage and the presence of islands of chondrocytes in the subchondral trabecular bone. This study was undertaken to determine whether there was any association between the degree of 99mTc-MDP uptake and the histological features of condylar hyperplasia. The parameters examined were trabecular bone volume, depth of cartilage islands and the presence of forming and resorbing surfaces. The images were analyzed by three experienced observers, who ranked the images according to degree of asymmetry between sides and the degree of uptake on the affected side. There was a significant correlation between the proportions of resorbing and osteoid covered bone surfaces and scintigraphic appearances. The rank correlations were rs = 0.55 (P = 0.3) between the resorptive surfaces and degree of symmetry and rs = 0.53 (P = 0.04) between the osteoid surfaces and absolute uptake. The correlation was higher for both methods (rs = 0.64 in each case) when the osteoid surface and resorptive surface measurements were combined. The results indicate that visual examination of radioisotope bone scans by experienced observers is a valid form of assessment of bone activity in condylar hyperplasia.

Topics: Adolescent; Adult; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Mandibular Diseases; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate; Temporomandibular Joint Disorders

This investigation was undertaken to correlate the scintigraphic and histological features of condylar hyperplasia to identify consistent diagnostic findings. A series of 34 surgically excised condyles were examined from a 5 year period. Of these, 20 were diagnosed clinically and histologically as condylar hyperplasia. In 18 of these the presentation was one of increasing facial asymmetry. In all 20 cases there was an increased uptake of Technetium 99 as determined by gamma scintigraphy. The thickness of the fibrous articular layer, undifferentiated germinal mesenchyme layer and the hyperplastic cartilage layer were measured using an eyepiece graticule and the presence and frequency of islands of cartilage in the subchondral bone were noted. 7 patients received tetracycline hydrochloride 14 and 4 days pre-operatively in an attempt to quantify the calcification rate. An uninterrupted layer of undifferentiated germinal mesenchyme is a consistent feature of condylar hyperplasia. An increased uptake on scintigraphy is proportionally related to the thickness of the hypertrophic cartilage and not only to the presence but also the frequency of cartilage islands in the subchondral bone.

Topics: Adolescent; Adult; Cartilage; Facial Asymmetry; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Mandibular Diseases; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate

Bone scintiscans comparing the uptake of technetium 99 in the normal and affected condyles of 10 patients with unilateral condylar hyperplasia were recorded at or after the time when overall growth had ceased. The scans of 6 patients demonstrated persisting increased growth activity at this time. In 2 of these cases where the abnormal condyles showed uptakes of 240% and 170% with respect to the normal side, the nature and timing of treatment were changed when the results of the scans were known.

Topics: Adolescent; Adult; Facial Asymmetry; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Osteotomy; Radionuclide Imaging; Technetium Tc 99m Medronate; Time Factors

Radionuclide skeletal scintigraphy has been successfully used in the assessment of mandibular condylar hyperplasia (condylar hyperplasia) causing mandibular asymmetry to identify the presence of continued active growth in the condylar region. This study reviews 14 cases of mandibular asymmetry and concludes that symmetrical radionuclide uptake in the condylar regions on the bone scintigram excludes a continuing asymmetrical growth focus. Unilateral increased radionuclide uptake may often indicate an abnormally active condylar growth focus but false positive results may be encountered in patients with associated temporo-mandibular joint disease.

Topics: Adult; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Adolescent; Adult; Computers; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Patient Care Planning; Radionuclide Imaging; Technetium Tc 99m Medronate

Four patients with maxillo-mandibular facial dysharmony and four controls were evaluated by 99Tcm-MDP (methyl diphosphonate) scintiscanning. The scintiscans in all patients with dysharmony showed positive uptake of the tracer indicating the increased degree of activity in the condylar region of the mandible. The significance of this is discussed.

Topics: Adolescent; Adult; Diphosphonates; Facial Asymmetry; Female; Humans; Hyperplasia; Male; Mandibular Condyle; Maxillofacial Development; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Adolescent; Diphosphonates; Female; Humans; Hyperplasia; Mandibular Condyle; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate