technetium-tc-99m-medronate and Hydronephrosis

In order to investigate the feasibility of the assessment of renal function with 99mTc-MDP, we compared renographical images, renogram patterns and the glomerular filtration rate (GFR) obtained by means of a modified Gates' method and 200 MBq of 99mTc-MDP with those obtained by means of 99mTc-DTPA. Because 19 of 20 patients had malignant tumors in the genitourinary tract, there was no difference between the two tracers in identifying a parenchymal defect corresponding to renal cancer. Of eight patients with hydronephrosis, four had a defect or decreased uptake with a dilated pelvis, whereas the other four had marked radioisotope retention in the renal pelvis or the whole kidney on serial images. There was also no difference between the two tracers in identifying hydronephrosis. Of 38 paired renograms 35 showed the same renogram patterns with both tracers. Of three patients with different renogram patterns, two had hydronephrosis. In 20 patients including three patients with bone metastasis, total GFR and split GFR obtained with both tracers correlated with a correlation coefficient of r = 0.920 (p < 0.001) and r = 0.944 (p < 0.001), respectively. Excluding bone metastasis from the analysis, a linear-regression analysis showed excellent agreement between the two measurements with a correlation coefficient of r = 0.960 (p < 0.001) and r = 0.963 (p < 0.001), respectively. The linear regression equations were Y = 1.009X - 0.111 and Y = 1.034X - 0.714, respectively. In conclusion, 99mTc-MDP can be used as a supplement to evaluate renal function incidental to the survey of bone metastases in patients with malignant tumor.

Topics: Aged; Aged, 80 and over; Blood Urea Nitrogen; Bone and Bones; Bone Neoplasms; Creatinine; Female; Glomerular Filtration Rate; Humans; Hydronephrosis; Kidney; Kidney Neoplasms; Male; Middle Aged; Prostatic Neoplasms; Radioisotope Renography; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tissue Distribution; Urinary Bladder Neoplasms; Urogenital Neoplasms

Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Diagnosis, Differential; False Positive Reactions; Female; Humans; Hydronephrosis; Iodine Radioisotopes; Iodobenzenes; Middle Aged; Organotechnetium Compounds; Pheochromocytoma; Radionuclide Imaging; Radiopharmaceuticals; Succimer; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Medronate; Technetium Tc 99m Pentetate; Tomography, X-Ray Computed; Urography

We prospectively evaluated routine bone scintigraphs to determine the prevalence of radiotracer retention in the renal collecting system, and to test the reliability of this finding as an indicator of obstructive uropathy. Post-diuretic renal washout was also measured, to evaluate the use of this procedure after bone scintigraphy. Stasis occurring only in the supine position was excluded by obtaining upright images. The findings on bone scintigraphy were compared with the results of renal sonography. Patients showing persistent pelvicaliceal concentration in the upright position after bone scintigraphy were found to have evidence of obstructive uropathy by sonography or other studies. Furosemide administration was followed by washout of the bone tracer from all kidneys with proven partial ureteral obstruction. Persistent renal pelvicaliceal concentration, in upright images after bone scintigraphy, appears to be a reliable indicator of obstructive uropathy. However, measurement of post-diuretic renal washout, after bone scintigraphy, does not reliably detect obstructive uropathy, and may be misleading if interpreted in the same way as the standard diuretic renogram.

Topics: Aged; Aged, 80 and over; Bone and Bones; Furosemide; Humans; Hydronephrosis; Male; Middle Aged; Posture; Radionuclide Imaging; Technetium Tc 99m Medronate; Ureteral Obstruction

Endometriosis is a common disorder, affecting women in the child-bearing years. While urologic involvement is rare, the bladder is more often affected than the ureter. The authors describe the case of a 30-year-old woman who had unilateral ureteral obstruction secondary to an isolated periureteral retroperitoneal area of endometriosis. The theories of histogenesis are discussed. Current treatment consists of surgery or hormonal manipulation or a combination of the two.

Topics: Adult; Diphosphonates; Endometriosis; Female; Humans; Hydronephrosis; Radionuclide Imaging; Retroperitoneal Neoplasms; Technetium; Technetium Tc 99m Medronate; Ultrasonography; Ureteral Obstruction

Topics: Aged; Colonic Diseases; Colonic Neoplasms; Diphosphonates; Humans; Hydronephrosis; Intestinal Fistula; Male; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Ureteral Diseases; Urinary Fistula