technetium-tc-99m-medronate and Granuloma

Two cases of Erdheim-Chester disease are presented: a 26-year-old white male patient with lipoidgranulomatosis of numerous long and flat bones and infiltration of pericardium, pleura, liver, spleen, thyroid, skin, conjunctiva, gingiva, and false vocal cord; and a 54-year-old white male with involvement of bones, orbits, brain, pericardium, and retroperitoneum. The scintigraphic findings in this disease are described, and a comprehensive review of the 27 previously reported cases is given including an assessment of the value of scintigraphy for diagnosis and follow up of this rare disease.

Topics: Adult; Bone Diseases; Cholesterol; Follow-Up Studies; Granuloma; Humans; Lipidoses; Male; Middle Aged; Radionuclide Imaging; Syndrome; Technetium Tc 99m Medronate; Technetium Tc 99m Sulfur Colloid

To describe a 55-year-old male with Erdheim-Chester disease with bilateral orbital infiltration and visual loss who was successfully treated with interferon-alpha.. Interventional case report.. The patient was treated with interferon-alpha and had an improvement in his clinical signs, including his visual acuity, after 4 weeks of interferon therapy.. Interferon-alpha can be effective in the treatment of orbital infiltration secondary to Erdheim-Chester disease.

Topics: Exophthalmos; Granuloma; Histiocytosis, Non-Langerhans-Cell; Humans; Interferon-alpha; Magnetic Resonance Imaging; Male; Middle Aged; Orbital Diseases; Osteosclerosis; Radionuclide Imaging; Technetium Tc 99m Medronate; Visual Acuity; Xanthomatosis

The objective of this work was to study in more detail the human/murine SCID arthritis model with special emphasis on characteristic features initiated by rheumatoid arthritis (RA) synovial membrane (SM) as compared to appropriate control tissues. Small tissue samples from RA-SM, healthy lymph node, healthy SM, and granulomatous tissue of human origin were implanted into the left knee joint of mice with severe combined immunodeficiency (SCID), and the joints were analysed histologically after 7 days. In addition, a time course study, including non-invasive monitoring by serological parameters (human IgM, IgG, and IL-6) and Tc-99m-scintigraphy, was performed for up to 4 weeks on RA-SM recipients. All tissue implants induced transient exudative joint inflammation while RA-SM initiated a characteristic arthritis with pannus tissue of high cellular density, erosion, multinuclear giant cells, lining cell hyperplasia, fibroblast-like cell layers, chondroideal metaplasia, and fibrin deposits. Significantly elevated levels of human immunoglobulin and characteristic signs of chronic inflammation persisted for more than 4 weeks. We conclude that the hu/mu SCID arthritis with RA-SM implants comprises features of non-specific inflammation which is also transiently seen with control tissues but develops characteristic features of chronic RA-like synovitis thereafter.

Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Granuloma; Humans; Immunoglobulin G; Immunoglobulin M; Immunohistochemistry; Inflammation; Interleukin-6; Knee Joint; Lymph Nodes; Mice; Mice, SCID; Radionuclide Imaging; Synovial Membrane; Technetium Tc 99m Medronate; Time Factors; Transplantation Chimera

A case of a large plasma-cell granuloma of the left upper lobe in a 5-year-old girl is presented. Uptake of Tc-99m MDP by the soft tissue mass was demonstrated with bone imaging. Plasma cell granuloma should be included in the gamut of extraosseous uptake of bone-seeking radionuclide in the pediatric chest.

Topics: Child, Preschool; Female; Granuloma; Granuloma, Plasma Cell; Humans; Lung Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Adult; Animals; Bone and Bones; Calcinosis; Diphosphonates; False Positive Reactions; Female; Granuloma; Heparin; Humans; Injections, Subcutaneous; Male; Middle Aged; Rabbits; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate