technetium-tc-99m-medronate and Giant-Cell-Tumors

Soft tissue giant cell tumor (GCT) is rare. It usually involves the extremities. We report the case of a 37-year-old woman who was suspected of having mediastinal tumor on radiograph. Thoracic CT revealed the tumor had extensive calcification and invaded the adjacent vertebrae and spinal canal. It intensively accumulated Tc-methylene diphosphonate on bone scan. The tumor showed hypointensity on T1-weighted and mixed intensity on T2-weighted fat-saturated sagittal images. Finally, a soft tissue GCT was confirmed by pathology. The case cautions us soft tissue GCT should be in the differential diagnosis spectrum in a calcified posterior mediastinal mass with Tc-methylene diphosphonate accumulation.

Topics: Adult; Diagnosis, Differential; Female; Giant Cell Tumors; Humans; Mediastinal Neoplasms; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Giant Cell Tumors; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate

A case of giant cell tumor of bone is reported in which the blood flow study along with SPECT imaging improved the visualization and diagnosis of the abnormality.

Topics: Adult; Bone Neoplasms; Giant Cell Tumors; Humans; Male; Technetium Tc 99m Medronate; Tomography, Emission-Computed

Technetium-99m methylene diphosphonate bone scans were performed in 21 patients with giant cell tumors of bone. All tumors showed increased radiophosphate uptake, often more intense at the tumor periphery than in its center. However, radionuclide bone scanning often overestimated intraosseous tumor extent as a result of increased tracer uptake beyond true osseous tumor limits. In addition, it failed to detect soft-tissue tumor extension in nine patients. Therefore, scintigraphy is less useful than either computed or conventional tomography in planning surgical margins of giant cell tumors. Gallium-67 citrate scans obtained in seven patients showed slight uptake in four tumors and no uptake in three. Radiogallium imaging is thus of limited use in evaluation of suspected giant cell tumors of bone.

Topics: Adolescent; Adult; Angiography; Bone Neoplasms; Diphosphonates; Female; Gallium Radioisotopes; Giant Cell Tumors; Humans; Male; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

The scintigraphic appearance of giant cell tumor of bone in six patients is presented. Patients were studied by means of Tc-99m MDP bone scanning. On early blood pool and delayed imaging, markedly increased activity was noted, characteristically displaying a "ring" pattern that is readily discernible from patterns seen in bone cysts and nonosteogenic fibroma. The extent of the lesion, as judged by scintigraphic techniques, was roughly equal to estimates of extent by other radiographic modalities. Only one example of a different lesion mimicking giant cell tumor was encountered in over 100 cases of a variety of primary bone neoplasms reviewed. We conclude that giant cell tumor has a characteristic scintigraphic appearance.

Topics: Adult; Bone Neoplasms; Diphosphonates; Female; Giant Cell Tumors; Humans; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Although the "doughnut" sign in brain scintigraphy is a well known phenomenon, similar findings have recently been reported in bone scintigraphy in osseous and nonosseous lesions. A skeletal doughnut sign in bone scintigraphy caused by giant cell tumor of the proximal fibula is presented with a brief review of literature.

Topics: Adult; Bone Neoplasms; Diphosphonates; Female; Fibula; Giant Cell Tumors; Humans; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Fifty patients with bone primary tumors (multiple myeloma, osteogenic sarcoma, Ewing's sarcoma, giant cell tumor, and others) were studied gammagraphically after injecting 555 MBq of 99mTc-MDP. Eighty per cent of the cases were found in long bones, specially femur and tibia. These two bones were the preferent localization of osteosarcomas. Ewing's neoplasms were mostly diaphysial and osteoclastomas epiphysial.

Topics: Adolescent; Adult; Aged; Bone Neoplasms; Child; Female; Femur; Fibrosarcoma; Giant Cell Tumors; Humans; Male; Middle Aged; Multiple Myeloma; Osteosarcoma; Radionuclide Imaging; Sarcoma, Ewing; Technetium Tc 99m Medronate; Tibia

Topics: Adult; Bone Neoplasms; Diphosphonates; Etidronic Acid; Female; Gallium Radioisotopes; Giant Cell Tumors; Humans; Male; Organotechnetium Compounds; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate