technetium-tc-99m-medronate and Fever-of-Unknown-Origin

Topics: Adult; Bone Diseases; Female; Fever of Unknown Origin; Humans; Lung Abscess; Pleural Effusion; Radionuclide Imaging; Radiopharmaceuticals; Ribs; Technetium Tc 99m Medronate; Thorax

Topics: Aged; Back Pain; Ciprofloxacin; Discitis; Female; Fever of Unknown Origin; Humans; Lumbar Vertebrae; Organotechnetium Compounds; Radiopharmaceuticals; Sacrum; Staphylococcal Infections; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Cervical spinal Ewing's sarcomas are rare and cause problems in diagnosis. We present an unusual case of a primary extraosseous Ewing's sarcoma arising from the spinal cord. An 18-year-old woman with fever, headache and back pain lasting one month was admitted to the hospital. Whole body bone scintigraphy was performed with 1110 MBq technetium-99m methylenediphosphonate. Scintigraphy clearly showed abnormal technetium-99m methylenediphosphonate accumulation in the level of the 5th and 6th cervical vertebrae. Magnetic resonance imaging could also confirm this examination finding. After the scintigraphic study, the patient underwent surgery. Pathological diagnosis of the operation specimen was Ewing's sarcoma.

Topics: Adolescent; Back Pain; Cervical Vertebrae; Female; Fever of Unknown Origin; Headache; Humans; Neoplasms, Unknown Primary; Radionuclide Imaging; Radiopharmaceuticals; Sarcoma, Ewing; Spinal Neoplasms; Technetium Tc 99m Medronate

Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Diagnosis, Differential; Diagnostic Errors; Fever of Unknown Origin; Graft Rejection; Humans; Immunoglobulins; Radionuclide Imaging; Radiopharmaceuticals; Technetium; Technetium Tc 99m Medronate; Transplants

Topics: Adult; Anemia; Citrates; Citric Acid; Female; Fever of Unknown Origin; Gallium Radioisotopes; Humans; Multiple Myeloma; Proteinuria; Radionuclide Imaging; Technetium Tc 99m Medronate

Bone and gallium scintigraphy were performed as part of the diagnostic workup of a 21-yr-old woman who presented at our institution with a history of progressively worsening low back pain over a 1-wk period of time. The angiographic phase of the bone scan demonstrated a well-defined radionuclide blush within the pelvis just cephalad to the urinary bladder with persistent hyperemia noted in the blood-pool image. We attribute these findings to a uterine blush secondary to the pronounced uterine muscular hyperplasia, hyperemia, and edema that accompany pregnancy. Gallium scintigraphy demonstrated intense bilateral breast accumulation of the imaging agent in a typical doughnut pattern which is commonly found in the prelactating and lactating breast. Also demonstrated was apparent gallium accumulation in the placenta. This case is presented to emphasize the radionuclide findings that occur during pregnancy, particularly the incidental finding of radionuclide blush during the angiographic phase of a radionuclide scintigraphy which should alert the nuclear physician to the possibility of pregnancy in a woman of childbearing age.

Topics: Adult; Back Pain; Bone and Bones; Breast; Female; Fetus; Fever of Unknown Origin; Gallium Radioisotopes; Humans; Hyperemia; Placenta; Pregnancy; Pregnancy Trimester, Second; Radiation Dosage; Radionuclide Imaging; Technetium Tc 99m Medronate; Uterus

A 46-year-old woman was admitted to our hospital because of fever of unknown origin. Her fever continued with a daily rise to around 38 degrees C to 40 degrees C for more than six months, occasionally accompanied by polyarthralgia, erythematous rash and cervical lymphadenopathy. The erythrocyte sedimentation rate was 75 mm per hour and CRP was over 6+. The white-cell count was 15,100 with 21 percent band forms and the alpha 2-globulin was 18.8 percent of total protein. The tests for autoantibodies were negative. Clinical course and laboratory findings in this case were most compatible with adult Still's disease. A radionucleotide bone scan with 99mTc showed a greatly increased uptake of the radionucleotide at the large joints of the whole body, and a gallium scan also revealed accumulation of the radionucleotide at the bone marrow of the sternum. These findings were recognized during high fever and disappeared when the body temperature returned to normal. These examinations might be useful for investigating the active site of inflammation and for studying the pathogenesis of adult Still's disease.

Topics: Arthritis, Juvenile; Bone and Bones; Female; Fever of Unknown Origin; Gallium Radioisotopes; Humans; Joints; Middle Aged; Pain; Radionuclide Imaging; Technetium Tc 99m Medronate

A fast diagnosis (6h) of clinically latent pyonephrosis by combined use of 99mTc-MDP and 67Ga-citrate is reported. This technique combines the potential early detection of focal infectious processes by 67Ga and the "high-pulse" separation possibility of multiple isotopes. A brief prospective study (6 months) showed the interest of this technique: in six cases focal bone and/or joint infections were found three of which were absolutely latent clinically.

Topics: Adult; Diphosphonates; Female; Fever of Unknown Origin; Gallium Radioisotopes; Humans; Kidney Diseases; Prospective Studies; Proteus Infections; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Time Factors