technetium-tc-99m-medronate and Femoral-Neoplasms

Osteosarcoma is the most frequent primary malignancy of bone, and usually metastasizes to the lung and bones, while other sites are rare. In most reported cases, soft tissue metastasis of osteosarcoma is unusual, and only develops in the advanced stages of the disease, especially following multiple recurrences. We present a patient with recently diagnosed osteosarcoma of the right femur, showing abdominal wall metastasis diagnosed by technetium-99m-methylene diphosphonate (99m Tc-MDP) whole body bone scintigraphy and confirmed histologically. The present case highlights the importance of whole body imaging of patients with osteosarcoma for detecting unusual sites of metastasis, especially in soft tissue organs.

Topics: Abdominal Neoplasms; Abdominal Wall; Female; Femoral Neoplasms; Humans; Osteosarcoma; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Technetium Tc 99m Medronate; Young Adult

A 25-year-old patient with osteosarcoma of the right distal femur underwent a bone scintigraphy with Tc-99m methylene diphosphonate (MDP). Whole-body bone scan revealed extensive metastatic disease in the abdominal region. Abdominal computerized tomography confirmed the presence of ascites and calcified masses on the greater omentum and peritoneal surfaces. Here we describe a case of unusual metastatic pattern of an osteosarcoma showing extensive intraabdominal metastases without prominent lung involvement after intensive chemotherapy.

Topics: Abdominal Neoplasms; Adult; Female; Femoral Neoplasms; Humans; Lung Neoplasms; Osteosarcoma; Radionuclide Imaging; Radiopharmaceuticals; Rare Diseases; Technetium Tc 99m Medronate

Topics: Bone and Bones; Bone Neoplasms; Carcinoma, Squamous Cell; Femoral Neoplasms; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Osteolysis; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Aged; Biopsy; Carcinoma, Squamous Cell; Fatal Outcome; Femoral Neoplasms; Hip Prosthesis; Humans; Male; Neoplasms, Unknown Primary; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Thallium

Topics: Adult; Female; Femoral Neoplasms; Humans; Lung Neoplasms; Osteosarcoma; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

This paper aims to present the usefulness of the different diagnosis imaging methods (anatomical and functional) in the characterization of bone injury. Any data, however insignificant, is justified and should be specified. In this case, the discrepancy between the vascular and pool phases in the bone scintigraphy with 99mTc-MDP reveals revealed a lesion with an intense reaction secondary to the "foreign body effect", which is not necessarily malignant.

Topics: Adolescent; Diagnosis, Differential; Femoral Neoplasms; Foreign-Body Reaction; Humans; Magnetic Resonance Imaging; Osteoma, Osteoid; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

The regional blood flow of 30 distraction segments in 27 patients was measured during distraction osteogenesis. There were three groups of patients. Group A consisted of seven patients with high grade malignant tumors who received chemotherapy preoperatively and postoperatively. Group B consisted of eight patients with low grade malignant and aggressive benign tumors, who all were treated without chemotherapy. Group C (the control group) consisted of 12 patients with nontumoral conditions. Using quantitative technetium scintigraphy, the regional blood flow within the distracted segment and surrounding soft tissues was measured. The measured radioisotope count was expressed as the ratio of the distracted site to the control site (blood flow ratio). The blood flow ratio for all the cases averaged 1.70 +/- 0.70. Group A had a lower blood flow ratio, which was statistically significant in comparison with the other two groups. The external fixation index showed no significant difference in callus formation among these three groups. No correlation was found between the blood flow ratio and external fixation index. Chemotherapy decreases regional blood flow, but with distraction osteogenesis the regional blood flow can be kept within the normal range or higher. Distraction osteogenesis may overcome the effects of chemotherapy by increasing blood flow.

Topics: Adolescent; Adult; Aged; Bone Neoplasms; Child; Female; Femoral Neoplasms; Humans; Leg; Male; Middle Aged; Osteogenesis, Distraction; Radionuclide Imaging; Radiopharmaceuticals; Regional Blood Flow; Technetium Tc 99m Medronate; Tibia

A patient with initial complaints of leg pain and difficulty walking was found to have a large right tibial metastatic tumor and poorly differentiated adenocarcinoma of the lung. Findings from total-body bone scintigraphy include a large area of increased uptake in the proximal half of the right tibia with a photon-deficient area medially, and focal areas of uptake in a right rib, in the femoral neck and the left ileum. An irregular area of increased uptake in the left lung mass was shown by thoracic bone SPECT. This is an unusual case of a tibial metastasis as the first clinical presentation of bronchogenic adenocarcinoma.

Topics: Adenocarcinoma; Aged; Bone Neoplasms; Femoral Neoplasms; Femur Neck; Humans; Ileal Neoplasms; Ileum; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Radiopharmaceuticals; Ribs; Technetium Tc 99m Medronate; Tibia; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Whole-Body Counting

Topics: Aged; Bone Neoplasms; Breast Neoplasms; Female; Femoral Neoplasms; Humans; Humerus; Lymphatic Metastasis; Radionuclide Imaging; Radiopharmaceuticals; Skull Neoplasms; Technetium Tc 99m Medronate; Technetium Tc 99m Sestamibi

Topics: Adult; Femoral Neoplasms; Humans; Male; Osteosarcoma, Juxtacortical; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Adult; Diagnosis, Differential; Female; Femoral Neoplasms; Gallium Radioisotopes; Humans; Lymphoma, Large B-Cell, Diffuse; Radionuclide Imaging; Technetium Tc 99m Medronate

The complete removal of a lesion which resembles, or is covered by adjacent tissue may be difficult. Therefore, the capacity of certain lesions to specifically concentrate a radiopharmaceutical has been used to orient progress during surgery. Usually, the measurements of radioactivity in the operative field are carried out by means of small, handy radiation-detecting probes which can be sterilized. "Intra-operative nuclear medicine" or "radionuclide-guided surgery" has steadily gained in importance. However, this technique is not being taught. Our study, based on radionuclide-guided surgery of 175 orthopaedic patients suspected of having osteoid osteoma, is well suited to teach the particularities of intra-operative radiation detection, as well as the collaboration between the nuclear physician and the surgeon in the operating theatre.

Topics: Adult; Bone Neoplasms; Femoral Neoplasms; Humans; Intraoperative Care; Lumbar Vertebrae; Osteoma, Osteoid; Radiation Protection; Radionuclide Imaging; Spinal Neoplasms; Technetium Tc 99m Medronate; Tibia

Topics: Aged; Breast Neoplasms; Diagnosis, Differential; Female; Femoral Neoplasms; Humans; Neurilemmoma; Peripheral Nervous System Neoplasms; Radionuclide Imaging; Sciatic Nerve; Technetium Tc 99m Medronate

Topics: Adolescent; Bone Neoplasms; Femoral Neoplasms; Humans; Male; Radiography; Radionuclide Imaging; Sarcoma, Ewing; Skull Neoplasms; Spinal Neoplasms; Technetium Tc 99m Medronate

We describe a simple bone cyst in a patient who had an osteoblastic lesion which had been discovered 1 1/2 years earlier. Curettage and drilling proved effective treatment. We suggest that increased regional blood flow, in association with bone formation, produces a hydrodynamic disorder followed by venous obstruction leading to the formation of a bone cyst.

Topics: Biopsy; Bone Cysts; Bone Screws; Child; Curettage; Female; Femoral Neoplasms; Femur; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Osteoblastoma; Regional Blood Flow; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

A 17-year-old girl had a desmoplastic fibroma of the distal femur. This rare tumor is managed by surgery alone and requires a marginal to wide resection because of its high risk of local recurrence. Had the tumor invaded into the epiphysis and marginal resection, it would have resulted in loss of articular femoral condyle. It was treated by en bloc proximal resection with distal intralesional curettage and anatomic specific allograft femoral replacement. There was no recurrence of the tumor three years after surgery, and function was excellent.

Topics: Adolescent; Bone Transplantation; Female; Femoral Neoplasms; Fibroma, Desmoplastic; Humans; Magnetic Resonance Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Transplantation, Homologous

A patient with hyperparathyroidism secondary to chronic renal failure had multiple bony lesions with increased activity on both immediate static as well as delayed scintiphotos. One lesion in the distal femur was also exceptionally hot on the flow phase. Plain radiographs demonstrated lytic lesions with sclerotic margins and a narrow zone of transition. Open biopsy revealed histology consistent with brown tumor (osteoclastoma).

Topics: Acetabulum; Adult; Bone Neoplasms; Female; Femoral Neoplasms; Giant Cell Tumor of Bone; Humans; Hyperparathyroidism, Secondary; Kidney Failure, Chronic; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate

To evaluate previously described radiologic prognostic factors in extremity osteosarcoma.. In 47 pediatric patients, available images were evaluated for seven prognostic factors at diagnosis and seven additional factors after preoperative chemotherapy. These factors were correlated with histopathologic response and clinical outcome. The association of histopathologic response and outcome was also evaluated.. Metastases at presentation and a > 20-cm-diameter soft-tissue mass were predictive of a poor outcome but occurred in few patients. Factors most predictive of < 90% tumor necrosis after chemotherapy included an increase or no change in soft-tissue mass size and increased bone destruction. Although a significant relationship (P < .05) was found between histopathologic response and outcome, no factors predictive of histopathologic response were also predictive of outcome. The accuracy of pathologic response in predicting outcome was 66%.. Radiologic studies are of only limited use in predicting which patients with extremity osteosarcoma will have a poor response to chemotherapy or a poor outcome, and are not useful in predicting a good response or outcome.

Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Preschool; Diagnostic Imaging; Female; Femoral Neoplasms; Follow-Up Studies; Humans; Humerus; Magnetic Resonance Imaging; Male; Osteosarcoma; Prognosis; Salvage Therapy; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Tibia; Tomography, X-Ray Computed

A 3 1/2-year-old boy had thigh pain and a leg mass. Bone scanning demonstrated intense uptake within the involved femur, but no uptake within the soft tissues or evidence of metastatic spread. Radiographs and CT scanning showed a large soft tissue mass and periosteal reaction suggestive of Ewing's sarcoma. Following chemotherapy, the patient had an apparently good clinical response. However, bone scanning showed uptake that was more intense and extensive than it was before therapy. Plain films and CT showed that the uptake was evidence of soft tissue calcification and that the mass had shrunk. This is an unusual example of the flare response to therapy because the apparent progression of the disease on bone scanning was caused by extraskeletal uptake.

Topics: Antineoplastic Combined Chemotherapy Protocols; Calcinosis; Child, Preschool; Femoral Neoplasms; Humans; Male; Radionuclide Imaging; Sarcoma, Ewing; Technetium Tc 99m Medronate

Topics: Adult; Female; Femoral Neoplasms; Femur; Humans; Knee Joint; Osteoma, Osteoid; Osteosarcoma; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate

Tc-99m MDP bone scintigraphy is widely used for initial staging and subsequent follow-up of patients with osteosarcoma. Two unusual cases are presented here, one with diffuse pleural metastases and one with diffuse peritoneal metastases. In one case, an abnormal bone scan was the first indication of metastatic disease. Both the metastatic pattern of osteosarcoma and the indications for bone scintigraphy are reviewed.

Topics: Adolescent; Adult; Femoral Neoplasms; Humans; Male; Osteosarcoma; Peritoneal Neoplasms; Pleural Neoplasms; Radionuclide Imaging; Technetium Tc 99m Medronate

Extraosseous soft tissue metastases from osteosarcoma occasionally accumulate Tc-99m MDP. The authors present a case of osteogenic sarcoma of the femur with a pulmonary metastasis detected by bone imaging with radiographic correlation including CT and magnetic resonance imaging. The implication of the detection of osseous and extraosseous metastasis in these patients by bone imaging is discussed. The changing role of bone imaging in the initial workup and follow-up of patients with osteogenic sarcoma is reviewed in light of the change in course and prognosis of the disease as a result of recent advances in adjuvant chemotherapy.

Topics: Adult; Femoral Neoplasms; Humans; Lung Neoplasms; Male; Osteosarcoma; Radionuclide Imaging; Technetium Tc 99m Medronate

The soft tissue uptake of 99mTc-hydroxymethylene diphosphonate (99mTc-HMDP) due to subcutaneous injections of heparin calcium is reported in two patients with osteosarcoma. This uptake occurs in an unusual site, i.e. the shoulders and the anterior and posterior compartments of the upper arms.

Topics: Adolescent; Arm; Femoral Neoplasms; Heparin; Humans; Injections, Subcutaneous; Male; Osteosarcoma; Radionuclide Imaging; Technetium Tc 99m Medronate

Accumulation of Tc-99m MDP in soft tissue malignancies occurs frequently. When tumor overlaps adjacent bone structures, the bone margins can be indiscernible on a regular bone scan. Additional views should be taken to differentiate bone from tumor, however, separation is sometimes difficult and not always successful. This report presents a patient in whom accumulation of Tc-99m MDP in a liposarcoma of the thigh disappeared on a 24 hour scan and bone margins were seen clearly. A possible mechanism for this phenomenon and its utility are discussed.

Topics: Adult; Female; Femoral Neoplasms; Humans; Liposarcoma; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium Tc 99m Medronate; Thigh; Time Factors

Alpha-aminoisobutyric acid (AIB), a synthetic, nonmetabolized amino acid which is rapidly transported into viable cells by the A-type or alanine-preferring amino acid transport system, has been labeled with the short-lived, positron-emitting radionuclide carbon-11. Carbon-11 labeled AIB is currently being evaluated as a tumor imaging agent for in vivo amino acid transport studies in patients with cancer. In this study, C-11 AIB was used to image two patients with malignant fibrous histiocytoma (MFH), a pleomorphic sarcoma. Following intravenous administration of C-11 AIB, tumors in the distal femur of one patient and in the anterior chest wall of another patient were well visualized using high energy gamma scintigraphy. Since therapy may alter the accumulation of amino acids in tumor tissue, studies using C-11 AIB in patients with MFH before and after chemotherapy are in progress.

Topics: Adult; Aminoisobutyric Acids; Carbon Radioisotopes; Female; Femoral Neoplasms; Gallium Radioisotopes; Histiocytoma, Benign Fibrous; Humans; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate; Thoracic Neoplasms

Topics: Aged; Diagnosis, Differential; Femoral Neoplasms; Hip Prosthesis; Humans; Lymphoma, Non-Hodgkin; Male; Postoperative Complications; Prosthesis Failure; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Diagnosis, Differential; Female; Femoral Neoplasms; Humans; Middle Aged; Neurilemmoma; Neurofibroma; Radionuclide Imaging; Technetium Tc 99m Medronate

A 64-year-old man with right knee pain had uptake of Tc-99m MDP in the area as well as in the greater trochanter. Both sites were shown to contain osteogenic sarcoma. There was resection of the bone. Eight months later, radiogallium uptake was avid in the nearby soft tissue, indicating tumor spread.

Topics: Femoral Neoplasms; Humans; Male; Middle Aged; Osteosarcoma; Radionuclide Imaging; Technetium Tc 99m Medronate

We have excised six cases of osteoid osteoma in children, by using intra-operative accurate radioactive localization. The value of this technique is considerable and allows a better localization of the lesion. Exact detection and elective excision are the two advantages of this technique. We are reporting these case and describing the equipment being used.

Topics: Adolescent; Adult; Carpal Bones; Child; Female; Femoral Neoplasms; Femur Neck; Humans; Intraoperative Period; Male; Osteoma, Osteoid; Radionuclide Imaging; Technetium Tc 99m Medronate; Tibia

The high sensitivity of bone scintigraphy in detecting osteoid osteoma throughout the skeleton has been documented. Recently, radioactive surgical specimens of osteoid osteomas were studied with microradiography, autoradiography, and well-counter scintimetry and were shown to concentrate most of the radionuclide within the nidus of the lesion. These techniques also proved helpful to surgeons in achieving cure with conservative bone excision. We present two cases of osteoid osteoma, one of them recurrent, in which the patients were injected with bone-seeking agent just prior to surgery. The excised specimens were immediately imaged and the entire nidus was seen, confirming the complete removal of the lesion. This simple and rapid procedure is suggested whenever difficulty is anticipated in removal of an osteoid osteoma.

Topics: Adolescent; Child; Diphosphonates; Femoral Neoplasms; Femur Neck; Humans; Intraoperative Period; Male; Osteoma, Osteoid; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

A clinically and radiographically unsuspected ossified renal metastasis from a primary osteogenic sarcoma was identified by computed tomography (CT) and radionuclide bone scan. These imaging modalities play an important adjunctive role in the evaluation and follow-up of patients with primary osteogenic sarcoma.

Topics: Adolescent; Diphosphonates; Female; Femoral Neoplasms; Humans; Kidney Neoplasms; Osteosarcoma; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Adolescent; Diphosphonates; Femoral Neoplasms; Femur Head; Humans; Male; Osteoma, Osteoid; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

The precise localisation of an osteoid osteoma was revealed during operation after an injection of technetium 99m in children. The technique, using a Pitman 235N counter is described.

Topics: Child; Diphosphonates; Female; Femoral Neoplasms; Femur Neck; Humans; Intraoperative Period; Male; Osteoma, Osteoid; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Adolescent; Adult; Diphosphonates; Femoral Neoplasms; Humans; Male; Osteoma, Osteoid; Technetium; Technetium Tc 99m Medronate; Tomography, X-Ray

The double-density sign, seen on radionuclide bone scans, is described for diagnosing osteoid osteomas and for localizing the nidus. Its use in differentiating the nidus of an osteoid osteoma from osteomyelitis is also described. The utility of computed tomography in localization of the nidus is also illustrated. The double-density sign was helpful in diagnosing seven cases of surgically confirmed osteoid osteoma.

Topics: Adolescent; Adult; Bone Neoplasms; Diphosphonates; Female; Femoral Neoplasms; Humans; Humerus; Male; Osteoma, Osteoid; Spinal Neoplasms; Technetium; Technetium Tc 99m Medronate; Tomography, Emission-Computed

Sequential gallium scans were performed in 37 patients with newly diagnosed osteogenic sarcoma. High gallium uptake was found more often in males in the 10 to 19 age group and in femoral lesions. High uptake was also seen in patients who had predominantly osteoblastic or mixed changes on radiographs and in those who had a soft tissue mass. Following chemotherapy, significant decrease of tumor to nontumor ratio occurred in the patients who responded to treatment as shown by a Grade III or IV response on histologic examinations at the time of en bloc resection. It is concluded that semiquantitative gallium scintigraphy is useful in monitoring therapeutic response in patients with osteogenic sarcoma.

Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Diphosphonates; Female; Femoral Neoplasms; Gallium Radioisotopes; Humans; Male; Osteosarcoma; Prognosis; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Time Factors

Two cases of benign cortical irregularity of the distal femur ( BCIDF ), which radiologically simulate malignancy, are presented. The use of bone scintigraphy in differentiating this entity from malignancy is described.

Topics: Adolescent; Biopsy; Child; Diagnosis, Differential; Diphosphonates; Femoral Neoplasms; Femur; Humans; Knee Joint; Male; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Skeletal scintigraphy of a distal femoral osteosarcoma revealed a band of soft-tissue uptake in the medial thigh extending to the groin, which corresponded to direct perivascular tumor extension.

Topics: Adult; Diphosphonates; Femoral Neoplasms; Humans; Male; Osteosarcoma; Radionuclide Imaging; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Medronate; Thigh

Topics: Child; Diphosphonates; Female; Femoral Neoplasms; Femur Neck; Gallium Radioisotopes; Humans; Radionuclide Imaging; Rhabdomyosarcoma; Technetium; Technetium Tc 99m Medronate

Topics: Adult; Diphosphonates; Female; Femoral Neoplasms; Humans; Intraoperative Period; Osteoma, Osteoid; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

The nonspecific symptoms and radiographic findings associated with osteoid osteoma in the proximal femur mimic inflammatory conditions and delay diagnosis. A review of four cases showed high resolution computerized axial tomography in conjunction with a radioisotope bone scan best demarcated the location and size of the lesion. The combination of careful preoperative localization and intraoperative use of a radiation probe made adequate resection possible while limiting the amount of bone excised. This technique eliminated the need for internal fixation and reduced the duration of the recovery period.

Topics: Adult; Child; Diphosphonates; Female; Femoral Neoplasms; Humans; Intraoperative Care; Male; Osteoma, Osteoid; Technetium; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Bone scintigrams of 25 aneurysmal bone cysts showed abnormal activity in every case. In 22 cases, the activity was correlated with the true pathologic extent of the lesions; only three exhibited a false-positive extended pattern of uptake beyond the true tumor margins. Sixteen scintigrams (64%) revealed increased uptake, chiefly around the periphery of the lesions, with less activity in their centers. This feature could not be explained simply by the cystic nature of the lesions, since aneurysmal bone cysts may contain considerable fibrous tissue septa containing trabeculae of reactive new bone. However, there was no correlation between any specific anatomic or histologic pattern and the intensity and pattern of abnormal scintigraphic activity.

Topics: Adolescent; Adult; Bone Cysts; Child; Child, Preschool; Diphosphates; Diphosphonates; Female; Femoral Neoplasms; Fibula; Humans; Male; Radionuclide Imaging; Scapula; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Pyrophosphate; Ulna

An intratibially transplantable osteogenic sarcoma in rats, that regularly disseminates osteogenic metastases in the lung, is described. The tumor take rates exceeded 90% 30 days after transplantation. Pulmonary metastases were diagnosed in about 99% of the animals, while metastases in the kidneys (14%), lymph nodes (13%) and liver (3%) occurred less frequently. The mean survival time of untreated animals varied between 36 and 48 days, depending on the age at transplantation. Histologic and scintigraphic findings are reported.

Topics: Animals; Bone Neoplasms; Cell Line; Diphosphonates; Female; Femoral Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Neoplasm Transplantation; Osteosarcoma; Radiography; Radionuclide Imaging; Rats; Rats, Inbred Strains; Technetium; Technetium Tc 99m Medronate; Tibia; Time Factors

Topics: Child; Diphosphonates; Female; Femoral Neoplasms; Humans; Osteosarcoma; Pleural Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Advances in radionuclide imaging have facilitated the accurate diagnosis and surgical excision of osteoid osteoma. While radionuclide imaging has been inconsistent in the diagnosis of certain problems, its accuracy in the diagnosis of osteoid osteoma has been frequently stressed. To date, no case of a negative bone scan in the presence of a histologically proven osteoid osteoma has been reported. The present case report emphasizes that a negative bone scan does not preclude the diagnosis of osteoid osteoma. Clinical suspicion remains the most sensitive indicator of this lesion.

Topics: Child; Diphosphonates; Femoral Neoplasms; Humans; Male; Osteoma, Osteoid; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Aged; Bone Neoplasms; Diphosphonates; Female; Femoral Neoplasms; Fibrosarcoma; Humans; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Tibia

99mTc-methylene diphosphonate (MDP) bone scintigraphy demonstrated localization in an intracranial metastasis of osteogenic sarcoma. This unusual case suggests that bone scintigraphy may have diagnostic value in the early diagnosis of metastatic ossifying lesions.

Topics: Adult; Brain Neoplasms; Diphosphonates; Femoral Neoplasms; Humans; Male; Occipital Lobe; Osteosarcoma; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

The pathologic specimens of 18 osteosarcomas of long bones were examined to correlate histologic abnormalities with abnormalities seen on preoperative 99mTc pyrophosphate or methylene diphosphonate bone scans. Seven scans accurately represented the extent of the tumor. Eleven scans disclosed increased activity extending beyond the radiographic abnormalities. In eight of these, there was no occult tumor extension and in the other three, the scan activity did not accurately portray the skip metastases that were present. Therefore, these 11 scans demonstrated the falsely extended pattern of uptake beyond the true limits of the tumors. Pathologic slides were available for 10 of the 11 areas of bone that exhibited extended uptake. In two instances, there was no pathologic abnormality. In the other eight cases we found marrow hyperemia, medullary reactive bone, or periosteal new bone. This is the first description of these histologic abnormalities of medullary bone in areas of extended uptake on radionuclide bone scans.

Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Diphosphates; Diphosphonates; Female; Femoral Neoplasms; Humans; Male; Osteosarcoma; Radionuclide Imaging; Retrospective Studies; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Pyrophosphate

Topics: Adolescent; Bone Neoplasms; Child; Diagnosis, Differential; Diphosphonates; Female; Femoral Neoplasms; Fibroma; Humans; Joint Diseases; Knee Joint; Male; Periosteum; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Scintigraphy in 3 patients with chondroblastoma showed that the tumors were hyperemic and avidly accumulated the radionuclide. These changes were also present in adjacent normal bone, but to a lesser degree. This suggest that radionuclide uptake in chondroblastoma is a function of the blood supply to the tumor rather than primary matrix extraction.

Topics: Bone Neoplasms; Child; Chondroblastoma; Diphosphonates; Femoral Neoplasms; Humans; Humerus; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Tibia; Time Factors