technetium-tc-99m-medronate and Erdheim-Chester-Disease

A 56-year-old woman with history of cosmetic buttock augmentation via mineral oil injection 20+ years ago presented with extensive abdominopelvic skin induration and hypercalcemia. The 99mTc-MDP bone scintigraphy performed for hypercalcemia revealed marked heterogeneous radiotracer activity partially obscuring the skeleton. Subsequent SPECT/CT demonstrated that the radiotracer activity was associated with exclusively subcutaneous calcification, the extent of which far exceeded the originally augmented gluteal regions. After extensive workup including tissue biopsy, the final diagnosis was subcutaneous calcification and hypercalcemia secondary to cosmetic injection-related sclerosing lipogranulomatosis, which is a very rare complication of cosmetic augmentation.

Topics: Calcinosis; Erdheim-Chester Disease; Female; Humans; Middle Aged; Radiopharmaceuticals; Single Photon Emission Computed Tomography Computed Tomography; Technetium Tc 99m Medronate

A 62-year-old man presented with diabetes insipidus, pulmonary fibrosis, right atrial tumor and bilateral knee osteoarthritis with cystic lesions of distal femur and proximal tibia. Scintigraphy and histological examination of right femur bone biopsy revealed changes characterized for Paget's disease. Re-evaluation of the computer tomography (CT) scans and histological samples revealed diffuse infiltrates of foamy histiocytes in the bone marrow what was consistent with Erdheim-Chester disease. Positron emission tomography/computed tomography (PET/CT) was performed to access the activity and extent of disease.

Topics: Bone Marrow; Erdheim-Chester Disease; Fluorodeoxyglucose F18; Histiocytes; Humans; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Aged; Biopsy; Contrast Media; Diagnosis, Differential; Erdheim-Chester Disease; Humans; Humeral Fractures; Male; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed; Tomography, X-Ray Computed

Topics: Adult; Bone and Bones; Erdheim-Chester Disease; Humans; Male; Positron-Emission Tomography; Radionuclide Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Bone and Bones; Erdheim-Chester Disease; Fatal Outcome; Hepatomegaly; Humans; Male; Middle Aged; Osteosclerosis; Radionuclide Imaging; Splenomegaly; Technetium Tc 99m Medronate

Topics: Child; Citrates; Elbow Joint; Erdheim-Chester Disease; Facial Bones; Female; Gallium; Humans; Knee Joint; Osteosclerosis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Erdheim-Chester's disease is a form of histiocytic granulomatosis afflicting the skeletal system and various inner organs. Apart from incidental findings of involvement of various structures and tissues, a complete diagnostic workup to evaluate afflicted bodily parts is not known. The authors we present several specific isotope-diagnostic techniques of a case to support the identification of this rare multisystem infiltrative disease.

Topics: Bone and Bones; Coronary Disease; Erdheim-Chester Disease; Heart; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Orbital Diseases; Organophosphorus Compounds; Organotechnetium Compounds; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Whole Body Imaging

Topics: Erdheim-Chester Disease; Humans; Leg Bones; Male; Middle Aged; Pain; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Arthralgia; Bone Diseases, Metabolic; Bone Neoplasms; Diagnosis, Differential; Erdheim-Chester Disease; Female; Hip Joint; Humans; Middle Aged; Muscle Neoplasms; Osteitis Deformans; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate