technetium-tc-99m-medronate and Dermatomyositis

Two children with juvenile dermatomyositis and extensive, debilitating soft tissue calcifications are described. Whole-body bone scans with Tc-99m MDP were performed in both cases before and during specific treatment for the calcinosis. Baseline studies showed marked tracer localization in the soft tissues and provided an objective baseline assessment of the extent of the soft tissue calcifications. Follow-up studies showed gradual clearance of the extraskeletal uptake and were useful in monitoring the therapeutic response. These cases show that skeletal scintigraphy can function as a useful auxiliary tool to evaluate calcinosis in children with juvenile dermatomyositis.

Topics: Bone and Bones; Calcinosis; Child, Preschool; Dermatomyositis; Female; Follow-Up Studies; Humans; Male; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Time Factors

Topics: Adult; Bone and Bones; Calcinosis; Dermatomyositis; Female; Humans; Pelvic Bones; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Whole-Body Counting

The authors present a case of extensive soft-tissue radioactivity visualized on both 99mTc-MDP and 201Tl-chloride scintigrams in a patient with dermatomyositis and colon cancer. Incidentally, diffuse and intense uptake of 99mTc-MDP was observed in the shoulder girdles, anterior chest wall, psoas muscles, both proximal thighs and right lower limb, corresponding to the sites of symptomatic muscles, even though skin lesions were limited and no calcification was detected on radiographs. Moreover, 201Tl-chloride was also intensely accumulated in nearly the same sites as the symptomatic muscles as shown on the 99mTc-MDP bone scintigrams. Whole-body scintigraphy with 99mTc-MDP and 201Tl-chloride is a useful tool to detect occult muscle lesions with dystrophic calcification and hyperemia in dermatomyositis.

Topics: Calcinosis; Colonic Neoplasms; Dermatomyositis; Humans; Male; Middle Aged; Muscles; Radionuclide Imaging; Technetium Tc 99m Medronate; Thallium; Thallium Radioisotopes

Topics: Adult; Bone and Bones; Dermatomyositis; Diphosphonates; Female; Humans; Kidney; Muscles; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Calcinosis; Child; Dermatomyositis; Diphosphonates; Humans; Male; Prognosis; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate