technetium-tc-99m-medronate and Carcinoma--Adenoid-Cystic

Topics: Aged; Bone Neoplasms; Carcinoma, Adenoid Cystic; Humans; Male; Maxillary Neoplasms; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Salivary Gland Neoplasms; Technetium Tc 99m Medronate

Skeletal scintigraphy, a sensitive diagnostic tool used to detect changes in bone, is helpful for evaluating bone invasion by oral cancer. However, the exact sites of accumulation of 99mTc-phosphate compounds in the mandible have not yet been fully elucidated. The aim of this study was to determine the localization of 99mTc-methylene diphosphonate (MDP) in the areas of mandible that have been invaded by cancer.. Seven patients with oral cancer (lower gingiva, 4; tongue, 2; floor of the mouth, 1) who underwent surgical treatment with mandibular bone resection were included in the study. Autoradiography and contact macroradiography were used for evaluation of 99mTc-MDP accumulation.. Radioactivity reflecting accumulation of 99mTc-MDP was documented encircling the portion of the mandible with cancerous invasion, suggesting that 99mTc-MDP accumulated in immature bone. High uptake also was found in the periosteal reactive bone around the cortical bone.. The amount of increased 99mTc-MDP circumscribing carcinoma invasion varies among cases. Additionally, uptake may not correspond directly with the amount of the carcinoma invasion; that seen in periosteal bone could be attributed mistakenly to bone invasion in planar scintigraphy.

Topics: Aged; Alveolar Process; Autoradiography; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Female; Gingival Neoplasms; Humans; Male; Mandibular Neoplasms; Middle Aged; Mouth Floor; Neoplasm Invasiveness; Radionuclide Imaging; Technetium Tc 99m Medronate; Tongue Neoplasms

The decision of whether to perform continuity-sparing or resecting surgery of the jaw in cases of malignant oral tumors is often difficult.. To aid in this decision, bone scintigraphy was evaluated retrospectively in 304 patients with a squamous cell carcinoma.. One hundred forty-five patients showed no accumulation of the radionuclide, and none of them had infiltration by tumor histologically.. It was concluded that a bone-sparing resection of tumors close to the jaw may be justified when there is a negative bone scan.

Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Adenoid Cystic; Carcinoma, Squamous Cell; Cheek; Child; Diphosphonates; False Negative Reactions; Female; Humans; Jaw Neoplasms; Lip Neoplasms; Male; Middle Aged; Mouth Floor; Mouth Neoplasms; Organotechnetium Compounds; Patient Care Planning; Predictive Value of Tests; Radiography; Radionuclide Imaging; Retrospective Studies; Technetium Tc 99m Medronate; Tongue Neoplasms