technetium-tc-99m-medronate and Calcinosis

Metastatic pulmonary calcification (MPC) is rarely reported in primary hyperparathyroidism, especially MPC develops quickly. We report such a case here with a literature review.. A 41-year-old woman presented with cough and dyspnea. Data from clinical, radiological, pathological, technetium (. Rapidly progressive MPC tends to be misdiagnosed as many primary pulmonary diseases.

Topics: Adenoma; Adult; Calcinosis; Disease Progression; Female; Humans; Hyperparathyroidism, Primary; Image-Guided Biopsy; Lung Diseases; Parathyroid Neoplasms; Parathyroidectomy; Positron-Emission Tomography; Radiopharmaceuticals; Technetium Tc 99m Medronate; Technetium Tc 99m Sestamibi; Tomography, X-Ray Computed; Treatment Outcome

We report a case of a 39-year-old female with active systemic lupus erythematosus who complained of lethargy and weakness with a moderate renal impairment. Hypercalcemia was confirmed by laboratory examination. Her X-ray revealed significant ectopic calcinosis in subcutaneous tissue of bilateral hands, and Tc-99(m) methylene diphosphonate bone scan revealed a remarkably intense uptake of bilateral lungs. She had no evidence suggestive of other diseases related to hypercalcemia such as hyperparathyroidism and malignancy. She had abnormally high serum parathyroid hormone-related protein (PTHrP) which fell to normal after treatment. Glucocorticoid, cyclophosphamide plus calcitonin and etidronate were administered and the patient improved greatly. Literature review demonstrated that lupus-related hypercalcemia with ectopic calcinosis is a rare complication and increased PTHrP is probably one of the main mechanisms. Lung uptake in bone scan may be a special and reliable clue suggestive of hypercalcemia.

Topics: Adult; Biomarkers; Bone Density Conservation Agents; Calcinosis; Calcitonin; Cyclophosphamide; Drug Therapy, Combination; Etidronic Acid; Female; Glucocorticoids; Humans; Hypercalcemia; Immunosuppressive Agents; Lung; Lupus Erythematosus, Systemic; Parathyroid Hormone; Radiopharmaceuticals; Technetium Tc 99m Medronate; Treatment Outcome; Whole Body Imaging

In patients with renal bone disease skeletal and extra-skeletal abnormalities can be visualised using conventional bone scintigraphy. Some of these abnormalities are associated with characteristic scintigraphic appearances, which are reviewed in detail, and the possible mechanisms involved are discussed. Specific imaging with iodine 123 serum amyloid P component and iodine 131 beta 2-microglobulin is also discussed in the diagnosis of beta 2-microglobulin amyloidosis specific to patients on dialysis. In the light of available evidence, it appears that bone scintigraphy plays, so far, a limited role in the clinical evaluation of skeletal and extra-skeletal abnormalities in chronic renal failure. The potential role of bone scintigraphy in identifying patients with aluminium-related bone disease needs to be investigated further, and in this respect special attention must be given to the problem of high soft-tissue activity associated with impaired renal function. Timing haemodialysis sessions before scintigraphic imaging deserves wider recognition as it reduces high soft-tissue activity, thereby allowing bone uptake to be assessed more accurately. Specific imaging of amyloidosis resulting from beta 2-microglobulin deposition is a promising technique, but the relative value of the two proposed radiopharmaceuticals needs further clarification.

Topics: Amyloidosis; Calcinosis; Chronic Kidney Disease-Mineral and Bone Disorder; Etidronic Acid; Humans; Kidney Failure, Chronic; Organotechnetium Compounds; Radionuclide Imaging; Renal Dialysis; Technetium Tc 99m Medronate

Over the past 5 years, we have encountered 6 cases of diffuse pulmonary uptake of 99m-Tc bone-scanning agents (incidence, 0.04%). To assess the significance of this phenomenon, we reviewed all of the cases reported since 1974 (Including our series, a total of 32 cases). Three groups can be discerned, the first consisting of 24 patients without radiological calcifications in the lungs and with hypercalcemia of different origins (mostly hyperparathyroidism). Of the eight autopsies performed in this group, seven revealed extensive calcifications in alveolar walls and lung vessels; the other autopsy showed no calcification at all and only bronchopneumonic lesions. The second group consists of 6 patients in chronic dialysis. The last group consists of 2 patients having diffuse pulmonary alveolar microlithiasis with extensive radiologic calcifications. The mechanism of lung uptake of 99m-Tc bone-imaging agents is probably the same as that of bone uptake (chemisorption on hydroxyapatite crystals), although other uptake mechanisms have also been discussed. Bone scintigraphy can be useful in the detection of early pulmonary calcifications, which have been associated with impaired pulmonary function and, due to their size, are generally not detected by X-ray.

Topics: Adenoma; Adult; Aged; Bone Diseases; Calcinosis; Female; Humans; Hypercalcemia; Lung Diseases; Male; Middle Aged; Multiple Myeloma; Parathyroid Neoplasms; Radionuclide Imaging; Technetium Tc 99m Medronate; Vitamin D

Renal tumoural calcinosis is rare, but the incidence is rising with increasing life expectancy due to dialysis. Whole body skeletal scintigraphy with 99mTc- MDP is a sensitive method to detect sites of osseous involvement. We share an interesting image of the bone scan, in a patient with extensive renal tumoural calcinosis.

Topics: Calcinosis; Humans; Radionuclide Imaging; Radiopharmaceuticals; Renal Dialysis; Technetium Tc 99m Medronate

A 56-year-old woman with history of cosmetic buttock augmentation via mineral oil injection 20+ years ago presented with extensive abdominopelvic skin induration and hypercalcemia. The 99mTc-MDP bone scintigraphy performed for hypercalcemia revealed marked heterogeneous radiotracer activity partially obscuring the skeleton. Subsequent SPECT/CT demonstrated that the radiotracer activity was associated with exclusively subcutaneous calcification, the extent of which far exceeded the originally augmented gluteal regions. After extensive workup including tissue biopsy, the final diagnosis was subcutaneous calcification and hypercalcemia secondary to cosmetic injection-related sclerosing lipogranulomatosis, which is a very rare complication of cosmetic augmentation.

Topics: Calcinosis; Erdheim-Chester Disease; Female; Humans; Middle Aged; Radiopharmaceuticals; Single Photon Emission Computed Tomography Computed Tomography; Technetium Tc 99m Medronate

A 59-year-old woman presented with fever for 2 weeks. The patient had end-stage renal disease and was undergoing dialysis therapy for 10 years. Plain radiographs revealed extensive calcification in the subcutaneous tissues of the shoulders, thighs, and hips. In this case, TC-MDP bone scan detected all sites of subcutaneous metastatic calcification in one sweep. Ga-citrate scintigraphy was also performed and showed similar uptake at the same locations as those revealed by the bone scan, suggesting the existence of an inflammatory process at the sites of metastatic calcification.

Topics: Calcinosis; Female; Gallium Radioisotopes; Humans; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Subcutaneous Tissue; Technetium Tc 99m Medronate

Hypercalcemia is a severe complication in cases of vitamin D intoxication that can result in metastatic calcification. We herein report a female case with hypercalcemia due to eldecalcitol administration associated with the increased uptake of technetium-99m hydroxymethylene diphosphonate (

Topics: Bone Density Conservation Agents; Calcinosis; Female; Humans; Hypercalcemia; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Stomach Diseases; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Vitamin D

Metastatic calcification relates to abnormal calcification resulting from hypercalcaemia in otherwise normal tissues. Hypercalcaemia can occur secondary to chronic renal failure, hyperparathyroidism, hypervitaminosis D, and metastatic neoplasms. Specific symptoms are often lacking, but calcification may be a marker of disease severity and its chronicity. We present cases with different patterns of soft tissue calcification on Tc99m MDP bone scan.

Topics: Aged; Bone Neoplasms; Breast Neoplasms; Calcinosis; Carcinoma; Female; Humans; Hypercalcemia; Kidney Failure, Chronic; Lung; Male; Middle Aged; Neoplasm Metastasis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Thoracic Wall

Metastatic pulmonary calcification (MPC) is an uncommon entity resulting from abnormalities in calcium-phosphorus homoeostasis. Most cases reported in the literature are among patients with chronic kidney disease receiving haemodialysis. Primary hyperparathyroidism is a relatively common condition affecting calcium homoeostasis, in which MPC can rarely occur. We report the case of one such patient who presented with severe hypercalcaemia and features of interstitial lung disease. Radiographic imaging was normal and the diagnosis was clinched by diffuse pulmonary uptake in

Topics: Adult; Calcinosis; Dyspnea; Female; Humans; Hyperparathyroidism, Primary; Parathyroidectomy; Radionuclide Imaging; Technetium Tc 99m Medronate; Treatment Outcome; Vomiting

Intense activity was noted in the right middle abdomen on whole-body Tc-MDP bone scan images, which were obtained in a 78-year-old woman who had back pain. Further SPECT/CT images demonstrated that the intense activity was located in an elongated gallbladder. Partially calcified gallstone was also revealed on SPECT/CT images. Unexpectedly, the gallbladder activity was from the radioactive bile inside the gallbladder lumen, whereas the partially calcified gallstone was relatively photopenic.

Topics: Aged; Calcinosis; Female; Gallstones; Humans; Single Photon Emission Computed Tomography Computed Tomography; Technetium Tc 99m Medronate; Whole Body Imaging

A 41-year-old woman presented with cough and shortness of breath for 3 weeks. Chest x-ray and CT showed a large, partially calcified soft tissue mass adjacent to the right side of the heart. Whole-body bone was acquired to evaluate possible metastases, which showed abnormal accumulation of Tc-MDP in the right chest. Further SPECT/CT imaging that demonstrated intense Tc-MDP activity was mainly in the calcification portion of mass. Histopathological examination from biopsy specimen of the lesion was consistent with malignant teratoma.

Topics: Adult; Calcinosis; Female; Humans; Mediastinal Neoplasms; Multimodal Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Teratoma; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Topics: Calcinosis; Humans; Hypercalcemia; Male; Middle Aged; Paget Disease, Extramammary; Paraneoplastic Syndromes; Predictive Value of Tests; Radiopharmaceuticals; Technetium Tc 99m Medronate; Whole Body Imaging

Topics: Aged; Atherosclerosis; Calcinosis; Carotid Artery Diseases; Humans; Male; Osteoblasts; Osteogenesis; Radionuclide Imaging; Technetium Tc 99m Medronate

In previous work, we demonstrated the presence of hydroxyapetite (type II microcalcification), HAP, in triple negative MDA-MB-231 breast cancer cells. We used (18)F-NaF to detect these types of cancers in mouse models as the free fluorine, (18)F(-), binds to HAP similar to bone uptake. In this work, we investigate other bone targeting agents and techniques including (99m)Tc-MDP SPECT and Osteosense 750EX FMT imaging as alternatives for breast cancer diagnosis via targeting HAP within the tumor microenvironment.. Thirteen mice were injected subcutaneously in the right flank with 10(6) MDA-MB-231 cells. When the tumor size reached ~0.6 cm(3), mice (n=9) were injected with ~37 MBq of (99m)Tc-MDP intravenously and then imaged one hour later in a NanoSPECT/CT or injected intravenously with 4 nmol/g of Osetosense 750EX and imaged 24 hours later in an FMT (n=4). The imaging probe concentration in the tumor was compared to that of muscle. Following SPECT imaging, the tumors were harvested, sectioned into 10 μm slices, and underwent autoradiography or von Kossa staining to correlate (99m)Tc-MDP binding with HAP distribution within the tumor. The SPECT images were normalized to the injected dose and regions-of-interest (ROIs) were drawn around bone, tumor, and muscle to obtain the radiotracer concentration in these regions in units of percent injected dose per unit volume. ROIs were drawn around bone and tumor in the FMT images as no FMT signal was observed in normal muscle.. Uptake of (99m)Tc-MDP was observed in the bone and tumor with little or no uptake in the muscle with concentrations of 11.34±1.46 (mean±SD), 2.22±0.95, and 0.05±0.04%ID/cc, respectively. Uptake of Osteosense 750EX was also observed in the bone and tumor with concentrations of 0.35±0.07 (mean±SD) and 0.04±0.01picomoles, respectively. No FMT signal was observed in the normal muscle. There was no significant difference in the bone-to-tumor ratio between the two modalities (5.1±2.3 for SPECT and 8.8±2.2 for FMT) indicating that there is little difference in tumor uptake between these two agents.. This study provides evidence of the accessibility of HAP within the breast tumor microenvironment as an in vivo imaging target for bone-seeking agents. SPECT imaging using (99m)Tc-MDP can be rapidly translated to the clinic. FMT imaging using Osteosense 750EX is not currently approved for clinical use and is limited to animal research.

Topics: Animals; Bone and Bones; Breast Neoplasms; Calcinosis; Cell Line, Tumor; Humans; Mice; Optical Imaging; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

A 56-year-old man presented with swelling bilateral shoulders for 2 months. Plain radiograph and CT demonstrated symmetric masses with plaque calcification in bilateral shoulders. A Tc-MDP bone scintigraphy revealed intense radiotracer uptake not only in the masses of bilateral shoulders but also in the masses of the right buttock and the left thigh. The masses in bilateral shoulders were resected, and the pathological examination confirmed the ectopic calcification. This is a rare case of multiple ectopic calcification in subcutaneous tissues in a patient with chronic renal failure.

Topics: Calcinosis; Humans; Kidney Failure, Chronic; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Subcutaneous Tissue; Technetium Tc 99m Medronate

A 55-year-old man was a hepatocellular carcinoma patient, diagnosed by sonography and a biopsy. Because of his musculoskeletal tenderness, a bone scan was performed to exclude skeletal metastasis. A subsequent F-FDG PET/CT scan revealed that the unilateral abnormal uptake seen on the bone scan was actually a mineralized tendon. A mineralized tendon is easily detectable using Tc-MDP; therefore, it is imperative to differentiate between bone lesions and mineralized tendons. In addition, few studies have reported F-FDG uptake in a calcified tendon.

Topics: Bone Neoplasms; Calcinosis; Diagnosis, Differential; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Technetium Tc 99m Medronate; Tendons; Tomography, X-Ray Computed

Topics: Bone and Bones; Calcinosis; Humans; Male; Middle Aged; Parathyroid Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Biopsy; Bone Density Conservation Agents; Bone Neoplasms; Calcinosis; Calcium; Diagnosis, Differential; Diphosphonates; Drug Therapy, Combination; Edema; Humans; Humerus; Imidazoles; Male; Middle Aged; Multimodal Imaging; Osteolysis, Essential; Positron-Emission Tomography; Radiopharmaceuticals; Sarcoma, Synovial; Scapula; Shoulder Joint; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Vitamin D; Zoledronic Acid

Sphenoidal sinus carcinoma is a rare cause of hypercalcemia of malignancy. We report on a 37-year-old male with sphenoidal sinus carcinoma with intracranial extension who developed hypercalcemia of malignancy with progressing disease and demonstrated diffuse metastatic visceral calcifications of lungs, myocardium, stomach, kidneys and thyroid on follow-up 99mTc-methylene diphosphonate bone scan. In the absence of extensive skeletal metastases, bone scan help confirm humoral nature of hypercalcaeimia.

Topics: Adult; Bone and Bones; Calcinosis; Humans; Hypercalcemia; Male; Paranasal Sinus Neoplasms; Prognosis; Radionuclide Imaging; Sphenoid Sinus; Technetium Tc 99m Medronate

Topics: Accidental Falls; Aged, 80 and over; Aneurysm, False; Calcinosis; Femoral Artery; Humans; Male; Peripheral Vascular Diseases; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Ultrasonography; Whole Body Imaging

A 51-year-old woman on peritoneal dialysis for chronic renal failure secondary to diabetic and nonsteroidal anti-inflammatory drug nephropathy was referred for a Tc-99m MDP bone scan to assess firm subcutaneous plaques in the sacral and gluteal regions. This showed extensive superficial tracer localization in the subcutaneous tissues as well as visceral tracer activity in the myocardium, lungs, stomach, and kidneys. These findings were typical for calciphylaxis (calcific uremic arteriolopathy), a form of metastatic calcification encountered in patients with chronic renal failure that is characterized by subcutaneous soft tissue calcification, painful ulcerations, high morbidity, and mortality. Treatment with sodium thiosulfate resulted in dramatic scintigraphic improvement.

Topics: Bone and Bones; Calcinosis; Calciphylaxis; Female; Humans; Ischemia; Kidney Failure, Chronic; Middle Aged; Necrosis; Neoplasm Metastasis; Radionuclide Imaging; Technetium Tc 99m Medronate; Thiosulfates; Tissue Distribution

Metastatic calcification, a known complication of prolonged end-stage renal disease, is herein described for the first time in a 10-month-old boy with acute renal failure, manifesting as a painful and swollen arm. Imaging revealed diffuse calcification and technetium-99 methylene diphosphonate (99Tc-MDP) uptake around the humerus and axilla. Calcium and vitamin D restriction, followed by intravenous administration of sodium thiosulfate caused a full symptomatic, radio- and scintigraphic improvement.

Topics: Acute Kidney Injury; Calcinosis; Humans; Infant; Male; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Calcinosis; Diagnosis, Differential; Female; Humans; Lung Diseases; Middle Aged; Pulmonary Alveoli; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Adenocarcinoma; Calcinosis; Chronic Disease; Female; Humans; Hypercalcemia; Hyperparathyroidism; Kidney Failure, Chronic; Lung; Lung Neoplasms; Middle Aged; Ossification, Heterotopic; Peritoneal Dialysis, Continuous Ambulatory; Radiopharmaceuticals; Respiratory Function Tests; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Whole Body Imaging

Topics: Bone and Bones; Calcinosis; Humans; Male; Middle Aged; Penile Induration; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Whole Body Imaging

We report computed tomography (CT) findings that demonstrated early disappearance of ectopic calcification in the bilateral posterior paraspinal muscles in a patient with rhabdomyolysis. A 37-year-old man with acute renal failure due to rhabdomyolysis caused by neuroleptic malignant syndrome underwent studies with CT and bone scintigraphy. First, bone scintigraphy showed high radiotracer uptake in bilateral posterior paraspinal muscles; then CT demonstrated ectopic calcification in those muscles. After 2.5 months, CT showed that the calcification had completely disappeared. Bone scintigraphy anticipated calcification, and CT demonstrated a unique course of early disappearance of the calcification.

Topics: Acute Kidney Injury; Adult; Biomarkers; Bone and Bones; Calcinosis; Humans; Male; Muscle, Skeletal; Neuroleptic Malignant Syndrome; Radionuclide Imaging; Radiopharmaceuticals; Rhabdomyolysis; Technetium Tc 99m Medronate; Time Factors; Tomography, X-Ray Computed

Topics: Calcinosis; Child; Humans; Male; Radionuclide Imaging; Radiopharmaceuticals; Skin Diseases; Technetium Tc 99m Medronate

Calciphylaxis is a highly morbid syndrome of vascular calcification and skin necrosis, the pathophysiology of which remains largely elusive. We report a patient with end-stage renal disease and multiple painful skin lesions who underwent a bone scan for extremity pain. Increased tracer accumulation was seen in the subcutaneous tissues of the trunk and lower extremities. In this case, the bone scan aided in the diagnosis and treatment of calciphylaxis for a patient who experienced a relatively short hospital stay.

Topics: Aged; Bone and Bones; Calcinosis; Calciphylaxis; Female; Humans; Kidney Failure, Chronic; Necrosis; Radionuclide Imaging; Radiopharmaceuticals; Skin Ulcer; Syndrome; Technetium Tc 99m Medronate; Vascular Diseases

Topics: Bone and Bones; Calcinosis; Female; Humans; Intestinal Diseases; Kidney Failure, Chronic; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

End-stage renal disease (ESRD) patients receiving chronic hemodialysis (HD) via an arteriovenous (A-V) access often develop unexplained pulmonary hypertension (PHT). This study evaluated the role of pulmonary calcification (PC) in this phenomenon.. The clinical manifestations, systolic pulmonary artery pressure (PAP) values measured by Doppler echocardiography and the presence and the extent of PC expressed by lung uptake of 99mTc-MDP bone scintigraphy, were studied in 49 patients with ESRD receiving chronic HD therapy via A-V access. The correlation between PC and PHT was investigated.. There were 36 men and 13 women with a mean age of 61.7 +/- 13.2 years receiving HD therapy for 38.2 +/- 43.7 months. Twenty (40.8%) patients had PC expressed by increased lung uptake of 99mTc- MDP and 28 (57.1%) patients had PHT with a mean systolic PAP of 46 +/- 11 mm Hg. No correlation was found between PC and PHT.. The data suggest that PC expressed by lung uptake of 99mTc-MDP has no role in the pathogenesis of PHT among ESRD patients undergoing HD therapy via A-V access.

Topics: Adult; Aged; Aged, 80 and over; Bone and Bones; Calcinosis; Female; Humans; Kidney Failure, Chronic; Lung Diseases; Male; Middle Aged; Pulmonary Wedge Pressure; Radionuclide Imaging; Radiopharmaceuticals; Renal Dialysis; Technetium Tc 99m Medronate

Topics: Bone and Bones; Calcinosis; Connective Tissue Diseases; Edema; Humans; Male; Radionuclide Imaging; Radiopharmaceuticals; Renal Dialysis; Soft Tissue Neoplasms; Technetium Tc 99m Medronate

Topics: Adult; Calcinosis; Cardiomyopathies; Connective Tissue Diseases; Humans; Kidney Failure, Chronic; Male; Radionuclide Imaging; Radiopharmaceuticals; Renal Dialysis; Technetium Tc 99m Medronate

Topics: Abdominal Neoplasms; Bone Neoplasms; Calcinosis; Child; Diagnosis, Differential; Female; Humans; Ovarian Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Teratoma

A 78-year-old Korean woman was referred to Chonbuk National University Dental Hospital complaining of facial palsy and palpable mass in the right parotid gland area for 4 years. Clinical examination showed an asymmetrical facial appearance due to a 4 cmx5 cm hard, fixed, non-tender mass in the right parotid gland area, incomplete eye closure and a slight tremor at the corner of the mouth. A panoramic radiograph showed an amorphous calcified mass on the posterior mandibular ramus with thinning of the cortical plate adjacent to the mass. A sialogram showed constriction of the main duct and no further filling of striated, intercalated ducts and parenchymal areas. CT indicated an expansile mass with slight contrast enhancement involving the right parotid gland. The large mass showed necrotic areas and calcifications. A bone scan showed marked accumulation of (99)Tc(m)-methylene diphosphonate on the right posterior maxilla. Microscopic findings revealed minimal morphological alterations and rare mitotic figures within tumour cells, and the lesion was diagnosed as adenocarcinoma not otherwise specified (NOS, grade II).

Topics: Adenocarcinoma; Aged; Calcinosis; Female; Humans; Parotid Neoplasms; Radiography, Panoramic; Radiopharmaceuticals; Sialography; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Metastatic calcifications are associated with chronic renal failure, hyperparathyroidism, metastatic neoplasms, hypervitaminosis D, and hypercalcemia of other origins. Bone scanning agents accumulate within these extraskeletal metastatic calcifications. The authors describe two patients with hypercalcemia associated with Tc-99m MDP uptake in the lungs, stomach, and soft tissues. Ga-67 scintigraphy was also performed and showed increased uptake in the same locations as those of Tc-99m MDP, suggesting the existence of an inflammatory process. Despite adequate treatment, only partial resolution of extraskeletal uptake was observed.

Topics: Aged; Bone and Bones; Calcinosis; Connective Tissue; Female; Gallium Radioisotopes; Humans; Hypercalcemia; Lung; Male; Radionuclide Imaging; Radiopharmaceuticals; Stomach; Technetium Tc 99m Medronate

Topics: Bone Neoplasms; Calcinosis; Diagnosis, Differential; Gastric Mucosa; Humans; Lung; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Ribs; Stomach; Technetium Tc 99m Medronate; Whole-Body Counting

Topics: Calcinosis; Calcium; Female; Goiter; Humans; Hypercalcemia; Hypoparathyroidism; Lung; Middle Aged; Postoperative Complications; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Thyroidectomy; Vitamin D

Topics: Bone and Bones; Calcinosis; Connective Tissue; Diagnosis, Differential; Foot; Hand; Humans; Incidental Findings; Infant; Male; Osteomyelitis; Radionuclide Imaging; Radiopharmaceuticals; Skin; Technetium Tc 99m Medronate

Topics: Abdominal Neoplasms; Abdominal Wall; Aged; Calcinosis; Diagnosis, Differential; Humans; Male; Plasma Cell Granuloma, Pulmonary; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Soft Tissue Neoplasms; Solitary Pulmonary Nodule; Technetium Tc 99m Medronate

Topics: Bone and Bones; Calcinosis; Cystadenocarcinoma; Female; Humans; Ovarian Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Umbilicus

A 68-year-old man with a history of prostate carcinoma and increasing levels of prostate-specific antigen was referred for a radionuclide bone scan. In addition to a probable metastatic lesion in the right femoral head, focal radiotracer accumulation was seen overlying the left aspect of the urinary bladder. Plain radiographs and pelvic computed tomography confirmed the presence of a calcified mass in the bladder. Cystoscopic examination revealed an exophytic bladder lesion. Biopsy indicated low-grade papillary transitional cell carcinoma, and the patient successfully underwent transurethral resection of this tumor.

Topics: Aged; Bone Neoplasms; Calcinosis; Carcinoma, Transitional Cell; Femur; Humans; Male; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Urinary Bladder; Urinary Bladder Neoplasms

Topics: Aged; Calcinosis; Female; Humans; Hyperostosis Frontalis Interna; Meningioma; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Adenocarcinoma, Papillary; Calcinosis; Female; Humans; Middle Aged; Ovarian Neoplasms; Peritoneal Neoplasms; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Topics: Adult; Bone and Bones; Breast Neoplasms; Calcinosis; Female; Humans; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Bone and Bones; Calcinosis; Female; Heart; Humans; Kidney Failure, Chronic; Lung; Male; Middle Aged; Radionuclide Imaging; Renal Dialysis; Technetium Tc 99m Medronate; Uremia

Metastatic calcification associated with renal failure is well described. Bone scanning agents accumulate to various degrees within extraskeletal sites of metastatic calcification. The authors describe a patient with polycystic kidney disease resulting in renal failure, with the subsequent development of secondary hyperparathyroidism and metastatic calcification. Bone scintigraphy revealed abnormal uptake in both lungs, the right leg, and the right hand.

Topics: Calcinosis; Female; Hand; Humans; Hyperparathyroidism, Secondary; Kidney Failure, Chronic; Lung Diseases; Middle Aged; Muscular Diseases; Polycystic Kidney, Autosomal Dominant; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Technetium Tc 99m Sestamibi; Thigh; Thumb

A 31-year-old woman visited an out-patient clinic, because of low-grade fever and general fatigue. She was referred to our hospital and admitted for examination of an abnormal shadow which had been found on the chest radiograph. She had experienced faint right lateral chest pain several times on the deep inspirations. Chest radiography showed a mass shadow with calcification in the right lower lung field on the mediastinal side. Chest radiographic computed tomography showed a 6x6 cm tumor in the right lung field. There were low-density areas with septae inside the tumor. Bone scintigraphy showed extremely high uptake of (99m)Tc-HMDP in the tumor. After surgical resection and pathological examination, we concluded that the tumor was an extensively calcified benign hemangioma of the diaphragm.

Topics: Adult; Calcinosis; Diaphragm; Female; Hemangioma; Humans; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Aged; Bone and Bones; Bone Neoplasms; Calcinosis; Chronic Disease; Female; Humans; Pancreatitis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, X-Ray Computed; Uterine Cervical Neoplasms

Clinical and scintigraphic findings are described in a patient with unexpected diffuse lung uptake on bone scan after a heroin overdose.. The patient's Tc-99m MDP bone scan is reviewed along with the pertinent clinical history and laboratory findings.. Marked diffuse and symmetric lung uptake is present on bone scintigraphy in a patient with a history of acute renal failure and a markedly elevated calcium-phosphate product but normal renal function and laboratory values at the time of the examination.. The incidental observation of metastatic calcification by bone scintigraphy is important, because it may aid in the diagnosis of a previously unsuggested elevated calcium-phosphate product, renal failure, or both. Furthermore, the intensity of tracer localization on bone tracer-specific imaging may help evaluate the activity of the metastatic calcification process.

Topics: Acute Kidney Injury; Adult; Bone and Bones; Calcinosis; Drug Overdose; Heroin; Heroin Dependence; Humans; Lung Diseases; Male; Narcotics; Radionuclide Imaging; Radiopharmaceuticals; Rhabdomyolysis; Technetium Tc 99m Medronate

Two children with juvenile dermatomyositis and extensive, debilitating soft tissue calcifications are described. Whole-body bone scans with Tc-99m MDP were performed in both cases before and during specific treatment for the calcinosis. Baseline studies showed marked tracer localization in the soft tissues and provided an objective baseline assessment of the extent of the soft tissue calcifications. Follow-up studies showed gradual clearance of the extraskeletal uptake and were useful in monitoring the therapeutic response. These cases show that skeletal scintigraphy can function as a useful auxiliary tool to evaluate calcinosis in children with juvenile dermatomyositis.

Topics: Bone and Bones; Calcinosis; Child, Preschool; Dermatomyositis; Female; Follow-Up Studies; Humans; Male; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Time Factors

A patient with chronic renal failure and secondary hyperparathyroidism had iliac bone biopsy. The procedure was complicated by a soft-tissue hematoma, which had calcified. A 3-4-cm palpable mass was visible in the lower left abdominal wall. Intense uptake of 99mTc-HMDP corresponded with the location of the calcified hematoma in this patient.

Topics: Adult; Biopsy; Bone and Bones; Calcinosis; Hematoma; Humans; Hyperparathyroidism, Secondary; Kidney Failure, Chronic; Male; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Adult; Bone and Bones; Calcinosis; Dermatomyositis; Female; Humans; Pelvic Bones; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Whole-Body Counting

A report is presented of a liquefaction necrosis of mitral annular calcification in a patient with chronic renal failure and secondary hyperparathyroidism who had been managed by hemodialysis for 11 years. The mass was echogenic with an echo-lucent area inside, high density on computed tomography and low intensity on magnetic resonance imaging. The uptake of gallium-67 (67Ga)-citrate and the bone agent technetium-99m-methylene diphosphate (99mTc-MDP) was seen in the mass. These findings were compatible with liquefaction necrosis of the mitral annular calcification. After treatment with low calcium concentration hemodialysis, the size of the mass reduced with disappearance of the echo-lucent area on the echocardiography and there was no uptake of 67Ga-citrate or 99mTc-MDP. Liquefaction necrosis might be the early and reversible form of mitral annular calcification. When a tumorlike echogenic mass at the base of mitral leaflets is seen in patients with predisposing factors for mitral annular calcification, consider the possibility of this specific form of mitral annular calcification in order to avoid any unnecessary surgical intervention.

Topics: Calcinosis; Calcium; Citrates; Echocardiography; Female; Gallium; Gallium Radioisotopes; Heart Valve Diseases; Humans; Kidney Failure, Chronic; Magnetic Resonance Imaging; Middle Aged; Mitral Valve; Necrosis; Radiopharmaceuticals; Renal Dialysis; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Topics: Blood Vessel Prosthesis; Calcinosis; Catheters, Indwelling; Female; Groin; Hip Joint; Humans; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Renal Dialysis; Technetium Tc 99m Medronate

The role of scintimammography with 99mTc-MDP was investigated in patients with mammographic or clinical evidence of breast lesions, suspicious for malignancy, in our Department at the National Cancer Institute of Naples. The end-point of the study was to assess the uselfulness of this test in diagnosing or ruling out breast cancer in more than 2000 women. Scintimammography results were compared with those of mammography and ultrasound and categorized according to histological findings. Overall sensitivity was 92%, specificity was 90%, and accuracy 91%. Sensitivity was affected by the lesions exceeding 12 mm and specificity by sclerotic and/or hyaline or myxoid fibroadenomas, which may be positive. The major advantages of scintimammography appeared in the study of calcifications without a mass and of the indirect mammographic signs of breast cancer, such as distortion and asymmetry. Scintimammography with 99mTc-MDP is a reliable, safe and highly cost-effective procedure to diagnose or to rule out breast cancer, after mammography and ultrasound have yielded questionable results.

Topics: Breast Neoplasms; Calcinosis; Diagnosis, Differential; Female; Humans; Mammography; Radionuclide Imaging; Sensitivity and Specificity; Technetium Tc 99m Medronate

Topics: Adult; Calcinosis; Cystadenocarcinoma, Papillary; Female; Humans; Lymphatic Metastasis; Mediastinal Neoplasms; Ovarian Neoplasms; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Bone and Bones; Calcinosis; Child; Female; Humans; Liver Neoplasms; Neuroectodermal Tumors, Primitive; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Bone and Bones; Calcinosis; Gallbladder; Gallbladder Diseases; Humans; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate

Topics: Calcinosis; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Splenic Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

We present a case of transitional cell carcinoma of the bladder visualized by 99mTc-HMDP bone scintigraphy and suggest possible uptake mechanisms. Pelvic CT demonstrated a sessile bladder tumor with punctate and curvilinear calcifications on the surface areas (incrustation). Technetium-99m-HMDP bone scintigraphy demonstrated intense uptake corresponding to the site of the bladder tumor. Chemisorption of urinary 99mTc-HMDP, rather than of blood-born 99mTc-HMDP, may have occurred at the tumor surface.

Topics: Bone Neoplasms; Calcinosis; Carcinoma, Transitional Cell; Female; Humans; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Urinary Bladder Neoplasms

Uptake of Tc-99m MDP tracer was noted within prostatic calcifications in a 48-year-old man with no known malignancy who underwent a three-phase bone scan for left knee and thigh pain. Routine anterior and posterior views of the pelvis demonstrated focal tracer uptake within the right pubic bone, which mimicked a metastatic lesion. Additional imaging showed the uptake to be extraosseous and localized within the prostate in a distribution similar to the extensive prostatic calcifications seen on the corresponding plain film and computed tomography examinations of the pelvis. This unusual presentation illustrates another potential artifact that may be present in scintigraphic bone imaging of the pelvis.

Topics: Bone and Bones; Bone Neoplasms; Calcinosis; Diagnosis, Differential; Humans; Male; Middle Aged; Prostatic Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate

Metastatic calcification within soft tissue, such as the lung and stomach, is associated with hyperparathyroidism, chronic renal failure, hemodialysis, metastatic neoplasm and hypervitaminosis D. Bone scanning agents variably accumulate within these extraskeletal metastatic calcifications. We report a patient with primary hyperparathyroidism whose bone scan revealed abnormal uptake in the liver, lung, stomach and parathyroid gland followed by complete resolution of extraskeletal uptake less than 1 wk after parathyroidectomy.

Topics: Adenoma; Aged; Bone and Bones; Calcinosis; Female; Humans; Hypercalcemia; Hyperparathyroidism; Parathyroid Neoplasms; Parathyroidectomy; Radionuclide Imaging; Technetium Tc 99m Medronate

We report on 99mTc-MDP uptake in lungs and stomach in a patient with hypercalcaemia and renal failure due to elevated 1,25(OH)2vitD3 because of sarcoidosis. Presently, this typical scan pattern has only been described in patients with malignancies, parathyroid adenoma and drug-induced vitamin D intoxication. We offer possible explanations for the findings in our patient.

Topics: Aged; Bone and Bones; Calcinosis; Humans; Hypercalcemia; Lung Diseases; Male; Radionuclide Imaging; Sarcoidosis; Stomach Diseases; Technetium Tc 99m Medronate

We describe herein a case of parathyroid carcinoma accompanied with metastatic calcification identified by technetium-99m methylene diphosphonate (Tc-99m MDP) scintigraphy in the lungs, kidneys and stomach. Parathyroid carcinoma remains a rare disorder despite the increased prevalence of primary hyperparathyroidism. Metastatic calcification is noted infrequently even in primary hyperparathyroidism and it may cause respiratory failure. Tc-99m MDP scintigraphy three months after surgery showed a complete disappearance of Tc-99m uptake in the stomach and an obvious reduction in the kidneys but no significant change in the lungs, indicating metastatic calcification can be reversibly reabsorbed. This case indicates that the adequate excision of parathyroid carcinoma as well as the early detection of metastatic calcification by Tc-99m MDP are obligatory.

Topics: Calcinosis; Carcinoma; Female; Humans; Hypercalcemia; Kidney Neoplasms; Lung Diseases; Middle Aged; Neoplasm Invasiveness; Parathyroid Neoplasms; Radionuclide Imaging; Respiratory Insufficiency; Stomach Diseases; Technetium Tc 99m Medronate

The authors present a case of extensive soft-tissue radioactivity visualized on both 99mTc-MDP and 201Tl-chloride scintigrams in a patient with dermatomyositis and colon cancer. Incidentally, diffuse and intense uptake of 99mTc-MDP was observed in the shoulder girdles, anterior chest wall, psoas muscles, both proximal thighs and right lower limb, corresponding to the sites of symptomatic muscles, even though skin lesions were limited and no calcification was detected on radiographs. Moreover, 201Tl-chloride was also intensely accumulated in nearly the same sites as the symptomatic muscles as shown on the 99mTc-MDP bone scintigrams. Whole-body scintigraphy with 99mTc-MDP and 201Tl-chloride is a useful tool to detect occult muscle lesions with dystrophic calcification and hyperemia in dermatomyositis.

Topics: Calcinosis; Colonic Neoplasms; Dermatomyositis; Humans; Male; Middle Aged; Muscles; Radionuclide Imaging; Technetium Tc 99m Medronate; Thallium; Thallium Radioisotopes

Localization of skeletal tracer in a neuroblastoma primary is common but localization in extraskeletal metastatic sites has not received recognition. Tc-99m MDP concentration in hepatic or pulmonary metastases was noted in three of ten patients with such metastases. Lesion size appears to be important for demonstrating these metastases with Tc-99m MDP. This was particularly true for hepatic metastases, which were identified only when they were 5 cm or greater in diameter.

Topics: Bone and Bones; Calcinosis; Child; Child, Preschool; Contrast Media; Female; Follow-Up Studies; Gadolinium; Humans; Image Enhancement; Infant; Infant, Newborn; Liver Neoplasms; Lung Neoplasms; Magnetic Resonance Imaging; Male; Neoplasm Staging; Neuroblastoma; Radiography, Thoracic; Radionuclide Imaging; Radiopharmaceuticals; Retrospective Studies; Technetium Tc 99m Medronate

The purpose of this study was to evaluate the frequency and the extent of extraosseous 99mTc-HMDP accumulation in 412 patients with primary lung cancer. CT scanning was also performed and we compared the extraosseous uptake by lung cancer with the internal structure of the tumor on CT scans. The extent of ectopic 99mTc-HMDP accumulation was classified as low, moderate or high. CT scans were used to evaluate the size and internal structure of the tumor, including calcification and necrosis. Ectopic 99mTc-HMDP accumulation in primary lung cancer was found in 32 patients (7.7%), and included 2 cases (0.5%) of high uptake, 8 cases (1.9%) of moderate uptake, and 22 cases (5%) of low uptake. No difference in uptake was observed among the histological types, but a relationship between tumor size and 99mTc-HMDP extraosseous accumulation was observed. CT scans of the 32 tumors exhibiting ectopic 99mTc-HMDP accumulation revealed 5 cases of calcification in the tumor and 18 cases of tumor necrosis. The factors promoting ectopic 99mTc-HMDP accumulation were considered to be tumor size and calcification or necrotic change. In patients with neither calcification nor necrosis, other factors such as increased calcium metabolism and altered vascular permeability may be involved.

Topics: Adenocarcinoma; Calcinosis; Carcinoma, Large Cell; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Necrosis; Technetium Tc 99m Medronate; Tomography, Emission-Computed; Tomography, X-Ray Computed

A 51-year-old man was found to have hepatic metastasis from colon carcinoma. Bone scintigraphy with 99mTc-hydroxymethylene diphosphonate showed a ringlike accumulation corresponding to the hepatic mass, which was without calcification on computed tomography. Treatment with chemotherapeutic agents was started. After 4 months, computed tomography showed that the mass was smaller than before and that the margin was calcified. The extraosseous accumulation of the radionuclide may be evidence supporting earlier speculation on calcification that could not yet be detected by computed tomography.

Topics: Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Calcinosis; Cisplatin; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Technetium Tc 99m Medronate; Tomography, Emission-Computed; Tomography, X-Ray Computed

Diffuse pulmonary uptake of both technetium-99m- labeled methylene diphosphonate (99(m)Tc-MDP) and gallium (67Ga) citrate was noted in a patient with chronic renal failure and indicated the presence of pulmonary calcinosis. The uptake of 67Ga could be misinterpreted to represent abnormal uptake due to an opportunistic infection.

Topics: Adolescent; Calcinosis; Female; Gallium Radioisotopes; Humans; Kidney Failure, Chronic; Lung; Lung Diseases; Opportunistic Infections; Radionuclide Imaging; Radiopharmaceuticals; Renal Dialysis; Staphylococcal Infections; Technetium Tc 99m Medronate

Topics: Adult; Calcinosis; Exostoses; Femoral Fractures; Fractures, Ununited; Humans; Knee; Knee Injuries; Male; Ossification, Heterotopic; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Metastatic calcification is often detected by bone scintigraphy. We recently saw metastatic calcification in the stomach and kidneys of a patient on continuous ambulatory peritoneal dialysis. Tc-99m HMDP accumulation into both organs was noted even in the first frame of dynamic data acquisition of 4 min/frame, suggesting that calcium deposits may create an aggressive process and we may obtain information on the calcium deposit rate to better understand the mechanism of metastatic calcification.

Topics: Aged; Bone and Bones; Calcinosis; Calcium; Female; Humans; Kidney Diseases; Peritoneal Dialysis, Continuous Ambulatory; Radiopharmaceuticals; Stomach Diseases; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon

Topics: Bone and Bones; Calcinosis; Citrates; Citric Acid; Gallium Radioisotopes; Humans; Hypercalcemia; Kidney Failure, Chronic; Lung Diseases; Radionuclide Imaging; Stomach Diseases; Technetium Tc 99m Medronate

Topics: Adult; Bone and Bones; Calcinosis; Chronic Kidney Disease-Mineral and Bone Disorder; Female; Humans; Radionuclide Imaging; Renal Dialysis; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Metastatic pulmonary calcification (MPC), a complication of chronic renal failure, is uncommonly diagnosed antemortem, yet may be a significant etiology of pulmonary dysfunction in patients with renal failure. The degree of respiratory distress often does not correlate with the degree of macroscopic calcification. Patients with extensive calcification may be asymptomatic, while others with subtle calcification or normal chest radiographs may have severe respiratory compromise. Additionally, the findings on chest radiographs may be confused with air-space disease, including pulmonary edema and pneumonia. Radionuclide imaging may detect MPC in the setting of normal chest radiographs, and confirm the diagnosis when there are radiographic findings of air-space disease without macroscopic calcification. We present a patient with bilateral upper lobe disease suspected to represent edema or pneumonia, proven to represent MPC on 99mTc MDP scintigraphy with single photon emission computed tomography (SPECT), CT, and later at transbronchial biopsy.

Topics: Bone and Bones; Calcinosis; Diagnosis, Differential; Humans; Kidney Failure, Chronic; Lung Diseases; Male; Middle Aged; Pneumonia; Pulmonary Edema; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

A radionuclide bone scan serendipitously revealed deposition of Tc-99m MDP in multiple lumbar intervertebral disk spaces in a 29-year-old man with extensive trauma to the left femur as a result of a motor vehicle accident. In the authors' experience, alcoholic liver disease or altered weight bearing secondary to prior trauma are not associated with intervertebral radiotracer uptake. Although it is possible that radiographically undetectable microcalcifications in the intervertebral disk spaces associated with degenerative changes, common in Scheuermann disease, account for this unusual finding, a literature search found that increased disk uptake had been reported only in two patients with Scheuermann disease who had concomitant active or healing diskitis. No other causes of increased disk uptake of Tc-99m MDP were found.

Topics: Adult; Calcinosis; Discitis; Humans; Intervertebral Disc; Lumbar Vertebrae; Male; Radiography; Radionuclide Imaging; Scheuermann Disease; Technetium Tc 99m Medronate

The side effects of prolonged isotretinoin therapy include progressive calcification of ligamentous and tendon insertions, premature fusion of epiphyses, and modeling abnormalities of long bones. Increased calcification of gastric mucosa has been reported only in animal studies, but not in humans. A case of a child who was treated with isotretinoin for 26 months for a dermatologic disorder and who showed abnormal gastric uptake of 99m-Tc MDP on a bone scan is reported.

Topics: Bone and Bones; Calcinosis; Child; Female; Humans; Isotretinoin; Pityriasis Rubra Pilaris; Radionuclide Imaging; Stomach; Stomach Diseases; Technetium Tc 99m Medronate; Time Factors

A 29-year-old male with generalized arterial calcification is presented. The roentgenogram showed extensive calcification bilaterally in the facial, brachial, renal, external iliac, femoral, and popliteal arteries. There was also calcification around the joints of the fingers, toes, elbows, and shoulders. The uniformity of arterial calcification in the radiograph differentiated this lesion from Mönckeberg's arteriosclerosis. The serum concentration levels of calcium, phosphorus, alkaline phosphatase, and calcium regulatory hormones were normal. The patient did not have diabetes mellitus, renal disease, or connective tissue disease, thus the etiology of the calcification was not identified. However, a bone scintigram showed that the uptake of 99 mTc-methylene diphosphate was significantly increased in the calcified arteries. Therefore, increased metabolic activity was associated with the derangement leading to arterial calcification.

Topics: Adult; Angiography; Arterial Occlusive Diseases; Bone and Bones; Calcinosis; Humans; Intermittent Claudication; Male; Technetium Tc 99m Medronate

A 49-year-old woman had longstanding renal impairment. Markedly increased uptake of Tc-99m MDP in the heart, lungs, and kidneys was an incidental finding on bone scintigraphy performed to exclude metastatic bone disease. These findings persisted on repeat bone imaging 1 year later. In addition, gastric and skeletal muscle uptake was subsequently seen. Soft tissue microcalcification was confirmed by computed tomography and renal biopsy. A consideration of the differential diagnosis is presented.

Topics: Bone Neoplasms; Calcinosis; Diagnosis, Differential; Female; Humans; Kidney; Lung; Middle Aged; Myocardium; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Adult; Bone and Bones; Calcinosis; Humans; Male; Muscular Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate; Uremia

Metastatic calcifications according to histopathologic and scintigraphic findings have been well-defined. The authors report a postoperative case of hyperparathyroidism with multiple metastatic calcifications in the lung, kidney, stomach, heart, and vessels that were primarily detected by bone scintigraphy and demonstrated by CT. Tc-99m MDP bone scintigraphy showed a markedly increased accumulation of radioactivity diffusely throughout the lung, left ventricular wall, both kidneys, and the gastric cardia and body. In the lung, plain films showed almost normal lung. CT, however, demonstrated patchy, slightly increased densities in the lung bilaterally. Cardiac CT indicated a considerably increased density of the ventricular myocardium and remarkable calcification in or near the atrioventricular septum or annulus fibrosus. Upper abdominal CT demonstrated increased densities diffusely throughout the gastric mucosa and renal cortex. Only vascular calcifications were depicted by plain films. Using both bone scintigraphy and CT provides accurate information about each lesion and each tissue, allowing precise diagnosis of even a questionable lesion in the early stage of metastatic calcification. Early diagnosis and early therapy offer the best chance for cure or palliative therapy.

Topics: Bone and Bones; Calcinosis; Female; Humans; Hyperparathyroidism; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

We report a case of primary amyloidosis with calcification of systemic lymphnodes which were demonstrated as positives by bone scintigraphy. Positive sites delineated by bone scintigraphy would seem likely to reflect avid calcification of amyloid deposits. The discovery of positive systemic lymphnodes by bone scintigraphy is very rare in a routine study and may allow for amyloidosis in a differential diagnosis.

Topics: Amyloidosis; Axilla; Calcinosis; Groin; Humans; Lymphatic Diseases; Male; Middle Aged; Neck; Radionuclide Imaging; Technetium Tc 99m Medronate

A 3 1/2-year-old boy had thigh pain and a leg mass. Bone scanning demonstrated intense uptake within the involved femur, but no uptake within the soft tissues or evidence of metastatic spread. Radiographs and CT scanning showed a large soft tissue mass and periosteal reaction suggestive of Ewing's sarcoma. Following chemotherapy, the patient had an apparently good clinical response. However, bone scanning showed uptake that was more intense and extensive than it was before therapy. Plain films and CT showed that the uptake was evidence of soft tissue calcification and that the mass had shrunk. This is an unusual example of the flare response to therapy because the apparent progression of the disease on bone scanning was caused by extraskeletal uptake.

Topics: Antineoplastic Combined Chemotherapy Protocols; Calcinosis; Child, Preschool; Femoral Neoplasms; Humans; Male; Radionuclide Imaging; Sarcoma, Ewing; Technetium Tc 99m Medronate

An unusual distribution of Tc-99m MDP and Ga-67 citrate in several muscle groups is described in a 14-year-old boy with aplastic anemia and normal renal function at the time of imaging. Although the patient did not develop musculo-skeletal signs or symptoms, a subsequent autopsy revealed widespread muscle calcification.

Topics: Adolescent; Anemia, Aplastic; Calcinosis; Citrates; Citric Acid; Gallium; Gallium Radioisotopes; Humans; Male; Muscles; Muscular Diseases; Radionuclide Imaging; Technetium Tc 99m Medronate

A patient with blastomycosis complained of pain in his lower back after the administration of amphotericin B and parenteral alimentation via a femoral venous catheter. A bone scan that was performed to exclude bony involvement with blastomycosis showed abnormal tracer accumulation in the right paravertebral region. Computed tomography revealed the venous catheter to lie in the right ascending lumbar vein. There was calcification of a portion of the right psoas muscle. In addition, the epidural venous plexus was calcified from L2 to L4. It was this dystrophic calcification that caused the heterotopic accumulation of bone tracer.

Topics: Adolescent; Blastomycosis; Calcinosis; Catheterization, Peripheral; Humans; Male; Phlebitis; Technetium Tc 99m Medronate

Topics: Calcinosis; Humans; Hypercalcemia; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate

A 99mTc-MDP scan was done on a patient with liver metastases from a medullary thyroid carcinoma who, in addition, had a familial history of multiple endocrine neoplasm, type 2. The scan revealed accumulation in several areas of calcified liver metastases.

Topics: Adult; Calcinosis; Carcinoma; Female; Humans; Liver Neoplasms; Radionuclide Imaging; Technetium Tc 99m Medronate; Thyroid Neoplasms

The bone scintigraphic findings of calcific discitis of childhood is described and one new case is presented. A brief review of the value of bone scintigraphy in the diagnosis of this syndrome as well as pathogenesis, clinical course, and treatment is provided.

Topics: Calcinosis; Child, Preschool; Discitis; Female; Humans; Radionuclide Imaging; Technetium Tc 99m Medronate

A 59-year-old woman with hypercalcemia due to hyperparathyroidism and 1-year-old boy with cryptogenic hypercalcemia were referred for bone scanning. There were increased accumulations of the technetium-phosphate complex in thyroid, stomach, lung, heart, and kidney. 99mTc-MDP bone scanning was useful for detecting metastatic calcification.

Topics: Calcinosis; Female; Humans; Hypercalcemia; Infant; Male; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Arthrography; Calcinosis; Diagnosis, Differential; Humans; Joint Diseases; Magnetic Resonance Imaging; Radionuclide Imaging; Shoulder Joint; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Topics: Calcinosis; Child; Connective Tissue Diseases; Humans; Male; Radionuclide Imaging; Technetium Tc 99m Medronate; Tumor Lysis Syndrome

An acute arthritis in a patient with mixed connective tissue disease (MCTD) was found to be associated with intra-articular deposition of carbonated hydroxyapatite crystals. A technetium hydroxymethylene diphosphonate bone scan showed intense uptake in the delayed phase scan of the affected joints. Synovial fluid analysis demonstrated uptake of the radiopharmaceutical drug directly onto the crystals.

Topics: Adult; Arthritis; Calcinosis; Crystallography; Female; Hand; Humans; Hydroxyapatites; Mixed Connective Tissue Disease; Radionuclide Imaging; Synovial Fluid; Technetium Tc 99m Medronate

Pulmonary calcification can be detected easily using Tc-99m phosphate compounds. Lung uptake of Tc-99m bone imaging agents was observed in two patients after liver transplantation. Transient hypercalcemia due to calcium infusion during hepatic transplantation may be responsible for the pulmonary calcification.

Topics: Calcinosis; Humans; Liver Transplantation; Lung; Lung Diseases; Male; Middle Aged; Postoperative Complications; Radionuclide Imaging; Technetium Tc 99m Medronate

Topics: Aged; Aged, 80 and over; Bone and Bones; Calcinosis; Diagnosis, Differential; Humans; Male; Radionuclide Imaging; Spleen; Splenic Artery; Technetium Tc 99m Medronate

SPECT was used to identify a focal accumulation of cardiac calcification using Tc-99m MDP in a patient with an arrhythmia and known metastatic calcification elsewhere.

Topics: Adult; Arrhythmias, Cardiac; Calcinosis; Cardiomyopathies; Humans; Male; Radiography; Technetium Tc 99m Medronate

Topics: Aged; Calcinosis; Female; Humans; Leiomyoma; Radionuclide Imaging; Technetium Tc 99m Medronate; Uterine Neoplasms

Topics: Adult; Calcinosis; Female; Humans; Neck; Radionuclide Imaging; Technetium Tc 99m Medronate

Focal uptake of 99mTc-MDP was seen in a case of hepatoblastoma. The focal uptake corresponded to an area of calcification on CT, which was shown histologically to consist of osteoid with mineralization. The mechanism of uptake by the tumor in this case is likely to be the same as for skeletal uptake.

Topics: Calcinosis; Carcinoma, Hepatocellular; Humans; Infant; Liver Neoplasms; Male; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate

In a 45-year old patient with serous cystadenocarcinoma of the ovary CT showed small calcifications in metastases along peritoneal surfaces. These "psammoma bodies" indicated abdominal implants, which in other respects would not have been demonstrable via CT scans because of their small size. During bone scintigraphy the calcifications caused unusual extraskeletal focal uptake of 99mTc-MDP in the abdomen.

Topics: Bone Neoplasms; Calcinosis; Cystadenocarcinoma; Female; Humans; Middle Aged; Ovarian Neoplasms; Peritoneal Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

In a patient with Pellegrini-Stieda disease, radiographs of the knees were unremarkable at the time the three-phase bone scintigraphy was abnormal. The results of follow-up radiographs three months later remained normal in the left knee, where local steroid injection was given, but revealed typical positive results in the right knee with no treatment. The three-phase bone scintigraphic pattern is rather typical and antedates the radiographic changes. Thus, the radionuclide technique would provide a useful procedure for the early diagnosis and treatment of Pellegrini-Stieda disease.

Topics: Adolescent; Calcinosis; Humans; Knee Joint; Ligaments, Articular; Male; Methods; Myositis Ossificans; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate; Tibia

Vitamin D intoxication, which may result from zealous intake of health food supplements, may cause metastatic calcification. This is the first reported case of a patient with vitamin D intoxication who had massive gastric uptake of [99mTc]MDP, but no lung uptake, with histologic documentation of the metastatic calcification by gastric biopsy. It is probable that the metastatic calcification was a highly metabolic process in this patient since the gastric uptake resolved within 3 wk when serum calcium and phosphate had returned to normal.

Topics: Bone and Bones; Calcinosis; Cholecalciferol; Female; Gastric Mucosa; Humans; Hypercalcemia; Lung; Middle Aged; Radionuclide Imaging; Sodium Pertechnetate Tc 99m; Stomach; Stomach Diseases; Technetium Tc 99m Medronate

Two cases of extra-osseous uptake of 99mTc-methylene diphosphonate (MDP) by non-osseous metastatic tumors are reported. One was a metastasis with ossification in the abdominal wall from carcinoma of the sigmoid colon and the other was a metastasis with calcification from an ovarian carcinoma. The mechanism of extra-osseous uptake of 99mTc-MDP is discussed. Bone scintigraphy can be a potential means to assess tumor spread with ossifications and calcifications.

Topics: Abdominal Neoplasms; Adenocarcinoma, Mucinous; Adult; Bone Neoplasms; Calcinosis; Cystadenocarcinoma; Female; Humans; Male; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Sigmoid Neoplasms; Technetium Tc 99m Medronate

Abnormal pulmonary uptake of Ga-67 citrate and Tc-99m MDP and reversible liver uptake of Tc-99m MDP was seen in a patient with hypercalcemia of lymphoma and biopsy-proven metastatic pulmonary calcification. Abnormal lung uptake of Tc-99m MDP may confirm the diagnosis of pulmonary calcification, lessening the need for invasive procedures to evaluate pathologic lung uptake of Ga-67 citrate.

Topics: Calcinosis; Female; Gallium Radioisotopes; Humans; Hypercalcemia; Liver; Lung; Lung Diseases; Lymphoma, Follicular; Middle Aged; Radionuclide Imaging; Technetium Tc 99m Medronate

Bone scanning agents are known to accumulate in extraskeletal sites. We report the case of a patient with primary hyperparathyroidism whose bone scan performed with [99mTc]HMDP revealed not only the classic pattern described in hyperparathyroidism, but also a striking visceral uptake in the lungs, heart, stomach, and thyroid gland. Metastatic calcification was found on histologic examination of the thyroid.

Topics: Aged; Bone and Bones; Calcinosis; Humans; Hyperparathyroidism; Radionuclide Imaging; Technetium Tc 99m Medronate; Thyroid Diseases

Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Bone Diseases; Bone Neoplasms; Calcinosis; Female; Humans; Male; Middle Aged; Osteonecrosis; Pain; Radionuclide Imaging; Technetium Tc 99m Medronate

Sixteen children and adolescents undergoing regular haemodialysis treatment were studied for the occurrence of metastatic calcifications. By the use of diphosphonate bone-scanning, roentgenography of the chest and skull and ocular slit lamp examination, generalized visceral calcification was diagnosed in two patients. No relationship between visceral calcification and biochemical, radiological or histological abnormalities of renal osteodystrophy was found. Our study demonstrates that visceral calcification also occurs in children with chronic renal failure and may be detected by scintigraphy.

Topics: Adolescent; Adult; Bone and Bones; Calcinosis; Child; Female; Humans; Kidney Failure, Chronic; Male; Radiography; Radionuclide Imaging; Renal Dialysis; Technetium Tc 99m Medronate; Viscera

A case of nonsecretory multiple myeloma is presented. Radiological findings and bone marrow examination provided the diagnosis. Bone scintigraphy showed metastatic pulmonary calcification, thus demonstrating the potential superiority to any other routine diagnostic modality in detection of visceral calcification.

Topics: Adult; Biopsy; Bone Marrow; Calcinosis; Humans; Lung Neoplasms; Male; Multiple Myeloma; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate

Abnormal accumulation of Tc-99m MDP in two metastatic lesions of the liver was observed in a patient with resected colon carcinoma. Single-photon emission computed tomography (SPECT) revealed characteristic marginal accumulation of Tc-99m MDP in both of those metastatic lesions. X-ray CT showed the corresponding marginal calcification in one of the metastases, but no apparent calcification was observed in the other lesion. Two months later, however, the latter also became calcified on x-ray CT. These findings suggest that the accumulation of Tc-99m MDP in the present case is strongly related to the calcium deposition and that Tc-99m MDP may accumulate in a calcified metastatic lesion before the calcification appears on x-ray CT.

Topics: Calcinosis; Colonic Neoplasms; Diphosphonates; Female; Humans; Liver Neoplasms; Middle Aged; Technetium; Technetium Tc 99m Medronate; Tomography, Emission-Computed; Tomography, X-Ray Computed

We report a case of adult T-cell leukemia with increased uptake in both lungs which was detected by a bone scan using 99mTc-MDP. This finding is thought to have been caused by the metastatic calcification which is associated with ectopic parathormone production.

Topics: Adult; Calcinosis; Diphosphonates; Humans; Leukemia; Lung Neoplasms; Male; Radionuclide Imaging; T-Lymphocytes; Technetium; Technetium Tc 99m Medronate

A patient with a benign calcified pulmonary focus concentrating 99mTc-methylenediphosphonate is described. To the best of our knowledge, this is the first description of the accumulation of 99mTc-phosphate compounds in a benign calcified focus of the lung. The value of a routine correlation with X-ray study in every case of focal chest concentration of 99mTc-MDP is emphasized.

Topics: Bone and Bones; Calcinosis; Diphosphonates; Humans; Lung Diseases; Male; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Calcinosis; Diphosphonates; Female; Humans; Lung; Lung Diseases; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Bone and Bones; Calcinosis; Femoral Artery; Humans; Radionuclide Imaging; Technetium Tc 99m Medronate

A rare case of extensive dermal uptake of Tc-99m MDP associated with renal failure is reported. The mechanism of Tc-99m MDP uptake in such examples of metastatic calcification is not proved, but may relate to adsorption onto hydroxyapatite crystals. This phenomenon is useful in demonstrating distribution of nonvisceral metastatic calcification.

Topics: Adult; Calcinosis; Female; Humans; Kidney Failure, Chronic; Liver; Liver Cirrhosis; Polycystic Kidney Diseases; Radionuclide Imaging; Skin; Skin Diseases; Technetium Tc 99m Medronate

We present a case of multiple myeloma in which pulmonary calcification was clinically shown by bone scintigraphy and subsequently confirmed at autopsy. It is suggested that, in patients with myeloma, radionuclide bone scanning may be of value for differentiating deposits in the lung due to calcification from those due to other types of pulmonary infiltration revealed by chest X-rays. A thorough review of the relevant literature is presented.

Topics: Bone and Bones; Calcinosis; Humans; Hypercalcemia; Lung Diseases; Male; Middle Aged; Multiple Myeloma; Radionuclide Imaging; Technetium Tc 99m Medronate

Sixty-six percent of 54 patients with neuroblastoma demonstrated uptake of bone-seeking radioagents by the primary tumor. This is a higher incidence than previously reported. Uptake was slightly more common in abdominal than thoracic tumors. There was a significant correlation between the size of the tumor and tracer uptake. Calcification was demonstrated in the primary tumor in almost 90% of the 54 patients. This is a much higher incidence of calcification than previously reported. Microscopy shows that the calcification is not always due to tumor necrosis; it also occurs in areas of viable tumor cells. Tracer uptake is believed to be related to calcium metabolism. The rate of metabolic activity rather than the total amount of calcium present within the tumor may be the most important factor in determining the amount of uptake. No significant relationship was found between tracer uptake and tumor stage or homovanillic acid and vanillylmandelic acid metabolic activity.

Topics: Abdominal Neoplasms; Bone and Bones; Calcinosis; Diphosphonates; Etidronic Acid; Female; Homovanillic Acid; Humans; Infant; Male; Neuroblastoma; Organotechnetium Compounds; Radionuclide Imaging; Technetium; Technetium Compounds; Technetium Tc 99m Medronate; Thoracic Neoplasms; Vanilmandelic Acid

Topics: Calcinosis; Diphosphonates; Female; Humans; Lung; Lung Diseases; Middle Aged; Radiography; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Biological fixation of the Christiansen endoprosthesis takes place gradually as a result of osteogenetic activity in the endosteal wall of the femur, which is subjected to mechanical stimulation by the madreporic shank of this prosthesis. The authors were able to monitor this biological process in 9 patients with the aid of bone scintigraphy.

Topics: Aged; Calcinosis; Diphosphonates; Female; Femoral Neck Fractures; Femur; Hip Prosthesis; Humans; Male; Middle Aged; Osteolysis; Osteoporosis; Postoperative Complications; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Wound Healing

A whole body bone scan obtained on a 21-year-old woman with sickle cell disease and chronic renal failure showed localization of the radionuclide diffusely in the stomach. The localization of the radionuclide represented metastatic calcification of the stomach caused by secondary hyperparathyroidism.

Topics: Adult; Bone and Bones; Calcinosis; Diphosphonates; Female; Humans; Hyperparathyroidism, Secondary; Radionuclide Imaging; Stomach Diseases; Technetium; Technetium Tc 99m Medronate

Topics: Adult; Animals; Bone and Bones; Calcinosis; Diphosphonates; False Positive Reactions; Female; Granuloma; Heparin; Humans; Injections, Subcutaneous; Male; Middle Aged; Rabbits; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Adult; Bone and Bones; Calcinosis; Calcium; Diphosphonates; Humans; Male; Middle Aged; Phosphorus; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Uremia

Of 42 radionuclide bone scans in 35 children with neuroblastoma, 21 were abnormal for the presence of skeletal metastases. Of the 21 abnormal scans, 16 were corroborated by positive bone-marrow biopsy or clinical data. The false-negative and false-positive rates for bone scanning were 4.8% and 9.5%, respectively. Calcification of the primary tumor was seen on pretreatment computed tomographic (CT) scans in 24 (89%) of 27 cases, while only 13 (48%) of 27 were detectable by plain radiographs. Uptake of technetium-99m methylene diphosphate (99mTc-MDP) by the primary tumor occurred in 20 of 27 cases, but correlation between tumor uptake and calcification was not statistically significant. All children with markedly elevated urinary vanillylmandelic acid exhibited primary tumor uptake. Survival was not affected independently by primary tumor uptake.

Topics: Bone Neoplasms; Calcinosis; Child; Diphosphonates; False Negative Reactions; False Positive Reactions; Humans; Neuroblastoma; Prognosis; Radionuclide Imaging; Retrospective Studies; Technetium; Technetium Tc 99m Medronate; Vanilmandelic Acid

Topics: Calcinosis; Child; Diphosphonates; Female; Humans; Radionuclide Imaging; Sarcoma, Synovial; Soft Tissue Neoplasms; Technetium; Technetium Tc 99m Medronate; Thigh

Topics: Bone Neoplasms; Breast; Breast Neoplasms; Calcinosis; Diagnosis, Differential; Diphosphonates; Female; Humans; Mammography; Mastectomy; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Adolescent; Calcinosis; Diphosphonates; Humans; Male; Radionuclide Imaging; Skin Diseases; Technetium; Technetium Tc 99m Medronate

Topics: Adenocarcinoma; Bone and Bones; Breast Neoplasms; Calcinosis; Diphosphonates; Female; Humans; Lung; Lung Neoplasms; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Acute Kidney Injury; Adult; Bone and Bones; Calcinosis; Diphosphonates; Humans; Lung Diseases; Male; Muscular Diseases; Radionuclide Imaging; Stomach Diseases; Technetium; Technetium Tc 99m Medronate

Topics: Bone and Bones; Calcinosis; Diphosphonates; Humans; Hyperparathyroidism; Joint Diseases; Male; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Calcinosis; Diphosphonates; Female; Fibroma; Head and Neck Neoplasms; Humans; Infant, Newborn; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Adult; Calcinosis; Diphosphonates; Humans; Hypocalcemia; Hypokalemia; Leg; Male; Muscles; Muscular Diseases; Radionuclide Imaging; Shoulder; Technetium; Technetium Tc 99m Medronate

Topics: Bone and Bones; Calcinosis; Chronic Kidney Disease-Mineral and Bone Disorder; Diphosphonates; Female; Humans; Male; Radionuclide Imaging; Renal Dialysis; Technetium; Technetium Tc 99m Medronate

Topics: Calcinosis; Child; Dermatomyositis; Diphosphonates; Humans; Male; Prognosis; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Calcinosis; Cardiomyopathies; Diphosphonates; Female; Humans; Hypercalcemia; Middle Aged; Myocardium; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Bone and Bones; Calcinosis; Calcium Metabolism Disorders; Diphosphonates; Humans; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Adult; Aged; Bone and Bones; Calcinosis; Diphosphonates; Female; Humans; Male; Middle Aged; Neoplasms; Radionuclide Imaging; Technetium; Technetium Compounds; Technetium Tc 99m Medronate

Forty patients, ages three days to 12 years, with neuroblastomas had bone scans with 99mtechnetium methylene diphosphonate (99mTc-MDP) as part of their pretreatment examination. Twenty-four (60%) had primary tumor uptake and 16 (40%) did not. No difference was seen between the two groups in the incidence of tumor calcification or necrosis. No relationship between the level of urinary vanillylmandelic acid (VMA) and the presence of primary tumor uptake of 99mTc-MDP was found. The possible causes for the localization of 99mTc-MDP are discussed.

Topics: Adrenal Gland Neoplasms; Bone and Bones; Calcinosis; Child; Child, Preschool; Diphosphonates; Female; Humans; Infant; Infant, Newborn; Male; Mediastinal Neoplasms; Necrosis; Neuroblastoma; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate; Vanilmandelic Acid