technetium-tc-99m-medronate and Body-Weight

To perform quantitative measurement based on the standardized uptake value (SUV) of Tc-99m methylene diphosphonate (MDP) in the normal pelvis using a single-photon emission tomography (SPECT)/computed tomography (CT) scanner.. This retrospective study was performed on 31 patients with cancer undergoing bone SPECT/CT scans with 99mTc-MDP. SUVmax and SUVmean of the normal pelvis were calculated based on the body weight. SUVmax and SUVmean of the bilateral anterior superior iliac spine, posterior superior iliac spine, facies auricularis ossis ilii, ischial tuberosity, and sacrum were also calculated. Furthermore, the correlation of SUVmax and SUVmean of all parts of pelvis with weight, height, and CT was assessed.. The data for 31 patients (20 women and 11 men; mean age 58.97±9.12 years; age range 37-87 years) were collected. SUVmax and SUVmean changed from 1.65±0.40 to 3.8±1.0 and from 1.15±0.25 to 2.07±0.58, respectively. The coefficient of variation of SUVmax and SUVmean ranged from 0.22 to 0.31. SUVmax and SUVmean had no statistically significant difference between men and women. SUVmax and SUVmean also showed no significant correlation with weight and height. However, part of SUVmax and SUVmean showed a significant correlation with CT. In addition, SUVmax and SUVmean of the bilateral ischial tuberosity showed a significant correlation with CT values.. Determination of the SUV value of the normal pelvis with 99m Tc-MDP SPECT/CT is feasible and highly reproducible. SUVs of the normal pelvis showed a relatively large variability. As a quantitative imaging biomarker, SUVs might require standardization with adequate reference data for the participant to minimize variability.

Topics: Aged; Body Weight; Female; Humans; Male; Middle Aged; Pelvic Neoplasms; Pelvis; Phantoms, Imaging; Retrospective Studies; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Based on the hypothesis that bone calcification is promoted by loading physical pressure, changes in the microstructure of the bone under hyperbaric conditions were analyzed by imaging technology. Hyperbaric exposure was carried out for two weeks at 2 atm (equal to the pressure at a depth of water of 10 m) which was achieved using a mixed gas of helium and oxygen (He:O2 88%:12%) in which the oxygen partial pressure was maintained at constant (PO2: 0.21 bar). In image technological analysis, the growth and development of the bone were evaluated at different stages using Digital Magnification Radiography (DMR) images and based on changes in the X-ray absorption ratio. DMR images after hyperbaric exposure showed calcification in the heads of long bones (humeri, femora, and tibiae) in mice. There were also significant changes in the X-ray absorption ratio in the heads. The accumulation of 99mTc-MDP was higher in all long-bone heads after hyperbaric exposure than before exposure. These results suggest that the hyperbaric environment promotes bone calcification.

Topics: Animals; Atmospheric Pressure; Body Weight; Calcification, Physiologic; Femur; Helium; Humerus; Hyperbaric Oxygenation; Male; Mice; Mice, Inbred Strains; Oxygen; Technetium Tc 99m Medronate; Tibia; Weight-Bearing

Computerized bone scanning (CBS), a technique used to measure quantitative changes in bone scans, is described. Ten patients with histologically proven metastatic carcinoma of the prostate had sequential CBS performed. Good correlation was found between marked improvement in CBS (more than 50% average decrease in counts) and objective responses. Two patients had partial remission with more than 50% average decrease in uptake by prostatic cancer project criteria; both of them had good pain control. Three patients had worsening of their disease by CBS, which correlated with other parameters of disease progression (new lesions in bone survey, loss of weight and poor survival). In those patients with less than 50% average change the correlation is not so clear cut. An increase in percentage of uptake occurs in the first month after beginning of therapy, and no significant change is observed until 3 months. CBS is a technique that allows for objective measurement of quantitative changes in bone uptake, which is potentially useful for the evaluation of response to treatment in patients with metastatic bone disease from carcinoma of the prostate.

Topics: Acid Phosphatase; Aged; Body Weight; Bone and Bones; Bone Neoplasms; Diphosphonates; Humans; Male; Middle Aged; Prospective Studies; Prostatic Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Medronate

Topics: Acne Vulgaris; Adolescent; Arthritis, Rheumatoid; Body Weight; Diphosphonates; Fever; Humans; Male; Radiography; Radionuclide Imaging; Sacroiliac Joint; Syndrome; Technetium; Technetium Tc 99m Medronate