technetium-tc-99m-medronate and Astrocytoma

Ewing's sarcoma is a highly malignant neoplasm of bones which accounts for the 10% of primary bone malignancies. Primary Ewing's sarcoma of skull vault is very rare and constitutes 1-6% of all Ewing's sarcomas. We present a case of a primary and a radiation-induced skull Ewing's sarcoma. The symptoms, neuroimaging findings and the treatment for these cases are reviewed. Both children were operated with favorable outcome.

Topics: Adolescent; Astrocytoma; Brain Neoplasms; Facial Nerve Diseases; Facial Paralysis; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Neoplasms, Radiation-Induced; Particle Accelerators; Petrous Bone; Radiopharmaceuticals; Sarcoma, Ewing; Skull Neoplasms; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

To establish a method for localization and qualitative diagnosis of glioma.. The monoclonal antibody SZ-39 against human glioma was labelled with 131I and injected intravenously into 40 patients with intracranial occupying lesions proved by X-CT. 72 hours after 131I-McAb-SZ39 administration, cranial bone nuclide-imaging agent 99mTc-MDP was injected intravenously, and the patients were examined by SPECT scan with dual nuclide double channel tomography and special software. On radio-immuno-image, the immunocomplex formed by specific conjugation of 131I-McAb-SZ39 with target tissue was red, while the cranial bone incorporated with 99mTc-MDP was green. The location of the immunocomplex area could be identified by the superimposition of the images.. 21 patients with positive targeting diagnosis of glioma showed the accuracy rate checked by SPECT was 81%(17/21) and by X-CT 48% (10/21). Seven patients with negative targeting diagnosis showed the accuracy rate checked by SPECT was 86%(6/7) and by X-CT 14% (1/7). Pathologically, the sensitivity of targeting SPECT to glioma was 94.5%(17/18) and that of X-CT 55%(10/18).. Targeting SPECT examination could be used for localization and qualitative diagnosis of glioma and make up the inadequacy of X-CT in the qualitative diagnosis of atypical incipient and recurrent glioma, meningioma, metastatic carcinoma, and inflammatory lesions of brain.

Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Female; Glioblastoma; Humans; Iodine Radioisotopes; Male; Middle Aged; Radioimmunodetection; Technetium Tc 99m Medronate; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed