technetium-tc-99m-medronate and Angiomatosis

Gorham disease is a rare condition characterized by intraosseous neoplastic proliferation of hemangiomatous tissue with progressive, massive osteolysis. We present a pathologically proved case of Gorham disease that involved the left parietal bone in a 23-year-old man. Imaging studies including conventional radiography of the skull, CT, MR imaging, and Technetium-99 m (Tc-99 m) scintigraphy demonstrated a large skull defect without associated soft tissue mass over the left parietal skull. Contrast enhancement and increased isotope uptake along the margin of the defect were shown at gadolinium-enhanced T1-weighted MR imaging and Tc-99 m methylene diphosphate (Tc-99 m MDP) bone scintigraphy. Pathologic study revealed intraosseous angiomatosis at the periphery of the osteolytic skull lesion.

Topics: Adult; Angiomatosis; Diagnosis, Differential; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Osteolysis; Osteolysis, Essential; Parietal Bone; Radionuclide Imaging; Technetium Tc 99m Medronate; Tomography, X-Ray Computed

Three-phase bone scintigraphy elegantly demonstrates the vascular nature of the expansile, lytic lesions of skeletal angiomatosis and the induced bony changes in the involved areas. Unusual features of the case include its confinement to the hand and rapid progression as shown by serial radiographs.

Topics: Adolescent; Angiomatosis; Bone Neoplasms; Hand; Humans; Male; Radiography; Radionuclide Imaging; Technetium Tc 99m Medronate

The hospital course of a patient with diffuse skeletal hemangiomatosis is presented with reference to the role of radionuclide imaging procedures in the diagnosis and evaluation of this disorder. In addition to static scans of liver, bone, and bone marrow, flow studies using Tc-99m-sulfur colloid and methylene diphosphonate (MDP) were performed.

Topics: Adult; Angiomatosis; Bone Marrow; Bone Neoplasms; Diphosphonates; Humans; Liver; Male; Radionuclide Imaging; Sulfur; Technetium; Technetium Tc 99m Medronate; Technetium Tc 99m Sulfur Colloid