technetium-tc-99m-mebrofenin and Amyloid-Neuropathies--Familial

Early postoperative hepatobiliary scintigraphy after liver transplantation is performed worldwide, but data on its significance for graft function are currently limited.. To examine the correlation between the result of early postoperative hepatobiliary scintigraphy and pre- and postoperative biochemical parameters in liver transplantation (LTx) patients.. Six parameters of hepatobiliary scintigraphy using (99m)Tc mebrofenin were statistically analyzed in 108 LTx patients: 1) half-life of the activity of elimination of mebrofenin from the blood; 2) total clearance of mebrofenin from the blood due to all possible routes; 3) half-life of the activity due to liver uptake; 4) clearance of mebrofenin from the blood due to liver uptake; 5) time to maximal uptake in the liver; and 6) the hepatic extraction fraction (HEF) and biochemical data. Analysis between patients with preoperative normal liver function, familial amyloid polyneuropathy (FAP), and end-stage liver disease (non-FAP) was also performed.. Univariate and multivariate analysis revealed that total bilirubin postoperative day 3 correlated with all three scintigraphic parameters, and peak aspartate aminotransferase and alanine aminotransferase correlated with HEF. The analysis between patients with FAP and non-FAP revealed no significant difference of scintigraphic data between the two groups.. A significant correlation between early postoperative scintigraphic results and biochemical parameters was demonstrated.

Topics: Adolescent; Adult; Aged; Alanine Transaminase; Amyloid Neuropathies, Familial; Aniline Compounds; Aspartate Aminotransferases; Biliary Tract; Bilirubin; Biomarkers; Child; Child, Preschool; Female; Glycine; Humans; Imino Acids; Liver; Liver Diseases; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Organotechnetium Compounds; Postoperative Period; Predictive Value of Tests; Radionuclide Imaging; Retrospective Studies; Time