technetium-tc-99m-lidofenin and Hyperbilirubinemia--Hereditary

In three patients with chronic conjugated hyperbilirubinemia who carried the diagnosis of Rotor syndrome, 99mTc-HIDA cholescintigraphy was performed. In these patients, the liver was either not visualized or it was seen very faintly with slow liver uptake, persistent visualization of the cardiac blood pool and prominent kidney excretion. The present observation emphasizes the contribution of cholescintigraphy in the diagnosis of Rotor syndrome.

Topics: Adolescent; Biliary Tract; Child; Child, Preschool; Humans; Hyperbilirubinemia, Hereditary; Imino Acids; Liver; Male; Organotechnetium Compounds; Radionuclide Imaging; Technetium Tc 99m Lidofenin

99mTc-HIDA cholescintigraphy was performed in 6 patients with Dubin-Johnson syndrome and 1 patient with Rotor syndrome. In the patients with Dubin-Johnson syndrome, the cholescintigrams had a characteristic pattern of delayed visualization or nonvisualization of the gallbladder and bile ducts in the presence of intense, homogeneous, and prolonged visualization of the liver. In the patient with Rotor syndrome, the hepatobiliary system was not visualized at all. It is concluded that 99mTc-HIDA cholescintigraphy may be helpful in the diagnosis of Dubin-Johnson syndrome and Rotor syndrome and in the differential diagnosis between these two conditions.

Topics: Diagnosis, Differential; Gallbladder; Humans; Hyperbilirubinemia, Hereditary; Imino Acids; Jaundice, Chronic Idiopathic; Liver; Radionuclide Imaging; Syndrome; Technetium; Technetium Tc 99m Lidofenin

Topics: Adult; Biliary Tract; Humans; Hyperbilirubinemia, Hereditary; Imino Acids; Iodine Radioisotopes; Jaundice, Chronic Idiopathic; Liver; Male; Organotechnetium Compounds; Radionuclide Imaging; Rose Bengal; Syndrome; Technetium; Technetium Tc 99m Diethyl-iminodiacetic Acid; Technetium Tc 99m Lidofenin