technetium-tc-99m-lidofenin and Hepatitis

Topics: Adult; Bile Ducts; Cholecystitis; Cholelithiasis; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Common Bile Duct Diseases; Cysts; Hepatitis; Humans; Imino Acids; Infant, Newborn; Radionuclide Imaging; Technetium; Technetium Tc 99m Lidofenin; Tomography, X-Ray Computed; Ultrasonography

Topics: Adolescent; Biliary Tract Diseases; Child; Child, Preschool; Female; Hepatitis; Humans; Imino Acids; Male; Organotechnetium Compounds; Radionuclide Imaging; Technetium Tc 99m Lidofenin

The motor activity of the gall bladder was studied using cholescintigraphy with 99m Tc-HIDA in 57 patients with chronic cholecystitis and chronic hepatitis and in 9 controls. A comparative analysis of the curves activity-time based upon the elements of images of the external contour and the entire zone of the gall bladder, made it possible to reveal differences in the type of reaction of the gall bladder to the use of cholagogic stimulators (cholecystokinin i.v. and cholagogic breakfast). A method of the processing of the results made it possible to determine the number of contraction phases of the gall bladder during its emptying as well as the true latent period and the period of primary reactions of the biliferous apparatus after taking a food stimulus.

Topics: Cholagogues and Choleretics; Cholecystitis; Cholecystokinin; Gallbladder; Hepatitis; Humans; Imino Acids; Peristalsis; Radionuclide Imaging; Technetium; Technetium Tc 99m Lidofenin

99mTc-diethyl-HIDA cholescintigraphy was performed on 24 patients with histologically proven liver disease and on 10 normal adult subjects. Liver mass transport of HIDA was interpreted with the aid of a probabilistic model, assuming that the tracer particles undergo mixed random walks with drifts. The radiohepatograms were thus fitted with a gamma-variate function and the fitting parameters were evaluated as estimates of the severity of the disease. These parameters, together with the transit times, were also used to generate parametric images of liver function. The advantages of this approach are discussed and the following conclusions are drawn: (1) The gamma-fit is highly satisfactory with any type of experimental curve (0.98 less than r less than 1). (2) The parameters derived from the gamma-fit make it possible to objectively assess the extent of liver functional impairment. (3) Parametric imaging of the liver mass transport of HIDA is easily implemented, but still more experience is needed to assess its impact on patient care.

Topics: Bile Ducts; Cholestasis; Hepatitis; Humans; Imino Acids; Kinetics; Liver; Liver Cirrhosis; Liver Diseases; Models, Biological; Radionuclide Imaging; Technetium; Technetium Tc 99m Lidofenin

Topics: Chronic Disease; Hepatitis; Humans; Hyperbilirubinemia; Imino Acids; Liver; Liver Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Lidofenin; Time Factors