technetium-tc-99m-lidofenin and Chronic-Disease

Between April 1, 1989, and January 1, 1994, 38 patients with chronic acalculous cholecystitis underwent an advanced (3-puncture) laparoscopic cholecystectomy at our institution. The 30 women and 8 men had a mean age of 39 years (range, 23 to 65 years) and represented 4.5% of our overall gallbladder patient population. In each case, the disease produced typical biliary colic, but no gallstones were visualized on ultrasound examination; cholecystokinin-stimulated cholescintigraphy revealed a dysfunctional gallbladder, as evidenced by an ejection fraction of < or = 35% or nonvisualization or nonemptying of the organ. In all 38 cases, cholecystectomy resulted in the complete relief of symptoms. Although an increasing number of physicians are recommending this operation for acalculous gallbladder disease, it should not be performed on the basis of clinical history alone. Rather, objective criteria confirming the need for surgical intervention should be obtained by means of appropriate preoperative testing, including cholecystokinin-stimulated cholescintigraphy.

Topics: Adult; Aged; Biliary Dyskinesia; Cholecystectomy, Laparoscopic; Cholecystitis; Cholecystokinin; Chronic Disease; Female; Humans; Imino Acids; Male; Middle Aged; Organotechnetium Compounds; Technetium Tc 99m Lidofenin; Ultrasonography

Cholescintigraphy with morphine augmentation is used routinely to expedite the differential diagnosis of acute from chronic cholecystitis. A patient with hepatic dysfunction and an allergy to morphine received intravenous meperidine in conjunction with cholescintigraphy. The gallbladder was not visualized 30 minutes after administration of the drug. However, the activity accumulated in the initial photon deficient gallbladder at 4 hours after meperidine administration (6.5 hours after radiopharmaceutical administration). These findings may be explained in part by prolongation of meperidine bioavailability because of impairment of hepatic function.

Topics: Acute Disease; Cholecystitis; Chronic Disease; Diagnosis, Differential; Drug Hypersensitivity; Gallbladder; Humans; Imino Acids; Male; Meperidine; Middle Aged; Morphine; Organotechnetium Compounds; Radionuclide Imaging; Technetium Tc 99m Lidofenin; Time Factors

The function of the hepatobiliary system was studied on 60 women, undergone inflammatory diseases in the uterus and adnexa. The women of the basic group (n = 60) were divided into two subgroups in accordance with the state of genital organs. The first subgroup (n = 39) included women with residual manifestation of chronic salpingo-oophoritis. The second subgroup (n = 21) included women with tumours and tumour-like processes of genital organs, occurred on the back ground of a continuous inflammatory process. The control group included 10 healthy women. Dynamic scintigraphy of the liver and gallbladder utilizing Tc99 radionuclide with short duration of life, was used to determine the functional state of the liver and gallbladder together with biochemical parameters of blood. The obtained results showed that there were significant changes in hepatobiliary system of women with residual manifestations of chronic salpingo-oophoritis. In women with tumours and tumour-like processes of genitals, occurred on the background of continuous inflammatory process, there were significant disturbances in the engulfing-depurating function of the liver and gallbladder of hypokinetic type.

Topics: Adult; Biliary Tract; Chronic Disease; Endometritis; Female; Humans; Imino Acids; Liver; Middle Aged; Oophoritis; Organotechnetium Compounds; Pelvic Inflammatory Disease; Radionuclide Imaging; Recurrence; Salpingitis; Technetium Tc 99m Lidofenin

We intended to estimate D.G.R. in patients suffering from GU, and CG, comparing them with healthy controls. 70 patients, divided in 3 groups, were studied; Group A (Control): 14 cases, Group B (GU) type I Johnson: 11 cases, type III Johnson: 20 cases; Group C (CG): 25 cases (11 antral and 14 antral and fundic). The following studies were performed in all of them upper digestive tract X-ray and fibro-endoscopy with multiple antral and fundic biopsies. Tc 99 HIDA 2 ml. Cu. I.V. was used as radioactive compound, and in the first hour 0.3 ml Cu. in 100 cc of water was administered orally, so as to confirm gastric topography. All patients were studied for 2 hour. Quantitative assessment of D.G.R. was expressed in % related to the hepatobiliary area. D.G.R. was detected in 7.1% of patients in Group A: 54.5% of GU type I and 70% in GU type III. In antral CG a 72.7% of D.G.R. was observed and in antral and fundic CG a 87.6% was found. The differences were significant in all the cases. D.G.R. MAGNITUDE, expressed as geometric mean, was: for Group A: 0.73%; for Group B: Ulcer type I: 6.26% and type III: 6.26%, for Group C: 6.78% in antral gastritis and 11.41% in antral and fundic gastritis.

Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Duodenogastric Reflux; Female; Gastritis; Humans; Imino Acids; Male; Middle Aged; Organometallic Compounds; Radionuclide Imaging; Stomach Ulcer; Technetium Tc 99m Lidofenin

Topics: Adult; Cholecystectomy; Cholecystitis; Cholelithiasis; Chronic Disease; Humans; Imino Acids; Liver; Organometallic Compounds; Radionuclide Imaging; Technetium Tc 99m Lidofenin

The article describes results of using dynamic hepatobiliary scintigraphy in 43 young patients with chronic calculous cholecystitis. High informative value of the method for diagnosis of morpho-functional changes in the organs of the hepatobiliary system is shown, hyperbilirubinemia included. More than in half of the patients alterations of the absorptive-excretory functions of the liver and motor function of the gallbladder were revealed. Their direct relationship with the duration of the disease and degree of the inflammatory process in the biliary tract is established.

Topics: Adult; Biliary Tract; Cholecystitis; Cholelithiasis; Chronic Disease; Evaluation Studies as Topic; Female; Humans; Imino Acids; Iodipamide; Liver; Male; Radiography; Technetium; Technetium Tc 99m Lidofenin; Tomography, Emission-Computed

During a two year period, 1981 to 1982, 21 of 262 patients undergoing cholecystectomy had acalculous cholecystitis. The majority of these patients had chronic disease, and more than 50 per cent of them were in the older age group and had other chronic medical problems. The signs and symptoms are similar to that of calculous cholecystitis, although the cause is unclear. However, the patient with these complaints deserves thorough evaluation in order to rule out other disorders of the upper part of the gastrointestinal tract, because cholecystectomy for chronic acalculous cholecystitis will relieve the symptoms in more than 80 per cent of the patients. Acalculous cholecystitis is a true organic problem which, if diagnosed accurately, can be effectively treated with cholecystectomy.

Topics: Cholangiography; Cholecystectomy; Cholecystitis; Chronic Disease; Female; Follow-Up Studies; Humans; Imino Acids; Male; Radionuclide Imaging; Technetium; Technetium Tc 99m Lidofenin; Time Factors; Ultrasonography

Topics: Adult; Aged; Biliary Tract; Chronic Disease; Female; Humans; Imino Acids; Liver; Middle Aged; Pancreatic Diseases; Pancreatic Neoplasms; Pancreatitis; Radionuclide Imaging; Recurrence; Technetium; Technetium Tc 99m Lidofenin

Topics: Adult; Aged; Cholecystitis; Cholelithiasis; Chronic Disease; Female; Gallbladder; Humans; Imino Acids; Male; Middle Aged; Radiography; Technetium; Technetium Tc 99m Lidofenin; Tomography, Emission-Computed

Changes in the radiological diagnosis of gallbladder disease are occurring at a remarkable rate. In this symposium, several recognized authorities place the various diagnostic modalities and their interrelation in modern perspective. The present and future roles of oral cholecystography and intravenous cholangiography, the radiological diagnosis of chronic acalculous cholecystitis, and the use of ultrasonography and cholescintigraphy are analyzed.

Topics: Acute Disease; Cholangiography; Cholecystitis; Cholecystography; Cholecystokinin; Chronic Disease; Gallbladder Diseases; Humans; Imino Acids; Radionuclide Imaging; Technetium; Technetium Tc 99m Diethyl-iminodiacetic Acid; Technetium Tc 99m Lidofenin; Tomography, X-Ray Computed; Ultrasonography

Topics: Adult; Biliary Tract; Biliary Tract Diseases; Chronic Disease; Common Bile Duct; Female; Gallbladder; Humans; Imino Acids; Liver; Male; Middle Aged; Radionuclide Imaging; Technetium; Technetium Tc 99m Lidofenin

Topics: Biliary Dyskinesia; Child; Cholecystitis; Chronic Disease; Female; Gallbladder; Humans; Imino Acids; Radionuclide Imaging; Scintillation Counting; Technetium; Technetium Tc 99m Lidofenin

Topics: Chronic Disease; Hepatitis; Humans; Hyperbilirubinemia; Imino Acids; Liver; Liver Neoplasms; Radionuclide Imaging; Technetium; Technetium Tc 99m Lidofenin; Time Factors