technetium-tc-99m-gluconate and Cardiomyopathies

Topics: Animals; Cardiomyopathies; Diphosphates; Dogs; Gluconates; Heart; Organotechnetium Compounds; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Animals; Cardiomyopathies; Dogs; Female; Gluconates; Heart; Humans; Lupus Erythematosus, Systemic; Male; Organotechnetium Compounds; Radionuclide Imaging; Technetium

In 10 dogs experimental cardiomyopathy was produced using high intravenous doses of adrenaline and theophylline. The possibility of scintigraphic detection of this non-ischaemic damage was tested by means of 99mTc-gluconate. In 5 dogs the scintigraphic examination was carried out 4 hrs following the production of the damage. In all 5 cases a marked positivity of the heart scan was observed. The finding was confirmed by the radioactivity of tissue samples from all sections of the heart. In 3 out of 5 dogs the histological examination of the myocardium (PAS and HBFP staining) was positive. In the remaining 5 dogs the scan was performed 24 hrs following the development of the damage. A positive scintigraphic finding was observed in 4 cases, the degree of accumulation being lower than at 4 hrs. The radioactivities of tissue samples were also significantly lower as compared with the 4-hr values. In contrast, the histological findings were markedly positive in all 5 dogs. It follows that 99mTc-gluconate is capable of detecting in addition to infarctions non-ischaemic damages to the myocardium, too. The normalization of the finding is very quick. This experimental finding appears to be of importance in clinical practice.

Topics: Animals; Cardiomyopathies; Dogs; Drug Evaluation, Preclinical; Epinephrine; Gluconates; Heart; Myocardium; Organotechnetium Compounds; Radionuclide Imaging; Technetium; Theophylline; Time Factors

In long-term daunorubicin treated rabbits increased myocardial accumulation of 99Tcm-pyrophosphate and 99Tcm-gluconate of a varying degree were recorded, visible at gamma camera examination in more than half of the animals. Chronic cardiomyopathy morphologically and topographically different from the ischemic myocardial injury was demonstrated in most animals at light microscopic examination. The myocardial abnormalities were classified in qualitative and quantitative scores and compared with the degree of isotope accumulation. The rabbits receiving a large single dose of daunorubicin had slightly increased isotope accumulation in the myocardium but no histopathologic changes.

Topics: Animals; Cardiomyopathies; Daunorubicin; Diphosphates; Drug Administration Schedule; Female; Gluconates; Heart; Male; Myocardium; Organ Size; Organotechnetium Compounds; Rabbits; Radionuclide Imaging; Technetium; Technetium Tc 99m Pyrophosphate