technetium-tc-99m-gluceptate and Kidney-Failure--Chronic

The diagnostic value of renal scintiscans in patients with acute or chronic renal failure has not been emphasized other than for the estimation of renal size. 131I OIH, 67gallium, 99mTcDTPA, glucoheptonate and DMSA all may be valuable in a variety of specific settings. Acute renal failure due to acute tubular necrosis, hepatorenal syndrome, acute interstitial nephritis, cortical necrosis, renal artery embolism, or acute pyelonephritis may be recognized. Data useful in the diagnosis and management of the patient with obstructive or reflux nephropathy may be obtained. Radionuclide studies in patients with chronic renal failure may help make apparent such causes as renal artery stenosis, chronic pyelonephritis or lymphomatous kidney infiltration. Future correlation of scanning results with renal pathology promises to further expand nuclear medicine's utility in the noninvasive diagnosis of renal disease.

Topics: Acute Kidney Injury; Adult; Aged; Embolism; Female; Gallium Radioisotopes; Humans; Iodine Radioisotopes; Iodohippuric Acid; Kidney Failure, Chronic; Kidney Neoplasms; Male; Middle Aged; Nephritis, Interstitial; Organotechnetium Compounds; Pentetic Acid; Pyelonephritis; Radionuclide Imaging; Renal Artery Obstruction; Succimer; Sugar Acids; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Pentetate

Tc-99m cystine has been proved to be a good renal agent in animals. Its clinical evaluation has not been reported. In this study, Tc-99m cystine is used for evaluation of renal function in normal subjects and patients with chronic renal failure as well as in renal transplant patients. The results are compared with similar studies using Tc-99m DTPA and Tc-99m GHA. The clearance values also are compared with I-131 OIH. The results show that Tc-99m cystine has good radiopharmaceutical characteristics suitable for evaluation of both renal function as well as morphology.

Topics: Cystine; Humans; Iodine Radioisotopes; Iodohippuric Acid; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Organotechnetium Compounds; Radioisotope Renography; Sugar Acids; Technetium Tc 99m Pentetate

Tc-99m cystine has been proven to be a good renal agent in animals, but its clinical evaluation has not been reported. In this study, Tc-99m cystine was used for evaluation of renal function in normal subjects and patients with chronic renal failure as well as in renal transplant patients. The results are compared with similar studies that used Tc-99m DTPA and Tc-99m GHA. The clearance values also have been compared with I-131 OIH clearance. The results show that Tc-99m cystine has good radiopharmaceutical characteristics suitable for evaluation of both renal function as well as morphology.

Topics: Cystine; Humans; Iodine Radioisotopes; Iodohippuric Acid; Kidney Failure, Chronic; Kidney Transplantation; Organotechnetium Compounds; Radioisotope Renography; Sugar Acids; Technetium Tc 99m Pentetate

A Tc-99m glucoheptonate renal flow study performed in a patient with chronic renal insufficiency and worsening congestive heart failure demonstrated evidence of massive tricuspid regurgitation, with activity appearing in a markedly dilated inferior vena cava within 4 seconds of the tracer bolus entering the right ventricle. Autopsy subsequently confirmed the scintigraphic findings, demonstrating an incompetent tricuspid valve secondary to immobilization of the posterior leaflet as a result of adhesions from a longstanding right ventricular pacemaker wire.

Topics: Aged; Humans; Kidney Failure, Chronic; Male; Organotechnetium Compounds; Radionuclide Imaging; Renal Circulation; Sugar Acids; Tricuspid Valve Insufficiency

Major advances in nuclear medicine instrumentation and radiopharmaceuticals for renal studies have occurred during the last decade. Current nuclear medicine methodology can be applied for accurate evaluation of renal function and for renal imaging in a wide variety of clinical situations. Total renal function can be estimated from the plasma clearance of agents excreted by glomerular filtration or tubular secretion, and individual function can be estimated by imaging combined with renography. A major area of radionuclide application is in the evaluation of obstructive uropathy. The introduction of diuretic renography and the use of computer-generated regions of interest offer the clinician added useful data which may aid in diagnosis and management. Imaging is of proven value also in trauma, renovascular hypertension, and acute and chronic renal failure. Methods for the evaluation of residual urine, vesicoureteral reflux, and testicular torsion have achieved increasing clinical use. These many procedures assure a meaningful and useful role for the application of nuclear medicine in genitourinary imaging.

Topics: Adult; Female; Humans; Infant; Iodohippuric Acid; Kidney Failure, Chronic; Male; Middle Aged; Organotechnetium Compounds; Pentetic Acid; Radioisotope Renography; Spermatic Cord Torsion; Succimer; Sugar Acids; Technetium; Technetium Tc 99m Dimercaptosuccinic Acid; Technetium Tc 99m Pentetate; Ureteral Obstruction; Urinary Tract Infections; Urologic Diseases; Vesico-Ureteral Reflux

A case is presented illustrating one or more vicarious routes of excretion in other abdominal organs after injection of 99mtechnetium-labeled glucoheptonate for renal imaging. The patient had chronic renal disease, but mechanism of the vicarious excretion is obscure.

Topics: Aged; Female; Humans; Kidney Failure, Chronic; Liver; Male; Middle Aged; Organotechnetium Compounds; Radionuclide Imaging; Spleen; Sugar Acids; Technetium