technetium-tc-99m-exametazime and Near-Drowning

The study investigates the effect of zolpidem (CAS 82626-48-0) on brain injuries and cerebellar diaschisis. Four patients with varied brain injuries, three of them with cerebellar diaschisis, were imaged by 99mTc HMPAO Brain SPECT before and after application of zolpidem. The baseline SPECT before zolpidem showed poor tracer uptake in brain injury areas and cerebellar diaschisis. After zolpidem, cerebral perfusion through brain injury areas improved substantially in three patients and the cerebellar diaschisis was reversed. Observations point to a GABA based phenomenon that occurs in brain injury and diaschisis that is reversible by zolpidem.

Topics: Adult; Brain Injuries; Cerebellar Diseases; Cerebrovascular Circulation; Child, Preschool; Diabetes Mellitus; Humans; Hypnotics and Sedatives; Male; Near Drowning; Persistent Vegetative State; Pyridines; Radiopharmaceuticals; Spinocerebellar Ataxias; Stroke; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon; Zolpidem