technetium-tc-99m-exametazime and Lymphoma--Non-Hodgkin

Topics: Adult; Bone Neoplasms; Humans; Ilium; Leukocytes; Lymphoma, Non-Hodgkin; Male; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Exametazime

Radiolabelled white cell scanning is widely used to detect the presence of infection. We present a case of non-Hodgkin s lymphoma manifesting with signs and symptoms suggestive of infection, in which a technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) white cell scan demonstrated high uptake in lymph nodes involved by lymphoma. Differential cell analysis showed preferential lymphocyte labelling. The classification and management of the disease were changed accordingly. Our findings suggest that a future role for 99mTc-HMPAO labelled white cells in the assessment of disease activity of lymphoma should be investigated.

Topics: Diagnosis, Differential; Humans; Infections; Leukocytes; Lymph Nodes; Lymphoma, Non-Hodgkin; Male; Middle Aged; Organotechnetium Compounds; Oximes; Radionuclide Imaging; Technetium Tc 99m Exametazime

A total of 343 leucocyte scans labelled with technetium-99m hexamethylpropylene amine oxime were reviewed that had been performed in 338 patients suspected of having abdominal infection or inflammation. There was uptake by malignant abdominal tumours in 10 cases (2.9%), which represents 62.5% of known malignancies at the time of the scintigram. Accumulation was seen in 8 patients with adenocarcinoma of the colon associated with a secondary infection in the tumour or pericolic inflammation. A large tumour that had spread beyond the bowel wall was related to a positive scintigram. Accumulation was also found twice in a malignant fibrous histiocytoma in which bleeding and an inflammatory reaction to necrosis were probably responsible for the uptake. The relevant treatment was delayed for 2 weeks-2 months in 4 patients with adenocarcinoma of the colon in whom the positive uptake was regarded as confirmation of the clinically suspected acute diverticulitis.

Topics: Abdominal Neoplasms; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Apudoma; Female; Histiocytoma, Benign Fibrous; Humans; Leukocytes; Lymphoma, Non-Hodgkin; Male; Middle Aged; Organotechnetium Compounds; Oximes; Radionuclide Imaging; Retrospective Studies; Technetium Tc 99m Exametazime

Topics: Chromosome Aberrations; Humans; Indium Radioisotopes; Isotope Labeling; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Lymphoma, Non-Hodgkin; Organometallic Compounds; Organotechnetium Compounds; Oximes; Technetium Tc 99m Exametazime; Tropolone