technetium-tc-99m-exametazime and Heart-Diseases

Topics: Aged; Cerebral Cortex; Embolism; Heart Diseases; Humans; Hyperemia; Ischemic Attack, Transient; Male; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon

A left ventricular thrombosis post acute myocardial infarction was detected with Tc-99m HMPAO labeled platelet imaging. The left ventricular thrombosis was already detected on early scans, which allowed for a precise diagnosis during the first 6 hours of the study.

Topics: Aged; Blood Platelets; Heart Diseases; Heart Ventricles; Humans; Male; Myocardial Infarction; Organotechnetium Compounds; Oximes; Radionuclide Imaging; Technetium Tc 99m Exametazime; Thrombosis

Thirty-seven children (11 girls, 26 boys; aged 2.8 +/- 2.2 years) with Kawasaki disease (KD) were included in the study. The biventricular functions were evaluated by equilibrium multigated blood pooling ventriculography (EMBPV) and the severity of carditis was decided by Tc-hexamethylpropyleneamine oxime (HMPAO) labelled white blood cell (WBC) heart scans (Tc-WBC). The results showed that 43% (16/37) of the KD cases with the severe carditis by Tc-WBC had the worst left ventricular ejection fraction (LVEF) (55.4 +/- 15.6%) and right ventricular ejection fraction (RVEF) (43.7 +/- 12.2%) by EMBPV; 24% (9/37) of the cases with the mild carditis had the best LVEF (63.5% +/- 8.2%) and RVEF (53.7% +/- 11.2%); the remaining 32% (12/37) had moderately severe carditis and biventricular function (LVEF: 58.2 +/- 17.2% and RVEF: 46.9 +/- 19.5%). Because Tc-WBC cannot only detect the severity of carditis but also predict impairment of ventricular function accurately, the choice of Tc-WBC should be preferable for KD-a common inflammatory cardiovascular disease in children.

Topics: Child; Child, Preschool; Female; Gated Blood-Pool Imaging; Heart Diseases; Humans; Infant; Inflammation; Leukocytes; Male; Mucocutaneous Lymph Node Syndrome; Organotechnetium Compounds; Oximes; Technetium Tc 99m Exametazime; Ventricular Function

Myocardial imaging with 99Tcm-hexamethylpropylene amineoxime (HMPAO)-labelled white blood cells (Tc-WBC) was used to detect carditis and differentiate rheumatic fever (RF) and inactive rheumatic heart disease (IRHD). Ten cases of RF and 15 cases of IRHD were studied, and the results revealed 60% (6/10) of the cases of RF with carditis, but none of the cases (0/15) of IRHD with carditis. There was significant difference (P less than 0.05, by Fisher's test) between RF and IRHD. In our preliminary conclusion, Tc-WBC heart scanning may be a noninvasive method for evaluating the existence of carditis in cases of RHD and in the differentiation of RF and IRHD.

Topics: Adolescent; Child; Child, Preschool; Diagnosis, Differential; Female; Heart Diseases; Humans; Inflammation; Leukocytes; Male; Organotechnetium Compounds; Oximes; Radionuclide Imaging; Rheumatic Fever; Rheumatic Heart Disease; Technetium Tc 99m Exametazime