technetium-tc-99m-exametazime and Fever

Hyperthermia can be the result of many causes such as environmental conditions, brain tumors and infectious diseases. Since hyperthermia is very common, its role in causing stroke through a decrease in cerebral blood flow needed further emphasis. The aim of this study was to record cerebral blood flow in vitro by using isolated rabbit carotid artery strips and in-vivo using radioactive isotope scanning during temperature elevation. The recording of isometric tension in rabbit carotid artery strips in organ baths, and the scintigraphic cerebral imaging of technetium-99m-hexamethyl-propyleneamineoxime (99mTc-HMPAO) using Gamma camera, were acquired at control and higher body temperature by 4 degrees C. Blood pressure was measured through femoral artery and cerebral blood flow was measured through carotid artery. Elevating temperature by 4 degrees C induced reproducible contraction. During hyperthermia, the carotid artery contraction leads to a decrease in cerebral blood flow although the blood pressure did not decrease. The uptake of 99mTc-HMPAO in the brain was significantly reduced. This decrease in cerebral perfusion is regionally dependent, which is more in the frontal area, the cerebral hemispheres than the cerebellum. The decrease was 36+/-3, 37+/-2, 22+/-2%, respectively. Hyperthermia causes carotid artery contraction leading to decrease in cerebral blood flow, which was confirmed by 99mTc-HMPAO images. The decrease is regionally dependent. Since the blood pressure did not decrease by heating, the reduction in cerebral perfusion is mainly due to carotid contraction. The applied neck cooling may be considered as a promising therapeutic strategy for the hyperthermic patient to avoid brain damage. This can be achieved by external application of an ice-water-perfused neck collar.

Topics: Animals; Blood Pressure; Brain; Carotid Arteries; Cerebrovascular Circulation; Fever; Hypothermia, Induced; Male; Neck; Rabbits; Radionuclide Imaging; Radiopharmaceuticals; Regional Blood Flow; Stroke; Technetium Tc 99m Exametazime; Vasoconstriction

Topics: Acute Disease; Aged; Anti-Bacterial Agents; Diagnosis, Differential; Fever; Humans; Male; Organotechnetium Compounds; Oximes; Pyelonephritis; Radionuclide Imaging; Technetium Tc 99m Exametazime; Tomography, X-Ray Computed

Topics: Abdominal Pain; Adult; Female; Fever; Humans; Leukocytes; Organotechnetium Compounds; Oximes; Radionuclide Imaging; Technetium Tc 99m Exametazime; Urinary Retention