technetium-tc-99m-exametazime and Eosinophilia

The authors describe the variability of Tc-99m exametazime-labeled leukocyte distribution as a function of the relative frequency of white cell types in the labeled blood.. A 76-year-old man who was hospitalized with fever and possible postoperative osteomyelitis underwent scintigraphic imaging with Tc-99m exametazime-labeled leukocytes.. The white cell scan excluded any discrete focus of infection and revealed diffuse involvement of the lymph nodes and skin. The pathologic diagnosis was angioimmunoblastic T-cell lymphoma. The atypical infiltrates seen on the white cell scan can be explained by the severe eosinophilic blood count on the day of leukocyte labeling (total leukocyte count: 8,100 cells/microl with 63% neutrophils, 8.9% lymphocytes, and 22.2% eosinophils).. In the labeling of the leukocyte moiety, a higher presence of any leukocyte subpopulation will modify the biodistribution and thus the image interpretation.

Topics: Aged; Diagnosis, Differential; Eosinophilia; Fever of Unknown Origin; Humans; Knee Prosthesis; Leukocytes; Lymphoma, T-Cell; Male; Prosthesis-Related Infections; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Exametazime; Whole-Body Counting

White blood cell (WBC) 99mTc-hexamethylpropyleneamineoxime (HMPAO) scintigraphy was performed in a patient with eosinophilic gastroenteritis. WBC accumulation was detected in the terminal ileum to descending colon, and pathological studies demonstrated eosinophilic infiltration at the same region. 99mTc-HMPAO-WBC scintigraphy was proved to be a useful tool for the detection of eosinophilic infiltration in eosinophilic gastroenteritis.

Topics: Adult; Diagnosis, Differential; Eosinophilia; Gastroenteritis; Humans; Leukocytes; Male; Melena; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Exametazime