technetium-tc-99m-ethylenedicysteine and Parkinson-Disease

To investigate the regional cerebral perfusion in patients with idiopathic REM behavior disorder (RBD) in order to establish the topography of networks involved.. We performed cerebral blood flow evaluation using (99m)Tc-Ethylene Cysteinate Dimer (ECD) SPECT on eight patients with polysomnographically confirmed RBD and nine age-matched controls. Comparisons were made using SPM2.. We found increased perfusion in the pons and putamen bilaterally and in the right hippocampus. In addition, we observed a decreased perfusion in frontal (Brodmann area [BA] 4, 6, 10, 43, 44, 47 bilaterally and left BA 9, 46) and temporo-parietal (BA 13, 22, 43 bilaterally and left BA 7, 19, 20, 21, 39, 40, 41, 42) cortices.. Perfusional abnormalities in patients with REM behavior disorder were located in the brainstem, striatum, and cortex. These abnormalities are consistent with the anatomic metabolic profile of Parkinson disease.

Topics: Aged; Brain; Brain Stem; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Corpus Striatum; Cysteine; Female; Humans; Male; Middle Aged; Neurodegenerative Diseases; Organotechnetium Compounds; Parkinson Disease; Polysomnography; Predictive Value of Tests; Prognosis; REM Sleep Behavior Disorder; Tomography, Emission-Computed, Single-Photon

The correlation between regional cerebral blood flow (rCBF) and intelligence quotient (IQ) score was investigated in patients with Parkinson's disease (PD) without severe dementia. We analyzed the (9mTc-ethyl cysteinate dimer single-photon emission computed tomography quantitative images and Revised Wechsler Adult Intelligence Scale scores of 44 PD patients using statistical parametric mapping. Verbal IQ positively correlated with rCBF in the right ventral striatum and the bilateral prefrontal cortex, performance IQ positively correlated with rCBF in the right operculum, insula and the left middle temporal gyrus, and full-scale IQ positively correlated with rCBF in the right operculum, insula and the ventral striatum. The identified areas may be functionally related to mild to moderate cognitive impairment in patients with PD.

Topics: Aged; Brain; Brain Mapping; Cerebrovascular Circulation; Cysteine; Female; Functional Laterality; Humans; Image Interpretation, Computer-Assisted; Intelligence; Intelligence Tests; Male; Middle Aged; Neuropsychological Tests; Organotechnetium Compounds; Parkinson Disease; Regional Blood Flow; Tomography, Emission-Computed, Single-Photon