technetium-tc-99m-disofenin and Respiratory-Distress-Syndrome

A retrospective review was made of all radionuclide hepatobiliary studies performed in a major trauma center over a 27-month period and correlated with the patients' clinical course. In a population of 42 patients (27 of whom were on total parenteral nutrition [TPN]) who had severe intercurrent illness (primarily trauma), and an additional 18 patients who had hepatocellular dysfunction, hepatobiliary imaging confirmed a patent cystic duct in 43 of 60 patients (72%). Fourteen of these 43 patients (33%) had gallbladder visualization at later than one hour after radiotracer administration, and seven of these 14 required imaging from four to 24 hours. Of 17 patients who had nonvisualization of the gallbladder, four had surgically proved acute cholecystitis. Images of nine of the remaining 13 patients with gallbladder nonvisualization were not obtained for 24 hours. The presence of gallstones, wall thickening, or sludge on sonograms did not correlate with cystic duct patency, and was not specific for acute cholecystitis. Though gallbladder function is compromised in the population with severe intercurrent disease, radionuclide hepatobiliary imaging is still valuable; it can confirm a patent cystic duct in at least 72% of patients if routine imaging is continued for up to 24 hours.

Topics: Acute Disease; Cholecystitis; Diagnosis, Differential; Diagnostic Tests, Routine; Gallbladder; Hepatitis, Alcoholic; Hepatitis, Chronic; Humans; Imino Acids; Intestine, Small; Liver; Organotechnetium Compounds; Parenteral Nutrition, Total; Radionuclide Imaging; Respiratory Distress Syndrome; Retrospective Studies; Sincalide; Technetium; Technetium Tc 99m Disofenin; Time Factors; Ultrasonography; Wounds and Injuries