technetium-tc-99m-disofenin and Purpura--Thrombocytopenic--Idiopathic

ITP (idiopathic thrombocytopenic purpura) causes rapid sequestration and destruction of thrombocytes by the spleen, liver, bone marrow, and reticuloendothelial elements of other organs. The usefulness of multiple radionuclide functional imaging procedures in the management of a 34-year-old woman with chronic ITP, two splenectomies (removal of the initial spleen and then a hypertrophied accessory spleen), and the failure of chemotherapy to control her thrombocytopenia, are discussed. A combination of In-111 oxine autologous platelet imaging, liver/spleen imaging, disofenin (liver/gallbladder) imaging, and glucoheptonate renal imaging demonstrated that her platelets were being sequestered by a markedly enlarged left hepatic lobe extending to the left lateral wall, with a small amount in the kidneys and lungs, and that there was no second accessory spleen.

Topics: Adult; Female; Humans; Imino Acids; Kidney; Liver; Organometallic Compounds; Organotechnetium Compounds; Oxyquinoline; Purpura, Thrombocytopenic, Idiopathic; Radionuclide Imaging; Spleen; Sugar Acids; Technetium Tc 99m Disofenin