technetium-tc-99m-bicisate and Migraine-Disorders

Topics: Adult; Brain; Cerebrovascular Circulation; Cysteine; Humans; Male; Migraine Disorders; Organotechnetium Compounds; Tomography, Emission-Computed, Single-Photon

Single photon emission computed tomography (SPECT) was performed 3 times during attacks and performed 4 times during postictal periods on a case of alternating hemiplegia of childhood. Hyperperfusion of the corresponding hemisphere to hemiparesis was suggested by asymmetric increase RI uptake during the ictal scans, whereas interictal scans showed symmetric topography of cerebral blood flow. Manifestations except hemiplegia included loss of consciousness and vomiting. These manifestations and ictal SPECT findings are the same evidence as hemiplegic migraine. It suggests that these two disorders have a similar pathophysiology. There are two interesting findings regarding this patient. The first finding is magnetic resonance imaging showed progressive cerebellar atrophy. Second finding is interictal SPECT showed a progressive decrease of cerebral perfusion, especially in cerebellar hemispheres. These two findings suggest alternating hemiplegia of childhood may be a chronic progressive disorder.

Topics: Atrophy; Cerebellum; Child; Cysteine; Electroencephalography; Hemiplegia; Humans; Iodine Radioisotopes; Iofetamine; Magnetic Resonance Imaging; Male; Migraine Disorders; Organotechnetium Compounds; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon

The present study was designed to examine the effect of sumatriptan on regional cerebral blood flow (CBF) during migraine headache. Nine cases were examined by 99mTc-ECD background subtraction method for the absolute value measurement of regional CBF before and after sumatriptan injection. rCBF except for occipital and perioccipital lobes, were increased 10-20% during migraine headache and significant decreases were observed by sumatriptan injection. Two cases of nine had transiently increased systemic blood pressure and cardiac pulse rate, however, all cases improved migraine headache after injection of sumatriptan.

Topics: Adolescent; Adult; Brain; Cerebrovascular Circulation; Cysteine; Humans; Middle Aged; Migraine Disorders; Organotechnetium Compounds; Radiopharmaceuticals; Serotonin Receptor Agonists; Sumatriptan; Tomography, Emission-Computed, Single-Photon

Topics: Adult; Brain; Brain Ischemia; Cysteine; Dominance, Cerebral; Female; Humans; Migraine Disorders; Organotechnetium Compounds; Regional Blood Flow; Tomography, Emission-Computed, Single-Photon

Topics: Adolescent; Brain; Cysteine; Humans; Migraine Disorders; Organotechnetium Compounds; Tomography, Emission-Computed, Single-Photon