technetium-tc-99m-bicisate and Hemiplegia

Single photon emission computed tomography (SPECT) was performed 3 times during attacks and performed 4 times during postictal periods on a case of alternating hemiplegia of childhood. Hyperperfusion of the corresponding hemisphere to hemiparesis was suggested by asymmetric increase RI uptake during the ictal scans, whereas interictal scans showed symmetric topography of cerebral blood flow. Manifestations except hemiplegia included loss of consciousness and vomiting. These manifestations and ictal SPECT findings are the same evidence as hemiplegic migraine. It suggests that these two disorders have a similar pathophysiology. There are two interesting findings regarding this patient. The first finding is magnetic resonance imaging showed progressive cerebellar atrophy. Second finding is interictal SPECT showed a progressive decrease of cerebral perfusion, especially in cerebellar hemispheres. These two findings suggest alternating hemiplegia of childhood may be a chronic progressive disorder.

Topics: Atrophy; Cerebellum; Child; Cysteine; Electroencephalography; Hemiplegia; Humans; Iodine Radioisotopes; Iofetamine; Magnetic Resonance Imaging; Male; Migraine Disorders; Organotechnetium Compounds; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon