td-5108 and Guillain-Barre-Syndrome

Acute colonic pseudo-obstruction is characterized by symptoms, signs and radiologic appearance of large bowel obstruction in the absence of a true mechanical obstruction. Several pharmacologic treatments have been proposed. We present a case of a patient with Guillain-Barré syndrome complicated by acute colonic pseudo-obstruction, who had a clinical response to tegaserod, a partial 5-hydroxytryptamine type-4 agonist. 5-Hydroxytryptamine type 4 agonists may be an option in the treatment of acute colonic pseudo-obstruction.

Topics: Acute Disease; Colonic Pseudo-Obstruction; Drug Partial Agonism; Guillain-Barre Syndrome; Humans; Indoles; Male; Middle Aged; Serotonin 5-HT4 Receptor Agonists