tcv-309 and Burns

tcv-309 has been researched along with Burns* in 1 studies

Other Studies

1 other study(ies) available for tcv-309 and Burns

ArticleYear
Effects of a platelet activating factor antagonist on oedema formation following burns.
    Burns : journal of the International Society for Burn Injuries, 1993, Volume: 19, Issue:3

    Deep dermal burns covering 30 per cent of the total body surface area were prepared by immersing the backs of rabbits in hot water at 80 degrees C for 20 s, to determine whether platelet activating factor (PAF) was involved in the onset of oedema following burns and to evaluate the effect of TCV-309, a potent PAF antagonist. The PAF antagonist, which was infused soon after the burn, blocked oedema formation in the wound and significantly (P < 0.001) inhibited PAF increase (P < 0.05) in the damaged tissue in a dose-dependent manner. This was confirmed by immunohistochemistry. In contrast, the superoxide dismutase content in the group treated with a high dose of TCV-309 was significantly (P < 0.01) higher than that of the control group. These findings suggest that administration of large doses of a PAF antagonist immediately after injury prevents oedema of burn wounds and the subsequent onset of burn shock by suppressing PAF and superoxide radical formation.

    Topics: Animals; Body Water; Burns; Edema; Isoquinolines; Platelet Activating Factor; Pyridinium Compounds; Rabbits; Skin; Superoxide Dismutase; Tetrahydroisoquinolines

1993