tbc-11251 has been researched along with Chemical and Drug Induced Liver Injury in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Catalá-López, F; de la Fuente Honrubia, C; Macías Saint-Gerons, D; Montero Corominas, D | 1 |
| Andersson, LC; Bergare, J; Billger, M; Eakins, JA; Elebring, M; Elmore, CS; Foster, AJ; Kenna, JG; Stahl, SH; Thompson, RA | 1 |
| Golpon, H; Hoeper, MM; Olsson, KM; Schneider, A | 1 |
| Hoeper, MM | 1 |
| Gaine, SP; Kelleher, B; Lavelle, A; Lawler, G; Mulligan, N; Murphy, DM; Sugrue, R | 1 |
| Corris, PA; Langleben, D | 1 |
| Galiè, N; Gibbs, JS; Hoeper, MM; Simonneau, G | 1 |
| Fisher, AJ; Johnson, MK; Kirkham, N; Lee, WT; Lordan, JL; Peacock, AJ | 1 |
| Galiè, N; Gibbs, R; Hoeper, MM; Simon, J; Simonneau, G | 1 |
2 review(s) available for tbc-11251 and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Hepatotoxicity in patients treated with endothelin receptor antagonists: systematic review and meta-analysis of randomized clinical trials].
Topics: Antihypertensive Agents; Biomarkers; Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension; Isoxazoles; Phenylpropionates; Pyridazines; Randomized Controlled Trials as Topic; Safety-Based Drug Withdrawals; Sulfonamides; Thiophenes; Transaminases | 2014 |
10 other study(ies) available for tbc-11251 and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Bosentan; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Epithelial Cells; Hepatocytes; Humans; Isoxazoles; Mitochondria; Molecular Structure; Oxygen Consumption; Phenylpropionates; Pyridazines; Sulfonamides; Thiophenes | 2015 |
Severe hepatitis associated with sitaxentan and response to glucocorticoid therapy.
Topics: Chemical and Drug Induced Liver Injury; Eisenmenger Complex; Endothelin Receptor Antagonists; Female; Glucocorticoids; Humans; Isoxazoles; Liver Function Tests; Thiophenes; Young Adult | 2009 |
Liver toxicity: the Achilles' heel of endothelin receptor antagonist therapy?
Topics: Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Isoxazoles; Thiophenes | 2009 |
Sitaxentan-induced hepatic failure in two patients with pulmonary arterial hypertension.
Topics: Aged; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Male; Middle Aged; Thiophenes | 2009 |
The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension.
Topics: Bosentan; Chemical and Drug Induced Liver Injury; Endothelin Receptor Antagonists; Humans; Hypertension, Pulmonary; Isoxazoles; Liver; Phenotype; Receptors, Endothelin; Sulfonamides; Thiophenes | 2010 |
Liver toxicity of sitaxentan in pulmonary arterial hypertension.
Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Failure; Practice Guidelines as Topic; Thiophenes | 2011 |
Sitaxentan-related acute liver failure in a patient with pulmonary arterial hypertension.
Topics: Chemical and Drug Induced Liver Injury; Contraindications; Endothelin A Receptor Antagonists; Familial Primary Pulmonary Hypertension; Fatal Outcome; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Jaundice; Liver Failure, Acute; Piperazines; Purines; Sildenafil Citrate; Sulfones; Thiophenes; Vasodilator Agents; Young Adult | 2011 |
Liver toxicity of sitaxentan in pulmonary arterial hypertension.
Topics: Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Early Termination of Clinical Trials; Endothelin Receptor Antagonists; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Isoxazoles; Safety-Based Drug Withdrawals; Thiophenes | 2011 |