tazarotene has been researched along with Skin Aging in 22 studies
tazarotene: a topical acetylenic retinoid; a topical kerytolytic
tazarotene : The ethyl ester of tazarotenic acid. A prodrug for tazarotenic acid, it is used for the treatment of psoriasis, acne, and sun-damaged skin.
Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tazarotene is a pro-drug of tazarotenic acid, a receptor-selective retinoid, which has shown efficacy in the treatment of these disorders." | 6.41 | Topical tazarotene therapy for psoriasis, acne vulgaris, and photoaging. ( Guenther, LC, 2002) |
| "Patients with facial mottled hyperpigmentation of at least moderate severity and an overall integrated assessment of photodamage score of at least moderate applied tazarotene 0." | 5.12 | Tazarotene versus tazarotene plus hydroquinone in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized study. ( Draelos, Z; Horwitz, S; Lowe, N; Menter, A; Tanghetti, E, 2006) |
| " All significant between-group differences in efficacy measures were in favor of tazarotene - for fine wrinkling at the study endpoint and, at earlier timepoints, for treatment success (> or =50% global improvement), and the overall integrated assessment of photodamage, mottled hyperpigmentation, and coarse wrinkling." | 5.11 | Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized, parallel-group study. ( Gifford, M; Goldman, M; Kang, S; Lowe, N; Poulin, Y; Rosenzweig, H; Tanghetti, E; Tse, Y; Yamauchi, P, 2004) |
| "In this multicentre, double-blind, randomized, vehicle-controlled study, 50 patients with photodamaged facial skin (at least mild fine wrinkling and mottled hyperpigmentation, with at least one of these being moderate) were randomized to apply tazarotene 0." | 5.11 | Histological effects of tazarotene 0.1% cream vs. vehicle on photodamaged skin: a 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin. ( Holland, JM; Kaidbey, K; Lim, J; Loven, KH; Machtinger, LA; Parizadeh, DD; Rist, TE; Sefton, J; Walker, PS; Wilson, DC, 2004) |
| "A total of 568 patients with at least moderate fine wrinkling or mottled hyperpigmentation applied tazarotene 0." | 5.11 | A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage. ( Gibson, JR; Kang, S; Krueger, GG; Lew-Kaya, D; Sefton, J; Tanghetti, EA; Walker, PS, 2005) |
| "Tazarotene cream and tretinoin cream significantly improved mottled hyperpigmentation and fine wrinkles." | 5.09 | Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily f ( Bhawan, J; Gibson, JR; Kang, S; Lew-Kaya, DA; Leyden, JJ; Lowe, NJ; Matsumoto, RM; Ortonne, JP; Phillips, TJ; Sefton, J; Walker, PS; Weinstein, GD, 2001) |
| "To review a decade of experience using tazarotene as a monotherapy or as combination therapy for approved and other indications: acne, psoriasis, photoaging, basal cell carcinomas and various keratinization disorders." | 4.85 | Efficacy and safety of topical tazarotene: a review. ( Cox, K; Duvic, M; Talpur, R, 2009) |
| " A dose-response relationship was evident for both effectiveness and skin irritation." | 2.43 | Interventions for photodamaged skin. ( Brooke, RC; Griffiths, CE; Hollis, S; Samuel, M, 2005) |
| "Although retinoids show promise in the treatment of skin aging, irritant reactions such as burning, scaling or dermatitis associated with retinoid therapy limit their acceptance by patients." | 2.43 | Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. ( Date, A; Korting, HC; Mukherjee, S; Patravale, V; Roeder, A; Weindl, G, 2006) |
| "Tazarotene is a pro-drug of tazarotenic acid, a receptor-selective retinoid, which has shown efficacy in the treatment of these disorders." | 2.41 | Topical tazarotene therapy for psoriasis, acne vulgaris, and photoaging. ( Guenther, LC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 20 (90.91) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Samuel, M | 6 |
| Brooke, R | 4 |
| Hollis, S | 2 |
| Griffiths, CE | 3 |
| Liu, P | 1 |
| Tan, SS | 1 |
| Wang, QY | 1 |
| Wang, YX | 1 |
| Talpur, R | 1 |
| Cox, K | 1 |
| Duvic, M | 1 |
| Darlenski, R | 1 |
| Surber, C | 1 |
| Fluhr, JW | 1 |
| Phillips, TJ | 3 |
| Gottlieb, AB | 1 |
| Leyden, JJ | 2 |
| Lowe, NJ | 2 |
| Lew-Kaya, DA | 2 |
| Sefton, J | 5 |
| Walker, PS | 4 |
| Gibson, JR | 4 |
| Epstein, E | 1 |
| Lowe, N | 2 |
| Gifford, M | 1 |
| Tanghetti, E | 2 |
| Poulin, Y | 1 |
| Goldman, M | 1 |
| Tse, Y | 1 |
| Yamauchi, P | 1 |
| Rosenzweig, H | 1 |
| Kang, S | 3 |
| Stern, RS | 1 |
| Griffiths, C | 3 |
| Machtinger, LA | 1 |
| Kaidbey, K | 1 |
| Lim, J | 1 |
| Loven, KH | 1 |
| Rist, TE | 1 |
| Wilson, DC | 1 |
| Parizadeh, DD | 1 |
| Holland, JM | 1 |
| Brooke, RC | 1 |
| Krueger, GG | 1 |
| Tanghetti, EA | 1 |
| Lew-Kaya, D | 1 |
| Hamerlynck, JV | 1 |
| Middeldorp, S | 1 |
| Scholten, RJ | 1 |
| Horwitz, S | 1 |
| Draelos, Z | 1 |
| Menter, A | 1 |
| Mukherjee, S | 1 |
| Date, A | 1 |
| Patravale, V | 1 |
| Korting, HC | 1 |
| Roeder, A | 1 |
| Weindl, G | 1 |
| Ogden, S | 1 |
| Kligman, AM | 1 |
| Kopper, SC | 1 |
| Lue, JC | 1 |
| Ortonne, JP | 1 |
| Weinstein, GD | 1 |
| Bhawan, J | 1 |
| Matsumoto, RM | 1 |
| Guenther, LC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Safety and Efficacy of Tazarotene 0.1% Plus Clindamycin 1% Gel vs. Adapalene 0.1% Plus Clindamycin 1% Gel in the Treatment of Facial Acne Vulgaris: A Randomized Controlled Trial[NCT02721173] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Microneedling Versus Topical Tazarotene 0.1% Gel for the Treatment of Atrophic Post Acne Scarring - a Randomized Controlled Study[NCT03170596] | 36 participants (Actual) | Interventional | 2017-06-02 | Completed | |||
| The Role of Red Flavonoid in Photoaging[NCT05854628] | 0 participants (Actual) | Interventional | 2023-10-31 | Withdrawn (stopped due to We decided not to proceed further to enroll patients.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for tazarotene and Skin Aging
| Article | Year |
|---|---|
WITHDRAWN: Interventions for photodamaged skin.
Topics: Administration, Cutaneous; Dermatologic Agents; Humans; Isotretinoin; Keratosis; Laser Therapy; Nico | 2015 |
Efficacy and safety of topical tazarotene: a review.
Topics: Acne Vulgaris; Administration, Cutaneous; Animals; Carcinoma, Basal Cell; Dermatologic Agents; Human | 2009 |
Topical retinoids in the management of photodamaged skin: from theory to evidence-based practical approach.
Topics: Administration, Topical; Dermatologic Agents; Evidence-Based Medicine; Humans; Isotretinoin; Nicotin | 2010 |
Wrinkles.
Topics: Antioxidants; Dermabrasion; Dermatologic Agents; Humans; Isotretinoin; Laser Therapy; Nicotinic Acid | 2003 |
Interventions for photodamaged skin.
Topics: Administration, Cutaneous; Dermatologic Agents; Humans; Isotretinoin; Keratosis; Laser Therapy; Nico | 2005 |
Wrinkles.
Topics: Ascorbic Acid; Dermabrasion; Humans; Isotretinoin; Laser Therapy; Nicotinic Acids; Skin Aging; Sunsc | 2004 |
[From the Cochrane Library: Improvement of photodamaged skin with retinoid creams and not with other local treatments].
Topics: Administration, Cutaneous; Dermatologic Agents; Dose-Response Relationship, Drug; Humans; Nicotinic | 2006 |
Wrinkles.
Topics: Dermabrasion; Humans; Isotretinoin; Laser Therapy; Nicotinic Acids; Skin Aging; Sunscreening Agents; | 2005 |
Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety.
Topics: Adapalene; Dermatologic Agents; Dermis; Epidermis; Humans; Naphthalenes; Nicotinic Acids; Retinaldeh | 2006 |
A review of tazarotene in the treatment of photodamaged skin.
Topics: Drug Therapy, Combination; Humans; Keratolytic Agents; Nicotinic Acids; Retinoids; Skin Aging; Treat | 2008 |
Topical tazarotene therapy for psoriasis, acne vulgaris, and photoaging.
Topics: Acne Vulgaris; Administration, Topical; Humans; Nicotinic Acids; Psoriasis; Retinoids; Skin Aging | 2002 |
8 trials available for tazarotene and Skin Aging
| Article | Year |
|---|---|
Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Dermatologic Agents; Dose-Response Relation | 2002 |
Tazarotene 0.1% cream for the treatment of photodamage.
Topics: Administration, Topical; Adult; Aged; Dermatologic Agents; Double-Blind Method; Female; Humans; Male | 2004 |
Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized, parallel-group study.
Topics: Administration, Topical; Dermatologic Agents; Double-Blind Method; Emollients; Face; Female; Humans; | 2004 |
Histological effects of tazarotene 0.1% cream vs. vehicle on photodamaged skin: a 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin.
Topics: Adult; Aged; Double-Blind Method; Facial Dermatoses; Female; Humans; Hyperpigmentation; Keratinocyte | 2004 |
A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage.
Topics: Adult; Aged; Aged, 80 and over; Dermatologic Agents; Double-Blind Method; Facial Dermatoses; Female; | 2005 |
Tazarotene versus tazarotene plus hydroquinone in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized study.
Topics: Administration, Topical; Chi-Square Distribution; Dermatologic Agents; Double-Blind Method; Female; | 2006 |
Photodamage pilot study: a double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel.
Topics: Aged; Dermatologic Agents; Double-Blind Method; Female; Gels; Humans; Middle Aged; Nicotinic Acids; | 2000 |
Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily f
Topics: Administration, Cutaneous; Adult; Dermatologic Agents; Dose-Response Relationship, Drug; Double-Blin | 2001 |
3 other studies available for tazarotene and Skin Aging
| Article | Year |
|---|---|
[Effects of all-trans retinioic acid and tazarotene on MMP-1 and TIMP-1 expression in cultured human fibroblasts after heat shock].
Topics: Cells, Cultured; Fibroblasts; Heat-Shock Response; Humans; Matrix Metalloproteinase 1; Nicotinic Aci | 2009 |
Questionable techniques for evaluating photodamage.
Topics: Administration, Topical; Humans; Nicotinic Acids; Ointments; Sensitivity and Specificity; Severity o | 2002 |
Questions & answers. Of all the treatments that promise to improve the appearance of aging skin, which ones have been medically proven to actually work?
Topics: Cryotherapy; Dermatologic Agents; Humans; Keratolytic Agents; Laser Therapy; Nicotinic Acids; Skin A | 2004 |