taurocholic acid has been researched along with Acute Liver Injury, Drug-Induced in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.09) | 18.7374 |
| 1990's | 1 (3.03) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 23 (69.70) | 24.3611 |
| 2020's | 5 (15.15) | 2.80 |
| Authors | Studies |
|---|---|
| Braeuning, A; Enge, AM; Geyer, J; Gottschalk, C; Hammer, H; Hessel-Pras, S; Kaltner, F; Kin, A; Kirstgen, M; Pötz, O; These, A | 1 |
| Brouwer, KLR; Fallon, JK; Fu, D; Ho, H; Honkakoski, P; Klein, A; Saran, C | 1 |
| Aleo, MD; Barton, HA; Di, L; Generaux, G; Howell, BA; Lakhani, VV; Nadanaciva, S; Qiu, L; Riccardi, K; Shoda, LKM; Siler, SQ; Watkins, PB; Yang, Y | 1 |
| Beaudoin, JJ; Bezençon, J; Brouwer, KLR; Fallon, JK; Sjöstedt, N | 1 |
| Jia, J; Kong, Y; Li, M; Liu, J; Liu, L; Ma, H; Ou, X; Saxena, R; Shan, S; Tian, Q; Wang, L; Wang, Y; Wee, A; Yang, R; You, H; Zhao, X | 1 |
| Baudy, A; Chen, Q; Evers, R; Hafey, MJ; Houle, R; Knemeyer, I; Monroe, J; Shang, J; Sistare, FD; Tanis, KQ | 1 |
| Fukami, T; Golla, S; Gonzalez, FJ; Jiang, C; Krausz, KW; Masuo, Y; Polunas, MA; Takahashi, S; Tanaka, N; Weig, BC; Xie, C | 1 |
| Chen, JQ; Guo, Q; Liu, BM; Qiu, HC; Xu, FG; Zhang, QQ; Zhang, W; Zhang, ZJ | 1 |
| Ali, I; Beaudoin, JJ; Bezençon, J; Brouwer, KLR; Malinen, MM | 1 |
| Tao, YY; Xu, Y; Zhong, PP | 1 |
| Cai, W; Lu, Y; Wang, Y; Xiao, Y; Yan, W; Zhou, K | 1 |
| Ali, I; Brouwer, KLR; Khalid, S; Stieger, B | 1 |
| Aubrecht, J; Colangelo, JL; Houle, C; Luo, L; Schomaker, S | 1 |
| Anderson, D; Chiang, PC; Daniels, JS; Davis Ii, JW; Feng, B; Lai, Y; McKenzie, JW; Mireles, R; Mourey, R; South, S; Stevens, J; Walker, D; Whiteley, LO | 1 |
| Cai, BC; Cai, H; Li, H; Liu, X; Wu, L; Zheng, SZ | 1 |
| Brouwer, KL; Köck, K; Pfeifer, ND; Yang, K | 1 |
| Cai, L; He, K; Liu, H; Shi, Q; Woolf, TF | 1 |
| Brock, WJ; Brouwer, KL; Brouwer, KR; Freeman, KM; Lu, Y; Pan, M; Slizgi, JR; St Claire, RL | 1 |
| Locher, KP; Mahdi, ZM; Stieger, B; Synal-Hermanns, U; Yoker, A | 1 |
| Dong, LC; Dong, X; Fan, YX; Jiang, LL; Li, HJ; Li, P; Ma, J; Xu, XJ; Zhao, DS | 1 |
| Ansede, JH; Brouwer, KR; Perry, CH; Smith, WR; St Claire, RL | 1 |
| Bridges, AS; Brouwer, KL; Corbett, AH; Kashuba, AD; McRae, M; Rezk, NL; Tien, HC | 1 |
| Jemnitz, K; Vereczkey, L; Veres, Z | 1 |
| Fujiwake, H; Ikegawa, M; Kanzaki, A; Nakanishi, T; Sato, TA; Shimada, T; Toyama, A; Yamauchi, S | 1 |
| Brouwer, KL; Marion, TL; Perry, CH; St Claire, RL; Yue, W | 1 |
| Chen, CC; Hu, ZB; Ji, LL; Wang, JM; Wang, ZT; Xu, Y; Yang, L | 1 |
| Ikebuchi, Y; Ito, K; Shimizu, H; Suzuki, H; Takada, T; Yamanashi, Y; Yoshikado, T | 1 |
| Ito, K; Santa, T; Suzuki, H; Takada, T; Tan, JK; Yamamoto, H; Yoshikado, T | 1 |
| Beuers, U; Kerb, R; Kullak-Ublick, GA; Lang, C; Lang, T; Meier, PJ; Meier, Y; Pauli-Magnus, C; Stieger, B | 1 |
| Caple, IW; Heath, TJ | 1 |
| Boyer, JL; Layden, TJ | 1 |
| Berndt, WO; Cooke, WJ; Mudge, GH | 1 |
| Berenson, MM; Bjorkman, DJ; Gunther, C; Samowitz, WS | 1 |
1 trial(s) available for taurocholic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.
Topics: Administration, Oral; Adolescent; Adult; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 11; Chemical and Drug Induced Liver Injury; Computer Simulation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epilepsy; Healthy Volunteers; HEK293 Cells; Hepatocytes; Humans; Inhibitory Concentration 50; Liver; Male; Middle Aged; Mitochondria; Models, Biological; Quinazolines; Rats; Species Specificity; Taurocholic Acid; Young Adult | 2019 |
32 other study(ies) available for taurocholic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Organic Cation Transporter I and Na
Topics: Cations; Chemical and Drug Induced Liver Injury; Hepatocytes; Humans; Peptides; Pyrrolizidine Alkaloids; Taurocholic Acid | 2022 |
A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity.
Topics: Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestasis; Hepatocytes; Humans; Liver; Membrane Transport Proteins; Organic Anion Transporters, Sodium-Dependent; Symporters; Taurocholic Acid | 2022 |
Role of Organic Solute Transporter Alpha/Beta in Hepatotoxic Bile Acid Transport and Drug Interactions.
Topics: Animals; Bile Acids and Salts; Biological Transport; Chemical and Drug Induced Liver Injury; Chenodeoxycholic Acid; Cholestasis; Drug Interactions; Hepatocytes; Humans; Ion Transport; Kinetics; Liver; Membrane Transport Proteins; Pharmaceutical Preparations; Proteomics; Taurocholic Acid | 2020 |
A High Serum Level of Taurocholic Acid Is Correlated With the Severity and Resolution of Drug-induced Liver Injury.
Topics: Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Prospective Studies; Taurocholic Acid | 2021 |
A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; Chemical and Drug Induced Liver Injury; Coculture Techniques; Drug Discovery; Drug Evaluation, Preclinical; Hepatocytes; Humans; Inhibitory Concentration 50; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Taurocholic Acid | 2020 |
Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Taurocholic Acid | 2017 |
Liver metabolomics study reveals protective function of Phyllanthus urinaria against CCl
Topics: Amino Acids; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Humans; Liver; Male; Metabolomics; Phyllanthus; Rats; Rats, Sprague-Dawley; Taurocholic Acid | 2017 |
Organic solute transporter OSTα/β is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury.
Topics: Bile Acids and Salts; Biological Transport; Biomarkers; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Glycochenodeoxycholic Acid; Hepatocytes; Humans; Liver; Liver Cirrhosis, Biliary; Male; Membrane Transport Proteins; Middle Aged; Non-alcoholic Fatty Liver Disease; Taurocholic Acid | 2018 |
Metabolic profiling of endogenous bile acids: a novel method to assess hepatoprotective effect of Tanreqing capsule on carbon-tetrachloride-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Drugs, Chinese Herbal; Female; Liver; Male; Mass Spectrometry; Metabolome; Metabolomics; Rats; Rats, Wistar; Taurocholic Acid; Taurodeoxycholic Acid | 2018 |
Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling.
Topics: Animals; Bacterial Proteins; Bacteroides; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cholestasis; Cytochrome P-450 Enzyme System; Eubacterium; Female; Fibroblast Growth Factors; Gastrointestinal Microbiome; Gentamicins; Gram-Positive Bacteria; Humans; Infant; Intestines; Liver; Male; Mice; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Taurocholic Acid; Vancomycin | 2018 |
Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Baculoviridae; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis; Dipyridamole; Erythromycin; Glycocholic Acid; Ketoconazole; Kinetics; Membrane Transport Proteins; Polymorphism, Single Nucleotide; Sf9 Cells; Signal Transduction; Spodoptera; Taurocholic Acid; Transport Vesicles | 2019 |
Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents.
Topics: Animals; Bile Acids and Salts; Bile Ducts; Biomarkers; Chemical and Drug Induced Liver Injury; Cholic Acid; Chromatography, Liquid; Clinical Enzyme Tests; Disease Models, Animal; Enzymes; Glycocholic Acid; Hyperplasia; Liver; Male; Mice; Necrosis; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tandem Mass Spectrometry; Taurocholic Acid | 2014 |
Inhibition of hepatobiliary transporters by a novel kinase inhibitor contributes to hepatotoxicity in beagle dogs.
Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Carrier Proteins; Cell Line; Chemical and Drug Induced Liver Injury; Dogs; Drug Resistance, Multiple; Fluoresceins; Fluorescent Dyes; Liver; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Protein Kinase Inhibitors; Taurocholic Acid | 2013 |
Da-Huang-Fu-Zi-Tang attenuates liver injury in rats with severe acute pancreatitis.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Interleukin-6; Janus Kinase 2; Kupffer Cells; Liver; Male; Pancreatitis; Phytotherapy; Protective Agents; Rats; Rats, Sprague-Dawley; RNA, Messenger; STAT3 Transcription Factor; Taurocholic Acid; Tumor Necrosis Factor-alpha | 2013 |
Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury.
Topics: Adult; Animals; Bile Ducts; Biological Transport; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromans; Dehydroepiandrosterone; Female; Hepatocytes; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Rats; Species Specificity; Sulfuric Acid Esters; Taurocholic Acid; Thiazolidinediones; Troglitazone | 2015 |
Inhibition of MDR3 Activity in Human Hepatocytes by Drugs Associated with Liver Injury.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Deuterium; Hepatocytes; Humans; Itraconazole; Phosphatidylcholines; Tandem Mass Spectrometry; Taurocholic Acid; Verapamil | 2015 |
Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Carrier Proteins; Chemical and Drug Induced Liver Injury; CHO Cells; Cricetulus; Hepatocytes; Humans; Membrane Glycoproteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Polycystic Kidney, Autosomal Dominant; Taurocholic Acid; Tolvaptan | 2016 |
Role of Multidrug Resistance Protein 3 in Antifungal-Induced Cholestasis.
Topics: Animals; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azoles; Bile Acids and Salts; Biological Transport; Blotting, Western; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis; Humans; LLC-PK1 Cells; Phospholipids; Reproducibility of Results; Swine; Taurocholic Acid | 2016 |
Identification of urine tauro-β-muricholic acid as a promising biomarker in Polygoni Multiflori Radix-induced hepatotoxicity by targeted metabolomics of bile acids.
Topics: Animals; Bile Acids and Salts; Biomarkers; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fallopia multiflora; Male; Metabolomics; Rats; Rats, Sprague-Dawley; Taurocholic Acid | 2017 |
An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes.
Topics: Algorithms; Animals; Bile; Bile Acids and Salts; Biological Transport; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Chromatography, High Pressure Liquid; Collagen; Culture Techniques; Dose-Response Relationship, Drug; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Hepatocytes; Laminin; Male; Proteoglycans; Rats; Rats, Wistar; Tandem Mass Spectrometry; Taurocholic Acid; Toxicity Tests | 2010 |
Plasma bile acid concentrations in patients with human immunodeficiency virus infection receiving protease inhibitor therapy: possible implications for hepatotoxicity.
Topics: Adult; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chenodeoxycholic Acid; Chromatography, High Pressure Liquid; Early Diagnosis; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lithocholic Acid; Liver; Male; Middle Aged; Retrospective Studies; Severity of Illness Index; Tandem Mass Spectrometry; Taurocholic Acid; Time Factors | 2010 |
Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Chromans; Humans; Hypoglycemic Agents; Male; Organic Anion Transporters, Sodium-Dependent; Rats; Rats, Wistar; Species Specificity; Symporters; Taurocholic Acid; Thiazolidinediones; Troglitazone | 2010 |
Potential implications for monitoring serum bile acid profiles in circulation with serum proteome for carbon tetrachloride-induced liver injury/regeneration model in mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Biomarkers; Blood Proteins; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electrophoresis, Gel, Two-Dimensional; Glycine; Histocytochemistry; Liver Regeneration; Male; Mice; Mice, Inbred ICR; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Taurine; Taurocholic Acid | 2010 |
Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.
Topics: Animals; ATP-Binding Cassette Transporters; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chenodeoxycholic Acid; Chromans; Chromatography, High Pressure Liquid; Hepatocytes; Male; PPAR gamma; Propionates; Quinolines; Rats; Rats, Wistar; Tandem Mass Spectrometry; Taurocholic Acid; Thiazolidinediones; Troglitazone | 2011 |
[Evaluation on hepatotoxicity caused by Dioscorea bulbifera based on analysis of bile acids].
Topics: Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholic Acid; Chromatography, High Pressure Liquid; Dioscorea; Drugs, Chinese Herbal; Heterocyclic Compounds, 4 or More Rings; Least-Squares Analysis; Male; Mice; Mice, Inbred ICR; Plants, Medicinal; Principal Component Analysis; Rhizome; Tandem Mass Spectrometry; Taurochenodeoxycholic Acid; Taurocholic Acid; Taurodeoxycholic Acid | 2011 |
Ursodeoxycholic acid stimulates the formation of the bile canalicular network.
Topics: Animals; Biliary Tract; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Hepatocytes; Male; MAP Kinase Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Rats; Rats, Wistar; Taurocholic Acid; Ursodeoxycholic Acid | 2012 |
Ticlopidine, a cholestatic liver injury-inducible drug, causes dysfunction of bile formation via diminished biliary secretion of phospholipids: involvement of biliary-excreted glutathione-conjugated ticlopidine metabolites.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Biliary Tract; Biological Transport; Chemical and Drug Induced Liver Injury; Cholestasis; Cytochrome P-450 Enzyme System; Glutathione; Liver; Male; Membrane Transport Proteins; Phospholipids; Rats; Rats, Sprague-Dawley; Taurocholic Acid; Ticlopidine | 2013 |
Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Genetic Predisposition to Disease; Humans; Liver Diseases; Male; Middle Aged; Molecular Sequence Data; Mutation; Polymorphism, Genetic; Protein Structure, Secondary; Taurocholic Acid; White People | 2007 |
Effect of chronic liver damage caused by ingestion of Heliotropium europaeum on bile formation in sheep.
Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Female; Liver; Male; Pyrrolizidine Alkaloids; Secretin; Sheep; Taurocholic Acid | 1979 |
Taurolithocholate-induced cholestasis: taurocholate but not dehydrocholate, reverses cholestasis and bile canalicular membrane injury.
Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Cholestasis; Cholic Acids; Dehydrocholic Acid; Disease Models, Animal; Erythritol; Inulin; Lithocholic Acid; Liver; Liver Function Tests; Male; Microscopy, Electron, Scanning; Rats; Secretory Rate; Taurocholic Acid | 1977 |
Effect of biliary stasis and hepatotoxins on the excretion of iopanoate in the rat.
Topics: Animals; Bile Ducts; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholestasis; Glomerular Filtration Rate; Glucuronates; Iodine Radioisotopes; Iopanoic Acid; Kidney; Kinetics; Lithocholic Acid; Liver; Male; Naphthalenes; Proadifen; Rats; Taurocholic Acid; Thiocyanates | 1975 |
Formation of biliary thrombi in protoporphyrin-induced cholestasis in perfused rat liver.
Topics: Animals; Bile; Bile Acids and Salts; Biliary Tract Diseases; Chemical and Drug Induced Liver Injury; Chenodeoxycholic Acid; Cholestasis; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Liver Diseases; Microscopy, Electron; Perfusion; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains; Taurocholic Acid; Ursodeoxycholic Acid | 1990 |