taurochenodeoxycholic-acid has been researched along with Silicosis* in 1 studies
1 other study(ies) available for taurochenodeoxycholic-acid and Silicosis
| Article | Year |
|---|---|
Tauroursodeoxycholic acid (TUDCA) disparate pharmacological effects to lung tissue-resident memory T cells contribute to alleviated silicosis.
Exposure to crystalline silica (CS) results in a persistent pulmonary inflammatory response, which results in abnormal tissue repair and excessive matrix deposition. Due to vague pathogenesis, there is virtually no practical therapeutic approach. Here we showed the pharmacological effects of TUDCA on CS-induced pulmonary inflammation and fibrosis. It also helped a faster recovery of CS-impaired pulmonary function. Mechanistically, TUDCA suppressed interferon (IFN)-γ and interleukin (IL)-17A productions by pulmonary helper T (Th) cells. We demonstrated that CS-boosted cytokine-producing Th cells were effector memory (T Topics: CD8-Positive T-Lymphocytes; Fibrosis; Humans; Immunologic Memory; Lung; Memory T Cells; Silicon Dioxide; Silicosis; Taurochenodeoxycholic Acid | 2022 |