taurochenodeoxycholic-acid has been researched along with Ileitis* in 1 studies
1 other study(ies) available for taurochenodeoxycholic-acid and Ileitis
| Article | Year |
|---|---|
Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn's disease-like ileitis.
Bile acids regulate the expression of intestinal bile acid transporters and are natural ligands for nuclear receptors controlling inflammation. Accumulating evidence suggests that signaling through these receptors is impaired in inflammatory bowel disease. We investigated whether tauroursodeoxycholic acid (TUDCA), a secondary bile acid with cytoprotective properties, regulates ileal nuclear receptor and bile acid transporter expression and assessed its therapeutic potential in an experimental model of Crohn's disease (CD). Gene expression of the nuclear receptors farnesoid X receptor, pregnane X receptor and vitamin D receptor and the bile acid transporters apical sodium-dependent bile acid transporter and organic solute transporter α and β was analyzed in Caco-2 cell monolayers exposed to tumor necrosis factor (TNF)α, in ileal tissue of TNF Topics: Adult; Animals; Bile Acids and Salts; Caco-2 Cells; Carrier Proteins; Crohn Disease; Disease Models, Animal; Down-Regulation; Female; Homeostasis; Humans; Ileitis; Ileum; Male; Membrane Glycoproteins; Mice; Mice, Transgenic; Receptors, Cytoplasmic and Nuclear; Taurochenodeoxycholic Acid; Young Adult | 2017 |